Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women’s Interagency HIV Study
Abstract Background We previously reported lower bone mineral density (BMD) among premenopausal women with HIV (WWH) compared to women without HIV (HIV−). Rate of bone loss may be even greater for WWH during the menopausal transition. Methods Pre-, peri- and postmenopausal women in the Women\'s...
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| Veröffentlicht in: | Clinical infectious diseases 2022-08, Vol.75 (1), p.65-72 |
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| creator | Sharma, Anjali Hoover, Donald R Shi, Qiuhu Tien, Phyllis C Weber, Kathleen M Shah, Jayesh G Yin, Michael T |
| description | Abstract
Background
We previously reported lower bone mineral density (BMD) among premenopausal women with HIV (WWH) compared to women without HIV (HIV−). Rate of bone loss may be even greater for WWH during the menopausal transition.
Methods
Pre-, peri- and postmenopausal women in the Women\'s Interagency HIV Study (WIHS) underwent whole body DXA and central quantitative computed tomography to measure areal BMD (aBMD) and volumetric BMD (vBMD), respectively. Multivariable regression models with covariates associated with low aBMD (T score < −1.0) in univariate analyses (P≤.05) and known risk factors for low BMD assessed contributions of HIV and menopausal stage to the prediction of aBMD.
Results
Compared to HIV− women, in unadjusted analyses, WWH had 5–9% lower aBMD at the lumbar spine (P=.001), femoral neck (P=.04), total hip (P=.003) and the ultradistal radius (P=.004), and higher osteoporosis prevalence (T score |
| doi_str_mv | 10.1093/cid/ciab874 |
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Background
We previously reported lower bone mineral density (BMD) among premenopausal women with HIV (WWH) compared to women without HIV (HIV−). Rate of bone loss may be even greater for WWH during the menopausal transition.
Methods
Pre-, peri- and postmenopausal women in the Women\'s Interagency HIV Study (WIHS) underwent whole body DXA and central quantitative computed tomography to measure areal BMD (aBMD) and volumetric BMD (vBMD), respectively. Multivariable regression models with covariates associated with low aBMD (T score < −1.0) in univariate analyses (P≤.05) and known risk factors for low BMD assessed contributions of HIV and menopausal stage to the prediction of aBMD.
Results
Compared to HIV− women, in unadjusted analyses, WWH had 5–9% lower aBMD at the lumbar spine (P=.001), femoral neck (P=.04), total hip (P=.003) and the ultradistal radius (P=.004), and higher osteoporosis prevalence (T score<−2.5) at the ultradistal radius only (13.5% vs 0%, P=.0003). WWH also had lower vBMD at the spine and hip. In fully adjusted models, HIV independently predicted reduced aBMD at the lumbar spine, total hip, femoral neck, and ultradistal radius; menopausal stage remained a significant predictor of lumbar spine and ultradistal radius aBMD.
Conclusions
HIV infection and menopausal stage were independent predictors of lower BMD, and had an additive effect on lumbar spine and total hip BMD. Additional research is needed to better understand underlying mechanisms by which HIV impacts BMD as women age and transition through menopause, and develop strategies to mitigate osteoporosis and fracture risk in this growing population.
Among pre-, peri- and postmenopausal women, low BMD was more common in women with HIV than without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciab874</identifier><identifier>PMID: 34595517</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Absorptiometry, Photon - methods ; Bone Density ; Female ; HIV ; HIV Infections - complications ; Humans ; Major ; Menopause ; Osteoporosis</subject><ispartof>Clinical infectious diseases, 2022-08, Vol.75 (1), p.65-72</ispartof><rights>The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-cb84bbac900c128c41f3dcf6ef331bd6b5385f4c677c1ba0533c27c51b84b1303</citedby><cites>FETCH-LOGICAL-c412t-cb84bbac900c128c41f3dcf6ef331bd6b5385f4c677c1ba0533c27c51b84b1303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,1586,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34595517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Anjali</creatorcontrib><creatorcontrib>Hoover, Donald R</creatorcontrib><creatorcontrib>Shi, Qiuhu</creatorcontrib><creatorcontrib>Tien, Phyllis C</creatorcontrib><creatorcontrib>Weber, Kathleen M</creatorcontrib><creatorcontrib>Shah, Jayesh G</creatorcontrib><creatorcontrib>Yin, Michael T</creatorcontrib><title>Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women’s Interagency HIV Study</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Background
We previously reported lower bone mineral density (BMD) among premenopausal women with HIV (WWH) compared to women without HIV (HIV−). Rate of bone loss may be even greater for WWH during the menopausal transition.
Methods
Pre-, peri- and postmenopausal women in the Women\'s Interagency HIV Study (WIHS) underwent whole body DXA and central quantitative computed tomography to measure areal BMD (aBMD) and volumetric BMD (vBMD), respectively. Multivariable regression models with covariates associated with low aBMD (T score < −1.0) in univariate analyses (P≤.05) and known risk factors for low BMD assessed contributions of HIV and menopausal stage to the prediction of aBMD.
Results
Compared to HIV− women, in unadjusted analyses, WWH had 5–9% lower aBMD at the lumbar spine (P=.001), femoral neck (P=.04), total hip (P=.003) and the ultradistal radius (P=.004), and higher osteoporosis prevalence (T score<−2.5) at the ultradistal radius only (13.5% vs 0%, P=.0003). WWH also had lower vBMD at the spine and hip. In fully adjusted models, HIV independently predicted reduced aBMD at the lumbar spine, total hip, femoral neck, and ultradistal radius; menopausal stage remained a significant predictor of lumbar spine and ultradistal radius aBMD.
Conclusions
HIV infection and menopausal stage were independent predictors of lower BMD, and had an additive effect on lumbar spine and total hip BMD. Additional research is needed to better understand underlying mechanisms by which HIV impacts BMD as women age and transition through menopause, and develop strategies to mitigate osteoporosis and fracture risk in this growing population.
Among pre-, peri- and postmenopausal women, low BMD was more common in women with HIV than without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.</description><subject>Absorptiometry, Photon - methods</subject><subject>Bone Density</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Major</subject><subject>Menopause</subject><subject>Osteoporosis</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAYhSMEohdYsUdeoSIUsOM4TrpAGgplRpoKiUu7tBznT8cosYMvRdnxGqx4N54EDzNUsGHhi-zP5xzrZNkjgp8T3NAXSndpyLbm5Z3skDDK84o15G7aY1bnZU3rg-zI-88YE1Jjdj87oCVrGCP8MPuxjKM0aDWO0dgOeq00GDWjS-2iRyfL1eVTJE2HLsDYSUYPaOEArUwHE6TJhGFGC-9tChCgQ1c6bNDafgWHXlkD6EIbcHJAr8F4HeZT9B58HIJH586OKGwAXdkRzM9v330SDYm9_m2ffNGHELv5QXavl4OHh_v1OPt0_ubj2TJfv3u7Olusc1WSIuSqrcu2larBWJGiToc97VRfQU8pabuqZbRmfakqzhVpJWaUqoIrRrbvCMX0OHu5051iO0Kn0s9SbjE5PUo3Cyu1-PfG6I24tjeiKXFR0SoJnOwFnP0SwQcxaq9gGKQBG70oGK855xXeos92qHLWewf9rQ3BYlupSJWKfaWJfvx3slv2T4cJeLIDbJz-q_QLp-Su1w</recordid><startdate>20220824</startdate><enddate>20220824</enddate><creator>Sharma, Anjali</creator><creator>Hoover, Donald R</creator><creator>Shi, Qiuhu</creator><creator>Tien, Phyllis C</creator><creator>Weber, Kathleen M</creator><creator>Shah, Jayesh G</creator><creator>Yin, Michael T</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220824</creationdate><title>Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women’s Interagency HIV Study</title><author>Sharma, Anjali ; Hoover, Donald R ; Shi, Qiuhu ; Tien, Phyllis C ; Weber, Kathleen M ; Shah, Jayesh G ; Yin, Michael T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-cb84bbac900c128c41f3dcf6ef331bd6b5385f4c677c1ba0533c27c51b84b1303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Bone Density</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Major</topic><topic>Menopause</topic><topic>Osteoporosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Anjali</creatorcontrib><creatorcontrib>Hoover, Donald R</creatorcontrib><creatorcontrib>Shi, Qiuhu</creatorcontrib><creatorcontrib>Tien, Phyllis C</creatorcontrib><creatorcontrib>Weber, Kathleen M</creatorcontrib><creatorcontrib>Shah, Jayesh G</creatorcontrib><creatorcontrib>Yin, Michael T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Anjali</au><au>Hoover, Donald R</au><au>Shi, Qiuhu</au><au>Tien, Phyllis C</au><au>Weber, Kathleen M</au><au>Shah, Jayesh G</au><au>Yin, Michael T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women’s Interagency HIV Study</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2022-08-24</date><risdate>2022</risdate><volume>75</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
Background
We previously reported lower bone mineral density (BMD) among premenopausal women with HIV (WWH) compared to women without HIV (HIV−). Rate of bone loss may be even greater for WWH during the menopausal transition.
Methods
Pre-, peri- and postmenopausal women in the Women\'s Interagency HIV Study (WIHS) underwent whole body DXA and central quantitative computed tomography to measure areal BMD (aBMD) and volumetric BMD (vBMD), respectively. Multivariable regression models with covariates associated with low aBMD (T score < −1.0) in univariate analyses (P≤.05) and known risk factors for low BMD assessed contributions of HIV and menopausal stage to the prediction of aBMD.
Results
Compared to HIV− women, in unadjusted analyses, WWH had 5–9% lower aBMD at the lumbar spine (P=.001), femoral neck (P=.04), total hip (P=.003) and the ultradistal radius (P=.004), and higher osteoporosis prevalence (T score<−2.5) at the ultradistal radius only (13.5% vs 0%, P=.0003). WWH also had lower vBMD at the spine and hip. In fully adjusted models, HIV independently predicted reduced aBMD at the lumbar spine, total hip, femoral neck, and ultradistal radius; menopausal stage remained a significant predictor of lumbar spine and ultradistal radius aBMD.
Conclusions
HIV infection and menopausal stage were independent predictors of lower BMD, and had an additive effect on lumbar spine and total hip BMD. Additional research is needed to better understand underlying mechanisms by which HIV impacts BMD as women age and transition through menopause, and develop strategies to mitigate osteoporosis and fracture risk in this growing population.
Among pre-, peri- and postmenopausal women, low BMD was more common in women with HIV than without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34595517</pmid><doi>10.1093/cid/ciab874</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 2022-08, Vol.75 (1), p.65-72 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon - methods Bone Density Female HIV HIV Infections - complications Humans Major Menopause Osteoporosis |
| title | Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women’s Interagency HIV Study |
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