Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity
Background. Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in me...
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| Veröffentlicht in: | Journal of personalized medicine 2022-07, Vol.12 (8), p.1248 |
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| creator | Striukova, Evgeniia Vital’evna Shramko, Victoriya Sergeevna Kashtanova, Elena Vladimirovna Polonskaya, Yana Vladimirovna Stakhneva, Ekaterina Mikhailovna Kurguzov, Alexey Vitalievich Chernyavsky, Alexander Mikhailovich Ragino, Yulia Igorevna |
| description | Background. Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. Materials and methods. The study involved 82 men aged 40–77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m2. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. Results. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. Conclusions. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α. |
| doi_str_mv | 10.3390/jpm12081248 |
| format | Article |
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Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. Materials and methods. The study involved 82 men aged 40–77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m2. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. Results. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. Conclusions. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm12081248</identifier><identifier>PMID: 36013196</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Body fat ; Body mass index ; Chronic illnesses ; Coronary artery ; Dyslipidemia ; Inflammation ; Insulin ; Interleukin 6 ; Obesity ; Plaques ; Precision medicine ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Journal of personalized medicine, 2022-07, Vol.12 (8), p.1248</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-83946a0fb4dd99566dc296af0865d99ba6c491f6e2ae29b83872f61b6721e0373</citedby><cites>FETCH-LOGICAL-c386t-83946a0fb4dd99566dc296af0865d99ba6c491f6e2ae29b83872f61b6721e0373</cites><orcidid>0000-0003-0484-6540 ; 0000-0003-2268-4186 ; 0000-0002-0436-2549 ; 0000-0002-4936-8362 ; 0000-0002-3538-0280 ; 0000-0002-0540-3357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409903/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409903/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Striukova, Evgeniia Vital’evna</creatorcontrib><creatorcontrib>Shramko, Victoriya Sergeevna</creatorcontrib><creatorcontrib>Kashtanova, Elena Vladimirovna</creatorcontrib><creatorcontrib>Polonskaya, Yana Vladimirovna</creatorcontrib><creatorcontrib>Stakhneva, Ekaterina Mikhailovna</creatorcontrib><creatorcontrib>Kurguzov, Alexey Vitalievich</creatorcontrib><creatorcontrib>Chernyavsky, Alexander Mikhailovich</creatorcontrib><creatorcontrib>Ragino, Yulia Igorevna</creatorcontrib><title>Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity</title><title>Journal of personalized medicine</title><description>Background. Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. Materials and methods. The study involved 82 men aged 40–77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m2. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. Results. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. Conclusions. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Chronic illnesses</subject><subject>Coronary artery</subject><subject>Dyslipidemia</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Interleukin 6</subject><subject>Obesity</subject><subject>Plaques</subject><subject>Precision medicine</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1LAzEQhoMoKtqTfyDgRZDqJNnNbi5CLX5BpRe9CSG7m23T7iY12VX6701tEXUOM8PMw8t8IHRG4IoxAdeLVUso5IQm-R46ppClwyShfP9XfoQGISwgWp5SyuEQHTEOhBHBj9HbqDIrtzRW44n-0E3AxuJnbfGn6eZ47Lyzyq_xqJtr70LZbLwJ2FkcK_hWlcuZd72tsKvxqKhca6xq8LTQwXTrU3RQqybowS6eoNf7u5fx43AyfXgajybDkuW8G-ZMJFxBXSRVJUTKeVVSwVUNOU9joVC8TASpuaZKU1HkLM9ozUnBM0o0sIydoJut7qovWl2V2nZeNXLlTRuHl04Z-bdjzVzO3IcUCQgBLApc7AS8e-916GRrQqmbRlnt-iBpBhmHjAJE9PwfunC9j0t_U5wmEUojdbmlyniv4HX9MwwBuXmc_PU49gXXOYmW</recordid><startdate>20220729</startdate><enddate>20220729</enddate><creator>Striukova, Evgeniia Vital’evna</creator><creator>Shramko, Victoriya Sergeevna</creator><creator>Kashtanova, Elena Vladimirovna</creator><creator>Polonskaya, Yana Vladimirovna</creator><creator>Stakhneva, Ekaterina Mikhailovna</creator><creator>Kurguzov, Alexey Vitalievich</creator><creator>Chernyavsky, Alexander Mikhailovich</creator><creator>Ragino, Yulia Igorevna</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0484-6540</orcidid><orcidid>https://orcid.org/0000-0003-2268-4186</orcidid><orcidid>https://orcid.org/0000-0002-0436-2549</orcidid><orcidid>https://orcid.org/0000-0002-4936-8362</orcidid><orcidid>https://orcid.org/0000-0002-3538-0280</orcidid><orcidid>https://orcid.org/0000-0002-0540-3357</orcidid></search><sort><creationdate>20220729</creationdate><title>Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity</title><author>Striukova, Evgeniia Vital’evna ; Shramko, Victoriya Sergeevna ; Kashtanova, Elena Vladimirovna ; Polonskaya, Yana Vladimirovna ; Stakhneva, Ekaterina Mikhailovna ; Kurguzov, Alexey Vitalievich ; Chernyavsky, Alexander Mikhailovich ; Ragino, Yulia Igorevna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-83946a0fb4dd99566dc296af0865d99ba6c491f6e2ae29b83872f61b6721e0373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Chronic illnesses</topic><topic>Coronary artery</topic><topic>Dyslipidemia</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Interleukin 6</topic><topic>Obesity</topic><topic>Plaques</topic><topic>Precision medicine</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Striukova, Evgeniia Vital’evna</creatorcontrib><creatorcontrib>Shramko, Victoriya Sergeevna</creatorcontrib><creatorcontrib>Kashtanova, Elena Vladimirovna</creatorcontrib><creatorcontrib>Polonskaya, Yana Vladimirovna</creatorcontrib><creatorcontrib>Stakhneva, Ekaterina Mikhailovna</creatorcontrib><creatorcontrib>Kurguzov, Alexey Vitalievich</creatorcontrib><creatorcontrib>Chernyavsky, Alexander Mikhailovich</creatorcontrib><creatorcontrib>Ragino, Yulia Igorevna</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Striukova, Evgeniia Vital’evna</au><au>Shramko, Victoriya Sergeevna</au><au>Kashtanova, Elena Vladimirovna</au><au>Polonskaya, Yana Vladimirovna</au><au>Stakhneva, Ekaterina Mikhailovna</au><au>Kurguzov, Alexey Vitalievich</au><au>Chernyavsky, Alexander Mikhailovich</au><au>Ragino, Yulia Igorevna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity</atitle><jtitle>Journal of personalized medicine</jtitle><date>2022-07-29</date><risdate>2022</risdate><volume>12</volume><issue>8</issue><spage>1248</spage><pages>1248-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Background. Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. The goal of research. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. Materials and methods. The study involved 82 men aged 40–77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m2. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. Results. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. Conclusions. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36013196</pmid><doi>10.3390/jpm12081248</doi><orcidid>https://orcid.org/0000-0003-0484-6540</orcidid><orcidid>https://orcid.org/0000-0003-2268-4186</orcidid><orcidid>https://orcid.org/0000-0002-0436-2549</orcidid><orcidid>https://orcid.org/0000-0002-4936-8362</orcidid><orcidid>https://orcid.org/0000-0002-3538-0280</orcidid><orcidid>https://orcid.org/0000-0002-0540-3357</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arteriosclerosis Atherosclerosis Body fat Body mass index Chronic illnesses Coronary artery Dyslipidemia Inflammation Insulin Interleukin 6 Obesity Plaques Precision medicine Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Adipokine Levels in Men with Coronary Atherosclerosis on the Background of Abdominal Obesity |
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