Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K/AKT/mTOR Signaling Axis to Attenuate Steroid-Induced Osteoporosis

Steroid-induced osteoporosis (SIOP) is a form of secondary osteoporosis, but its specific mechanism remains unclear. Glucocorticoid (GC-)-induced death of osteoblasts and bone marrow mesenchymal stem cells (BMSCs) is an important factor in SIOP. Ferroptosis is an iron-dependent type of programmed ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.8223737-22
Hauptverfasser:	Li, Meng, Yang, Ning, Hao, Li, Zhou, Wei, Li, Lei, Liu, Lei, Yang, Fang, Xu, Lei, Yao, Gang, Zhu, Chen, Xu, Wei, Fang, Shiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Bone marrow Ferroptosis Ferroptosis - drug effects Lasers Medical research Melatonin Melatonin - pharmacology Mesenchymal Stem Cells - drug effects Metabolism Mitochondrial DNA Morphology Osteoporosis Osteoporosis - chemically induced Oxidative stress Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Rats Rats, Sprague-Dawley Signal Transduction Stem cells Steroids Steroids - adverse effects TOR Serine-Threonine Kinases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!