STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer
Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STE...
Gespeichert in:
| Veröffentlicht in: | Cancers 2022-08, Vol.14 (16), p.4034 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 16 |
| container_start_page | 4034 |
| container_title | Cancers |
| container_volume | 14 |
| creator | Xu, Michael Evans, Latese Bizzaro, Candice L Quaglia, Fabio Verrillo, Cecilia E Li, Li Stieglmaier, Julia Schiewer, Matthew J Languino, Lucia R Kelly, William K |
| description | Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1–4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1–4 as potential biomarkers and therapeutic targets for prostate cancer. In particular, STEAP1 is the target of many emerging immunotherapies. Herein, we give an overview of the structure, physiology, and pathophysiology of STEAP1–4 to provide context for past and current efforts to translate STEAP1–4 into the clinic. |
| doi_str_mv | 10.3390/cancers14164034 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9406800</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A745271382</galeid><sourcerecordid>A745271382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-c37f0860c0a05cf0d0bcd17441525403a077f1a017294a1aced16497ab3dfdeb3</originalsourceid><addsrcrecordid>eNptUk1rGzEQFaWlCW7OvQp6SQ-b6Gsl76VgjJsGAg3EOQutdmQr7EqutC4NufQ_5B_2l1R2QtOESIcZRu-90TwGoY-UnHDekFNrgoWUqaBSEC7eoENGFKukbMTb__IDdJTzDSmHc6qkeo8OuCSUEqYO0d3VcjG7pH9-3wt8fOV_VctkQh5gaEsEvNj4cQ29Nz2ehdGvIODocCnhyxTzaEbAe-5nbEKHl2vwCc97H7wtjPNh05dk9DFk7GJ64sz3P_-A3jnTZzh6jBN0_XWxnH-rLr6fnc9nF5UVsh4ry5UjU0ksMaS2jnSktR1VQtCa1WVwQ5Ry1BCqWCMMNRa6YkijTMs710HLJ-jLg-5m2w7QWQhjMr3eJD-YdKuj8fr5S_BrvYo_dSOInBbbJuj4USDFH1vIox58ttD3xaK4zZopomQxdMoK9NML6E3cplDG26EkZXUjmyfUyvSgfXCx9LU7UT1TomaK8r3WySuocjsYvI0BnC_1Z4TTB4ItRucE7t-MlOjdyugXK8P_Aqwcs9I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2706125969</pqid></control><display><type>article</type><title>STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Xu, Michael ; Evans, Latese ; Bizzaro, Candice L ; Quaglia, Fabio ; Verrillo, Cecilia E ; Li, Li ; Stieglmaier, Julia ; Schiewer, Matthew J ; Languino, Lucia R ; Kelly, William K</creator><creatorcontrib>Xu, Michael ; Evans, Latese ; Bizzaro, Candice L ; Quaglia, Fabio ; Verrillo, Cecilia E ; Li, Li ; Stieglmaier, Julia ; Schiewer, Matthew J ; Languino, Lucia R ; Kelly, William K</creatorcontrib><description>Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1–4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1–4 as potential biomarkers and therapeutic targets for prostate cancer. In particular, STEAP1 is the target of many emerging immunotherapies. Herein, we give an overview of the structure, physiology, and pathophysiology of STEAP1–4 to provide context for past and current efforts to translate STEAP1–4 into the clinic.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14164034</identifier><identifier>PMID: 36011027</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acids ; Androgens ; Antigens ; Biomarkers ; Cancer therapies ; Cancer vaccines ; Care and treatment ; Castration ; Communication ; Health aspects ; Homeostasis ; Immunotherapy ; Medical prognosis ; Metabolism ; Metastases ; Metastasis ; Morbidity ; Physiology ; Prostate cancer ; Proteins ; Review ; Therapeutic applications ; Therapeutic targets ; Vaccines</subject><ispartof>Cancers, 2022-08, Vol.14 (16), p.4034</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c37f0860c0a05cf0d0bcd17441525403a077f1a017294a1aced16497ab3dfdeb3</citedby><cites>FETCH-LOGICAL-c465t-c37f0860c0a05cf0d0bcd17441525403a077f1a017294a1aced16497ab3dfdeb3</cites><orcidid>0000-0002-1801-2611</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406800/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406800/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Xu, Michael</creatorcontrib><creatorcontrib>Evans, Latese</creatorcontrib><creatorcontrib>Bizzaro, Candice L</creatorcontrib><creatorcontrib>Quaglia, Fabio</creatorcontrib><creatorcontrib>Verrillo, Cecilia E</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Stieglmaier, Julia</creatorcontrib><creatorcontrib>Schiewer, Matthew J</creatorcontrib><creatorcontrib>Languino, Lucia R</creatorcontrib><creatorcontrib>Kelly, William K</creatorcontrib><title>STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer</title><title>Cancers</title><description>Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1–4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1–4 as potential biomarkers and therapeutic targets for prostate cancer. In particular, STEAP1 is the target of many emerging immunotherapies. Herein, we give an overview of the structure, physiology, and pathophysiology of STEAP1–4 to provide context for past and current efforts to translate STEAP1–4 into the clinic.</description><subject>Acids</subject><subject>Androgens</subject><subject>Antigens</subject><subject>Biomarkers</subject><subject>Cancer therapies</subject><subject>Cancer vaccines</subject><subject>Care and treatment</subject><subject>Castration</subject><subject>Communication</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Immunotherapy</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Morbidity</subject><subject>Physiology</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Review</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Vaccines</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk1rGzEQFaWlCW7OvQp6SQ-b6Gsl76VgjJsGAg3EOQutdmQr7EqutC4NufQ_5B_2l1R2QtOESIcZRu-90TwGoY-UnHDekFNrgoWUqaBSEC7eoENGFKukbMTb__IDdJTzDSmHc6qkeo8OuCSUEqYO0d3VcjG7pH9-3wt8fOV_VctkQh5gaEsEvNj4cQ29Nz2ehdGvIODocCnhyxTzaEbAe-5nbEKHl2vwCc97H7wtjPNh05dk9DFk7GJ64sz3P_-A3jnTZzh6jBN0_XWxnH-rLr6fnc9nF5UVsh4ry5UjU0ksMaS2jnSktR1VQtCa1WVwQ5Ry1BCqWCMMNRa6YkijTMs710HLJ-jLg-5m2w7QWQhjMr3eJD-YdKuj8fr5S_BrvYo_dSOInBbbJuj4USDFH1vIox58ttD3xaK4zZopomQxdMoK9NML6E3cplDG26EkZXUjmyfUyvSgfXCx9LU7UT1TomaK8r3WySuocjsYvI0BnC_1Z4TTB4ItRucE7t-MlOjdyugXK8P_Aqwcs9I</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Xu, Michael</creator><creator>Evans, Latese</creator><creator>Bizzaro, Candice L</creator><creator>Quaglia, Fabio</creator><creator>Verrillo, Cecilia E</creator><creator>Li, Li</creator><creator>Stieglmaier, Julia</creator><creator>Schiewer, Matthew J</creator><creator>Languino, Lucia R</creator><creator>Kelly, William K</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1801-2611</orcidid></search><sort><creationdate>20220801</creationdate><title>STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer</title><author>Xu, Michael ; Evans, Latese ; Bizzaro, Candice L ; Quaglia, Fabio ; Verrillo, Cecilia E ; Li, Li ; Stieglmaier, Julia ; Schiewer, Matthew J ; Languino, Lucia R ; Kelly, William K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c37f0860c0a05cf0d0bcd17441525403a077f1a017294a1aced16497ab3dfdeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>Androgens</topic><topic>Antigens</topic><topic>Biomarkers</topic><topic>Cancer therapies</topic><topic>Cancer vaccines</topic><topic>Care and treatment</topic><topic>Castration</topic><topic>Communication</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Immunotherapy</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Morbidity</topic><topic>Physiology</topic><topic>Prostate cancer</topic><topic>Proteins</topic><topic>Review</topic><topic>Therapeutic applications</topic><topic>Therapeutic targets</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Michael</creatorcontrib><creatorcontrib>Evans, Latese</creatorcontrib><creatorcontrib>Bizzaro, Candice L</creatorcontrib><creatorcontrib>Quaglia, Fabio</creatorcontrib><creatorcontrib>Verrillo, Cecilia E</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Stieglmaier, Julia</creatorcontrib><creatorcontrib>Schiewer, Matthew J</creatorcontrib><creatorcontrib>Languino, Lucia R</creatorcontrib><creatorcontrib>Kelly, William K</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Michael</au><au>Evans, Latese</au><au>Bizzaro, Candice L</au><au>Quaglia, Fabio</au><au>Verrillo, Cecilia E</au><au>Li, Li</au><au>Stieglmaier, Julia</au><au>Schiewer, Matthew J</au><au>Languino, Lucia R</au><au>Kelly, William K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer</atitle><jtitle>Cancers</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>14</volume><issue>16</issue><spage>4034</spage><pages>4034-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1–4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1–4 as potential biomarkers and therapeutic targets for prostate cancer. In particular, STEAP1 is the target of many emerging immunotherapies. Herein, we give an overview of the structure, physiology, and pathophysiology of STEAP1–4 to provide context for past and current efforts to translate STEAP1–4 into the clinic.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36011027</pmid><doi>10.3390/cancers14164034</doi><orcidid>https://orcid.org/0000-0002-1801-2611</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2022-08, Vol.14 (16), p.4034 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9406800 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acids Androgens Antigens Biomarkers Cancer therapies Cancer vaccines Care and treatment Castration Communication Health aspects Homeostasis Immunotherapy Medical prognosis Metabolism Metastases Metastasis Morbidity Physiology Prostate cancer Proteins Review Therapeutic applications Therapeutic targets Vaccines |
| title | STEAP1–4 (Six-Transmembrane Epithelial Antigen of the Prostate 1–4) and Their Clinical Implications for Prostate Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T15%3A30%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=STEAP1%E2%80%934%20(Six-Transmembrane%20Epithelial%20Antigen%20of%20the%20Prostate%201%E2%80%934)%20and%20Their%20Clinical%20Implications%20for%20Prostate%20Cancer&rft.jtitle=Cancers&rft.au=Xu,%20Michael&rft.date=2022-08-01&rft.volume=14&rft.issue=16&rft.spage=4034&rft.pages=4034-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers14164034&rft_dat=%3Cgale_pubme%3EA745271382%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2706125969&rft_id=info:pmid/36011027&rft_galeid=A745271382&rfr_iscdi=true |