Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow with 5-year overall survival of less than 10% in patients over the age of 65. Limited progress has been made in the patient outcome because of the inability to selectively eradicate the leukemic stem cells (LSC) driving the...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2022-08, Vol.40 (8), p.736-750
Hauptverfasser:	Lewis, Andrew Henry, Bridges, Cory Seth, Moorshead, David Neal, Chen, Taylor J, Du, Wa, Zorman, Barry, Sumazin, Pavel, Puppi, Monica, Lacorazza, H Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - pathology Cancer Stem Cells Disease Models, Animal Kruppel-Like Factor 4 Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Mice Myeloid-Lymphoid Leukemia Protein - metabolism Neoplastic Stem Cells - metabolism Oncogene Proteins, Fusion - metabolism
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