Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade
In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a ret...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2022-08, Vol.11 (16), p.4792 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 16 |
| container_start_page | 4792 |
| container_title | Journal of clinical medicine |
| container_volume | 11 |
| creator | Bedin, Alice Carbonnel, Marie Snanoudj, Renaud Roux, Antoine Vanlieferinghen, Sarah Marchiori, Claire Hertig, Alexandre Racowsky, Catherine Ayoubi, Jean-Marc |
| description | In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a retrospective study in two French centers for kidney and lung transplantations to evaluate the rate and outcomes of pregnancies, contraception and gynecological monitoring for women under 40 years old who underwent solid organ transplantation. Among 210 women, progestin was the most widely used contraceptive method. Of the 210 women, 24 (11.4%) conceived 33 pregnancies of which 25 (75.8%) were planned with an immunosuppressant therapy switch. Of the 33 pregnancies, 7 miscarried (21.2%) and 21 (63.7%) resulted in a live birth with a high rate of pre-eclampsia (50%). No graft rejections were observed during pregnancies. Among the deliveries, 19 were premature (90.5%, mostly due to induced delivery) and the C-section rate was high (52.4%). No particular pathology was identified among newborns. We conclude that pregnancies following solid organ transplantation are feasible, and while they are at an increased risk of pre-eclampsia and prematurity, they should still be permitted with close surveillance by a multidisciplinary care team. |
| doi_str_mv | 10.3390/jcm11164792 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9409658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2707607371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-2b529bdb52eb8c47a451ab34922c8b324d909c8fb422378edac82dc29bd3d59d3</originalsourceid><addsrcrecordid>eNpdkV1rFTEQhoMottRe-QcC3iiymq_dJF4IpfYLDlSwvQ6zSfY0h5xkTfZU--_d5ZRSOxczQ-aZd8IMQu8p-cK5Jl83dksp7YTU7BU6ZETKhnDFXz_LD9BxrRsym1KCUfkWHfCOUE44OUTws_h1gmSDrxiSwxcPydsc8zpYiPg8x5j_NLcjhmHyBf_KMTh8XdaQ8E2BVMcIaYIp5PQNn_0dfQk-WY_zgAH_8Bacf4feDBCrP36MR-j2_Ozm9LJZXV9cnZ6sGstbMjWsb5nu3ex9r6yQIFoKPReaMat6zoTTRFs19IIxLpV3YBVzdunhrtWOH6Hve91x12-9sz5NBaIZS9hCeTAZgvm_ksKdWed7owXRXatmgU97gbsXbZcnK7O8ESEUo5rf05n9-Dis5N87XyezDdX6OG_D5101TBLZEcnlgn54gW7yrqR5FQvVMSqY1jP1eU_Zkmstfnj6ASVmubR5dmn-D2_bmYk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2706214299</pqid></control><display><type>article</type><title>Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Bedin, Alice ; Carbonnel, Marie ; Snanoudj, Renaud ; Roux, Antoine ; Vanlieferinghen, Sarah ; Marchiori, Claire ; Hertig, Alexandre ; Racowsky, Catherine ; Ayoubi, Jean-Marc</creator><creatorcontrib>Bedin, Alice ; Carbonnel, Marie ; Snanoudj, Renaud ; Roux, Antoine ; Vanlieferinghen, Sarah ; Marchiori, Claire ; Hertig, Alexandre ; Racowsky, Catherine ; Ayoubi, Jean-Marc</creatorcontrib><description>In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a retrospective study in two French centers for kidney and lung transplantations to evaluate the rate and outcomes of pregnancies, contraception and gynecological monitoring for women under 40 years old who underwent solid organ transplantation. Among 210 women, progestin was the most widely used contraceptive method. Of the 210 women, 24 (11.4%) conceived 33 pregnancies of which 25 (75.8%) were planned with an immunosuppressant therapy switch. Of the 33 pregnancies, 7 miscarried (21.2%) and 21 (63.7%) resulted in a live birth with a high rate of pre-eclampsia (50%). No graft rejections were observed during pregnancies. Among the deliveries, 19 were premature (90.5%, mostly due to induced delivery) and the C-section rate was high (52.4%). No particular pathology was identified among newborns. We conclude that pregnancies following solid organ transplantation are feasible, and while they are at an increased risk of pre-eclampsia and prematurity, they should still be permitted with close surveillance by a multidisciplinary care team.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11164792</identifier><identifier>PMID: 36013030</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Birth control ; Blood pressure ; Clinical medicine ; Creatinine ; Cystic fibrosis ; Diabetes ; Disease ; Gynecology ; Hospitals ; Humanities and Social Sciences ; Hypertension ; Kidney transplants ; Life Sciences ; Lung transplants ; Nephrology ; Patients ; Preeclampsia ; Pregnancy ; Quality of life ; Thoracic surgery ; Womens health</subject><ispartof>Journal of clinical medicine, 2022-08, Vol.11 (16), p.4792</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-2b529bdb52eb8c47a451ab34922c8b324d909c8fb422378edac82dc29bd3d59d3</citedby><cites>FETCH-LOGICAL-c350t-2b529bdb52eb8c47a451ab34922c8b324d909c8fb422378edac82dc29bd3d59d3</cites><orcidid>0000-0001-9935-1203 ; 0000-0002-2903-3303</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409658/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409658/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04482193$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bedin, Alice</creatorcontrib><creatorcontrib>Carbonnel, Marie</creatorcontrib><creatorcontrib>Snanoudj, Renaud</creatorcontrib><creatorcontrib>Roux, Antoine</creatorcontrib><creatorcontrib>Vanlieferinghen, Sarah</creatorcontrib><creatorcontrib>Marchiori, Claire</creatorcontrib><creatorcontrib>Hertig, Alexandre</creatorcontrib><creatorcontrib>Racowsky, Catherine</creatorcontrib><creatorcontrib>Ayoubi, Jean-Marc</creatorcontrib><title>Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade</title><title>Journal of clinical medicine</title><description>In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a retrospective study in two French centers for kidney and lung transplantations to evaluate the rate and outcomes of pregnancies, contraception and gynecological monitoring for women under 40 years old who underwent solid organ transplantation. Among 210 women, progestin was the most widely used contraceptive method. Of the 210 women, 24 (11.4%) conceived 33 pregnancies of which 25 (75.8%) were planned with an immunosuppressant therapy switch. Of the 33 pregnancies, 7 miscarried (21.2%) and 21 (63.7%) resulted in a live birth with a high rate of pre-eclampsia (50%). No graft rejections were observed during pregnancies. Among the deliveries, 19 were premature (90.5%, mostly due to induced delivery) and the C-section rate was high (52.4%). No particular pathology was identified among newborns. We conclude that pregnancies following solid organ transplantation are feasible, and while they are at an increased risk of pre-eclampsia and prematurity, they should still be permitted with close surveillance by a multidisciplinary care team.</description><subject>Birth control</subject><subject>Blood pressure</subject><subject>Clinical medicine</subject><subject>Creatinine</subject><subject>Cystic fibrosis</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Humanities and Social Sciences</subject><subject>Hypertension</subject><subject>Kidney transplants</subject><subject>Life Sciences</subject><subject>Lung transplants</subject><subject>Nephrology</subject><subject>Patients</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Quality of life</subject><subject>Thoracic surgery</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkV1rFTEQhoMottRe-QcC3iiymq_dJF4IpfYLDlSwvQ6zSfY0h5xkTfZU--_d5ZRSOxczQ-aZd8IMQu8p-cK5Jl83dksp7YTU7BU6ZETKhnDFXz_LD9BxrRsym1KCUfkWHfCOUE44OUTws_h1gmSDrxiSwxcPydsc8zpYiPg8x5j_NLcjhmHyBf_KMTh8XdaQ8E2BVMcIaYIp5PQNn_0dfQk-WY_zgAH_8Bacf4feDBCrP36MR-j2_Ozm9LJZXV9cnZ6sGstbMjWsb5nu3ex9r6yQIFoKPReaMat6zoTTRFs19IIxLpV3YBVzdunhrtWOH6Hve91x12-9sz5NBaIZS9hCeTAZgvm_ksKdWed7owXRXatmgU97gbsXbZcnK7O8ESEUo5rf05n9-Dis5N87XyezDdX6OG_D5101TBLZEcnlgn54gW7yrqR5FQvVMSqY1jP1eU_Zkmstfnj6ASVmubR5dmn-D2_bmYk</recordid><startdate>20220816</startdate><enddate>20220816</enddate><creator>Bedin, Alice</creator><creator>Carbonnel, Marie</creator><creator>Snanoudj, Renaud</creator><creator>Roux, Antoine</creator><creator>Vanlieferinghen, Sarah</creator><creator>Marchiori, Claire</creator><creator>Hertig, Alexandre</creator><creator>Racowsky, Catherine</creator><creator>Ayoubi, Jean-Marc</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>BXJBU</scope><scope>IHQJB</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9935-1203</orcidid><orcidid>https://orcid.org/0000-0002-2903-3303</orcidid></search><sort><creationdate>20220816</creationdate><title>Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade</title><author>Bedin, Alice ; Carbonnel, Marie ; Snanoudj, Renaud ; Roux, Antoine ; Vanlieferinghen, Sarah ; Marchiori, Claire ; Hertig, Alexandre ; Racowsky, Catherine ; Ayoubi, Jean-Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-2b529bdb52eb8c47a451ab34922c8b324d909c8fb422378edac82dc29bd3d59d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Birth control</topic><topic>Blood pressure</topic><topic>Clinical medicine</topic><topic>Creatinine</topic><topic>Cystic fibrosis</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Gynecology</topic><topic>Hospitals</topic><topic>Humanities and Social Sciences</topic><topic>Hypertension</topic><topic>Kidney transplants</topic><topic>Life Sciences</topic><topic>Lung transplants</topic><topic>Nephrology</topic><topic>Patients</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Quality of life</topic><topic>Thoracic surgery</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bedin, Alice</creatorcontrib><creatorcontrib>Carbonnel, Marie</creatorcontrib><creatorcontrib>Snanoudj, Renaud</creatorcontrib><creatorcontrib>Roux, Antoine</creatorcontrib><creatorcontrib>Vanlieferinghen, Sarah</creatorcontrib><creatorcontrib>Marchiori, Claire</creatorcontrib><creatorcontrib>Hertig, Alexandre</creatorcontrib><creatorcontrib>Racowsky, Catherine</creatorcontrib><creatorcontrib>Ayoubi, Jean-Marc</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>HAL-SHS: Archive ouverte en Sciences de l'Homme et de la Société</collection><collection>HAL-SHS: Archive ouverte en Sciences de l'Homme et de la Société (Open Access)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bedin, Alice</au><au>Carbonnel, Marie</au><au>Snanoudj, Renaud</au><au>Roux, Antoine</au><au>Vanlieferinghen, Sarah</au><au>Marchiori, Claire</au><au>Hertig, Alexandre</au><au>Racowsky, Catherine</au><au>Ayoubi, Jean-Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade</atitle><jtitle>Journal of clinical medicine</jtitle><date>2022-08-16</date><risdate>2022</risdate><volume>11</volume><issue>16</issue><spage>4792</spage><pages>4792-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a retrospective study in two French centers for kidney and lung transplantations to evaluate the rate and outcomes of pregnancies, contraception and gynecological monitoring for women under 40 years old who underwent solid organ transplantation. Among 210 women, progestin was the most widely used contraceptive method. Of the 210 women, 24 (11.4%) conceived 33 pregnancies of which 25 (75.8%) were planned with an immunosuppressant therapy switch. Of the 33 pregnancies, 7 miscarried (21.2%) and 21 (63.7%) resulted in a live birth with a high rate of pre-eclampsia (50%). No graft rejections were observed during pregnancies. Among the deliveries, 19 were premature (90.5%, mostly due to induced delivery) and the C-section rate was high (52.4%). No particular pathology was identified among newborns. We conclude that pregnancies following solid organ transplantation are feasible, and while they are at an increased risk of pre-eclampsia and prematurity, they should still be permitted with close surveillance by a multidisciplinary care team.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36013030</pmid><doi>10.3390/jcm11164792</doi><orcidid>https://orcid.org/0000-0001-9935-1203</orcidid><orcidid>https://orcid.org/0000-0002-2903-3303</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2022-08, Vol.11 (16), p.4792 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9409658 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Birth control Blood pressure Clinical medicine Creatinine Cystic fibrosis Diabetes Disease Gynecology Hospitals Humanities and Social Sciences Hypertension Kidney transplants Life Sciences Lung transplants Nephrology Patients Preeclampsia Pregnancy Quality of life Thoracic surgery Womens health |
| title | Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation: Experience of a Decade |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A48%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pregnancies%20and%20Gynecological%20Follow-Up%20after%20Solid%20Organ%20Transplantation:%20Experience%20of%20a%20Decade&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Bedin,%20Alice&rft.date=2022-08-16&rft.volume=11&rft.issue=16&rft.spage=4792&rft.pages=4792-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11164792&rft_dat=%3Cproquest_pubme%3E2707607371%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2706214299&rft_id=info:pmid/36013030&rfr_iscdi=true |