Fe( iii )-catalysed selective C–N bond cleavage of N -phenylamides by an electrochemical method

Fe( iii )-catalysed selective C–N bond cleavage of N -phenylamides by an electrochemical method

An Fe( iii )-catalysed transformation of secondary N -phenyl substituted amides to primary amides by an electrochemical method is developed. Regioselective aryl C–H oxygenation occurs during the reaction, promoting selective C(phenyl)-N bond cleavage to form primary amides in yields of up to 92%.

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Veröffentlicht in:RSC advances 2022-08, Vol.12 (37), p.24217-24221
Hauptverfasser: Xu, Yiwen, Long, Yang, Ye, Runyou, Li, Qiang, Ke, Fang, Zhou, Xiangge
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Chemistry
Cleavage
Oxygenation
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Zusammenfassung:An Fe( iii )-catalysed transformation of secondary N -phenyl substituted amides to primary amides by an electrochemical method is developed. Regioselective aryl C–H oxygenation occurs during the reaction, promoting selective C(phenyl)-N bond cleavage to form primary amides in yields of up to 92%.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra04709h