Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia

We showed previously that the ABL-mediated phosphorylation of SOS1 promotes RAC activation and contributes to BCR-ABL leukemogenesis, suggesting the relevant role of SOS1 in the pathogenesis of CML. To try and obtain direct experimental evidence of the specific mechanistic implication of SOS1 in CML...

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Veröffentlicht in:	Cancers 2022-08, Vol.14 (16), p.3893
Hauptverfasser:	Gómez, Carmela, Garcia-Navas, Rósula, Baltanás, Fernando C, Fuentes-Mateos, Rocío, Fernández-Medarde, Alberto, Calzada, Nuria, Santos, Eugenio
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animal models Animals BCR-ABL protein BCR-ABL1 gene Blood Bone marrow Cellular proteins Chromosomes Chronic myeloid leukemia Development and progression Disease Fusion protein Genetic aspects Granulocytes Health aspects Kinases Leukemia Leukemogenesis Malignancy Mutation Myeloid leukemia Osteoprogenitor cells Pathogenesis Phosphorylation Progenitor cells Proteins Rodents Splenomegaly Stem cells Therapeutic applications Therapeutic targets Transgenic mice
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