Association Between Changes in Alcohol Consumption and Cancer Risk
Importance Although numerous studies have shown an association between alcohol consumption and cancer, how changes in drinking behavior increase or decrease the incidence of cancer is not well understood. Objective To investigate the association between the reduction, cessation, or increase of alcoh...
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| Veröffentlicht in: | JAMA network open 2022-08, Vol.5 (8), p.e2228544-e2228544 |
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| creator | Yoo, Jung Eun Han, Kyungdo Shin, Dong Wook Kim, Dahye Kim, Bong-seong Chun, Sohyun Jeon, Keun Hye Jung, Wonyoung Park, Jinsung Park, Jin Ho Choi, Kui Son Kim, Joo Sung |
| description | Importance Although numerous studies have shown an association between alcohol consumption and cancer, how changes in drinking behavior increase or decrease the incidence of cancer is not well understood. Objective To investigate the association between the reduction, cessation, or increase of alcohol consumption and the development of alcohol-related cancers and all cancers. Design, Setting, and Participants This population-based cohort study analyzed adult beneficiaries in the Korean National Health Insurance Service. Participants (aged ≥40 years) included those who underwent a national health screening in both 2009 and 2011 and had available data on their drinking status. Data were analyzed from April 16 to July 6, 2020. Exposures Alcohol consumption level, which was self-reported by participants in health screening questionnaires, was categorized into none (0 g/d), mild ( |
| doi_str_mv | 10.1001/jamanetworkopen.2022.28544 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9403779</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2706181759</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-7dd3b0847d849031118a5c0427d793d2874398c849ded474af3d3e857298dde3</originalsourceid><addsrcrecordid>eNpdkVtLwzAYhoMobsz9h6I33nTm1Cb1QtiKJxgIsvuQJdnWrU1q0ir-e9ttiO7q--B9eL_DC8A1ghMEIbrbykpa03w5v3O1sRMMMZ5gnlB6BoY4YTQmHCbnf_oBGIewhRBiiEiWJpdgQNLOiiAyBLNpCE4VsimcjWadrzE2yjfSrk2IChtNS-U2roxyZ0Nb1XtMWh3l0irjo_ci7K7AxUqWwYyPdQQWT4-L_CWevz2_5tN5rChBTcy0JkvIKdOcZpAghLhMFKSYaZYRjTmjJOOqE7XRlFG5IpoYnjCcca0NGYGHg23dLiujlbGNl6WofVFJ_y2cLMR_xRYbsXafIqOQsG7ECNweDbz7aE1oRFUEZcqy-6drg8AMpogjlvTozQm6da233XUdRVLOGMc9dX-glHcheLP6XQZB0YclTsISfVhiHxb5AQYYivA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2736877829</pqid></control><display><type>article</type><title>Association Between Changes in Alcohol Consumption and Cancer Risk</title><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Yoo, Jung Eun ; Han, Kyungdo ; Shin, Dong Wook ; Kim, Dahye ; Kim, Bong-seong ; Chun, Sohyun ; Jeon, Keun Hye ; Jung, Wonyoung ; Park, Jinsung ; Park, Jin Ho ; Choi, Kui Son ; Kim, Joo Sung</creator><creatorcontrib>Yoo, Jung Eun ; Han, Kyungdo ; Shin, Dong Wook ; Kim, Dahye ; Kim, Bong-seong ; Chun, Sohyun ; Jeon, Keun Hye ; Jung, Wonyoung ; Park, Jinsung ; Park, Jin Ho ; Choi, Kui Son ; Kim, Joo Sung</creatorcontrib><description>Importance Although numerous studies have shown an association between alcohol consumption and cancer, how changes in drinking behavior increase or decrease the incidence of cancer is not well understood. Objective To investigate the association between the reduction, cessation, or increase of alcohol consumption and the development of alcohol-related cancers and all cancers. Design, Setting, and Participants This population-based cohort study analyzed adult beneficiaries in the Korean National Health Insurance Service. Participants (aged ≥40 years) included those who underwent a national health screening in both 2009 and 2011 and had available data on their drinking status. Data were analyzed from April 16 to July 6, 2020. Exposures Alcohol consumption level, which was self-reported by participants in health screening questionnaires, was categorized into none (0 g/d), mild (<15 g/d), moderate (15-29.9 g/d), and heavy (≥30 g/d) drinking. Based on changes in alcohol consumption level from 2009 to 2011, participants were categorized into the following groups: nondrinker, sustainer, increaser, quitter, and reducer. Main Outcomes and Measures The primary outcome was newly diagnosed alcohol-related cancers (including cancers of the head and neck, esophagus, colorectum, liver, larynx, and female breast), and the secondary outcome was all newly diagnosed cancers (except for thyroid cancer). Results Among the 4 513 746 participants (mean [SD] age, 53.6 [9.6] years; 2 324 172 [51.5%] men), the incidence rate of cancer was 7.7 per 1000 person-years during a median (IQR) follow-up of 6.4 (6.1-6.6) years. Compared with the sustainer groups at each drinking level, the increaser groups had a higher risk of alcohol-related cancers and all cancers. The increased alcohol-related cancer incidence was associated with dose; those who changed from nondrinking to mild (adjusted hazard ratio [aHR], 1.03; 95% CI, 1.00-1.06), moderate (aHR, 1.10; 95% CI, 1.02-1.18), or heavy (aHR, 1.34; 95% CI, 1.23-1.45) drinking levels had an associated higher risk than those who did not drink. Those with mild drinking levels who quit drinking had a lower risk of alcohol-related cancer (aHR, 0.96; 95% CI, 0.92-0.99) than those who sustained their drinking levels. Those with moderate (aHR, 1.07; 95% CI, 1.03-1.12) or heavy (aHR, 1.07; 95% CI, 1.02-1.12) drinking levels who quit drinking had a higher all cancer incidence than those who sustained their levels, but when quitting was sustained, this increase in risk disappeared. Compared with sustained heavy drinking, reduced heavy drinking levels to moderate levels (alcohol-related cancer: aHR, 0.91 [95% CI, 0.86-0.97]; all cancers: aHR, 0.96 [95% CI, 0.92-0.99]) or mild levels (alcohol-related cancer: aHR, 0.92 [95% CI, 0.86-0.98]; all cancers: aHR, 0.92 [95% CI, 0.89-0.96]) were associated with decreased cancer risk. Conclusions and Relevance Results of this study showed that increased alcohol consumption was associated with higher risks for alcohol-related and all cancers, whereas sustained quitting and reduced drinking were associated with lower risks of alcohol-related and all cancers. Alcohol cessation and reduction should be reinforced for the prevention of cancer.</description><identifier>ISSN: 2574-3805</identifier><identifier>EISSN: 2574-3805</identifier><identifier>DOI: 10.1001/jamanetworkopen.2022.28544</identifier><identifier>PMID: 36001313</identifier><language>eng</language><publisher>Chicago: American Medical Association</publisher><subject>Alcohol ; Alcohol use ; Cancer ; Medical screening ; Oncology ; Online Only ; Original Investigation</subject><ispartof>JAMA network open, 2022-08, Vol.5 (8), p.e2228544-e2228544</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2022 Yoo JE et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-7dd3b0847d849031118a5c0427d793d2874398c849ded474af3d3e857298dde3</citedby><cites>FETCH-LOGICAL-c431t-7dd3b0847d849031118a5c0427d793d2874398c849ded474af3d3e857298dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,861,882,27905,27906</link.rule.ids></links><search><creatorcontrib>Yoo, Jung Eun</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Kim, Dahye</creatorcontrib><creatorcontrib>Kim, Bong-seong</creatorcontrib><creatorcontrib>Chun, Sohyun</creatorcontrib><creatorcontrib>Jeon, Keun Hye</creatorcontrib><creatorcontrib>Jung, Wonyoung</creatorcontrib><creatorcontrib>Park, Jinsung</creatorcontrib><creatorcontrib>Park, Jin Ho</creatorcontrib><creatorcontrib>Choi, Kui Son</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><title>Association Between Changes in Alcohol Consumption and Cancer Risk</title><title>JAMA network open</title><description>Importance Although numerous studies have shown an association between alcohol consumption and cancer, how changes in drinking behavior increase or decrease the incidence of cancer is not well understood. Objective To investigate the association between the reduction, cessation, or increase of alcohol consumption and the development of alcohol-related cancers and all cancers. Design, Setting, and Participants This population-based cohort study analyzed adult beneficiaries in the Korean National Health Insurance Service. Participants (aged ≥40 years) included those who underwent a national health screening in both 2009 and 2011 and had available data on their drinking status. Data were analyzed from April 16 to July 6, 2020. Exposures Alcohol consumption level, which was self-reported by participants in health screening questionnaires, was categorized into none (0 g/d), mild (<15 g/d), moderate (15-29.9 g/d), and heavy (≥30 g/d) drinking. Based on changes in alcohol consumption level from 2009 to 2011, participants were categorized into the following groups: nondrinker, sustainer, increaser, quitter, and reducer. Main Outcomes and Measures The primary outcome was newly diagnosed alcohol-related cancers (including cancers of the head and neck, esophagus, colorectum, liver, larynx, and female breast), and the secondary outcome was all newly diagnosed cancers (except for thyroid cancer). Results Among the 4 513 746 participants (mean [SD] age, 53.6 [9.6] years; 2 324 172 [51.5%] men), the incidence rate of cancer was 7.7 per 1000 person-years during a median (IQR) follow-up of 6.4 (6.1-6.6) years. Compared with the sustainer groups at each drinking level, the increaser groups had a higher risk of alcohol-related cancers and all cancers. The increased alcohol-related cancer incidence was associated with dose; those who changed from nondrinking to mild (adjusted hazard ratio [aHR], 1.03; 95% CI, 1.00-1.06), moderate (aHR, 1.10; 95% CI, 1.02-1.18), or heavy (aHR, 1.34; 95% CI, 1.23-1.45) drinking levels had an associated higher risk than those who did not drink. Those with mild drinking levels who quit drinking had a lower risk of alcohol-related cancer (aHR, 0.96; 95% CI, 0.92-0.99) than those who sustained their drinking levels. Those with moderate (aHR, 1.07; 95% CI, 1.03-1.12) or heavy (aHR, 1.07; 95% CI, 1.02-1.12) drinking levels who quit drinking had a higher all cancer incidence than those who sustained their levels, but when quitting was sustained, this increase in risk disappeared. Compared with sustained heavy drinking, reduced heavy drinking levels to moderate levels (alcohol-related cancer: aHR, 0.91 [95% CI, 0.86-0.97]; all cancers: aHR, 0.96 [95% CI, 0.92-0.99]) or mild levels (alcohol-related cancer: aHR, 0.92 [95% CI, 0.86-0.98]; all cancers: aHR, 0.92 [95% CI, 0.89-0.96]) were associated with decreased cancer risk. Conclusions and Relevance Results of this study showed that increased alcohol consumption was associated with higher risks for alcohol-related and all cancers, whereas sustained quitting and reduced drinking were associated with lower risks of alcohol-related and all cancers. Alcohol cessation and reduction should be reinforced for the prevention of cancer.</description><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Cancer</subject><subject>Medical screening</subject><subject>Oncology</subject><subject>Online Only</subject><subject>Original Investigation</subject><issn>2574-3805</issn><issn>2574-3805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkVtLwzAYhoMobsz9h6I33nTm1Cb1QtiKJxgIsvuQJdnWrU1q0ir-e9ttiO7q--B9eL_DC8A1ghMEIbrbykpa03w5v3O1sRMMMZ5gnlB6BoY4YTQmHCbnf_oBGIewhRBiiEiWJpdgQNLOiiAyBLNpCE4VsimcjWadrzE2yjfSrk2IChtNS-U2roxyZ0Nb1XtMWh3l0irjo_ci7K7AxUqWwYyPdQQWT4-L_CWevz2_5tN5rChBTcy0JkvIKdOcZpAghLhMFKSYaZYRjTmjJOOqE7XRlFG5IpoYnjCcca0NGYGHg23dLiujlbGNl6WofVFJ_y2cLMR_xRYbsXafIqOQsG7ECNweDbz7aE1oRFUEZcqy-6drg8AMpogjlvTozQm6da233XUdRVLOGMc9dX-glHcheLP6XQZB0YclTsISfVhiHxb5AQYYivA</recordid><startdate>20220824</startdate><enddate>20220824</enddate><creator>Yoo, Jung Eun</creator><creator>Han, Kyungdo</creator><creator>Shin, Dong Wook</creator><creator>Kim, Dahye</creator><creator>Kim, Bong-seong</creator><creator>Chun, Sohyun</creator><creator>Jeon, Keun Hye</creator><creator>Jung, Wonyoung</creator><creator>Park, Jinsung</creator><creator>Park, Jin Ho</creator><creator>Choi, Kui Son</creator><creator>Kim, Joo Sung</creator><general>American Medical Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220824</creationdate><title>Association Between Changes in Alcohol Consumption and Cancer Risk</title><author>Yoo, Jung Eun ; Han, Kyungdo ; Shin, Dong Wook ; Kim, Dahye ; Kim, Bong-seong ; Chun, Sohyun ; Jeon, Keun Hye ; Jung, Wonyoung ; Park, Jinsung ; Park, Jin Ho ; Choi, Kui Son ; Kim, Joo Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-7dd3b0847d849031118a5c0427d793d2874398c849ded474af3d3e857298dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Cancer</topic><topic>Medical screening</topic><topic>Oncology</topic><topic>Online Only</topic><topic>Original Investigation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Jung Eun</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Kim, Dahye</creatorcontrib><creatorcontrib>Kim, Bong-seong</creatorcontrib><creatorcontrib>Chun, Sohyun</creatorcontrib><creatorcontrib>Jeon, Keun Hye</creatorcontrib><creatorcontrib>Jung, Wonyoung</creatorcontrib><creatorcontrib>Park, Jinsung</creatorcontrib><creatorcontrib>Park, Jin Ho</creatorcontrib><creatorcontrib>Choi, Kui Son</creatorcontrib><creatorcontrib>Kim, Joo Sung</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA network open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Jung Eun</au><au>Han, Kyungdo</au><au>Shin, Dong Wook</au><au>Kim, Dahye</au><au>Kim, Bong-seong</au><au>Chun, Sohyun</au><au>Jeon, Keun Hye</au><au>Jung, Wonyoung</au><au>Park, Jinsung</au><au>Park, Jin Ho</au><au>Choi, Kui Son</au><au>Kim, Joo Sung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Changes in Alcohol Consumption and Cancer Risk</atitle><jtitle>JAMA network open</jtitle><date>2022-08-24</date><risdate>2022</risdate><volume>5</volume><issue>8</issue><spage>e2228544</spage><epage>e2228544</epage><pages>e2228544-e2228544</pages><issn>2574-3805</issn><eissn>2574-3805</eissn><abstract>Importance Although numerous studies have shown an association between alcohol consumption and cancer, how changes in drinking behavior increase or decrease the incidence of cancer is not well understood. Objective To investigate the association between the reduction, cessation, or increase of alcohol consumption and the development of alcohol-related cancers and all cancers. Design, Setting, and Participants This population-based cohort study analyzed adult beneficiaries in the Korean National Health Insurance Service. Participants (aged ≥40 years) included those who underwent a national health screening in both 2009 and 2011 and had available data on their drinking status. Data were analyzed from April 16 to July 6, 2020. Exposures Alcohol consumption level, which was self-reported by participants in health screening questionnaires, was categorized into none (0 g/d), mild (<15 g/d), moderate (15-29.9 g/d), and heavy (≥30 g/d) drinking. Based on changes in alcohol consumption level from 2009 to 2011, participants were categorized into the following groups: nondrinker, sustainer, increaser, quitter, and reducer. Main Outcomes and Measures The primary outcome was newly diagnosed alcohol-related cancers (including cancers of the head and neck, esophagus, colorectum, liver, larynx, and female breast), and the secondary outcome was all newly diagnosed cancers (except for thyroid cancer). Results Among the 4 513 746 participants (mean [SD] age, 53.6 [9.6] years; 2 324 172 [51.5%] men), the incidence rate of cancer was 7.7 per 1000 person-years during a median (IQR) follow-up of 6.4 (6.1-6.6) years. Compared with the sustainer groups at each drinking level, the increaser groups had a higher risk of alcohol-related cancers and all cancers. The increased alcohol-related cancer incidence was associated with dose; those who changed from nondrinking to mild (adjusted hazard ratio [aHR], 1.03; 95% CI, 1.00-1.06), moderate (aHR, 1.10; 95% CI, 1.02-1.18), or heavy (aHR, 1.34; 95% CI, 1.23-1.45) drinking levels had an associated higher risk than those who did not drink. Those with mild drinking levels who quit drinking had a lower risk of alcohol-related cancer (aHR, 0.96; 95% CI, 0.92-0.99) than those who sustained their drinking levels. Those with moderate (aHR, 1.07; 95% CI, 1.03-1.12) or heavy (aHR, 1.07; 95% CI, 1.02-1.12) drinking levels who quit drinking had a higher all cancer incidence than those who sustained their levels, but when quitting was sustained, this increase in risk disappeared. Compared with sustained heavy drinking, reduced heavy drinking levels to moderate levels (alcohol-related cancer: aHR, 0.91 [95% CI, 0.86-0.97]; all cancers: aHR, 0.96 [95% CI, 0.92-0.99]) or mild levels (alcohol-related cancer: aHR, 0.92 [95% CI, 0.86-0.98]; all cancers: aHR, 0.92 [95% CI, 0.89-0.96]) were associated with decreased cancer risk. Conclusions and Relevance Results of this study showed that increased alcohol consumption was associated with higher risks for alcohol-related and all cancers, whereas sustained quitting and reduced drinking were associated with lower risks of alcohol-related and all cancers. Alcohol cessation and reduction should be reinforced for the prevention of cancer.</abstract><cop>Chicago</cop><pub>American Medical Association</pub><pmid>36001313</pmid><doi>10.1001/jamanetworkopen.2022.28544</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Alcohol use Cancer Medical screening Oncology Online Only Original Investigation |
| title | Association Between Changes in Alcohol Consumption and Cancer Risk |
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