Native Ambient Mass Spectrometry of an Intact Membrane Protein Assembly and Soluble Protein Assemblies Directly from Lens Tissue

Membrane proteins constitute around two‐thirds of therapeutic targets but present a significant challenge for structural analysis due to their low abundance and solubility. Existing methods for structural analysis rely on over‐expression and/or purification of the membrane protein, thus removing any...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-08, Vol.61 (31), p.e202201458-n/a
Hauptverfasser:	Hale, Oliver J., Cooper, Helen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambient Mass Spectrometry Animals Aquaporin Assemblies Assembly Communication Communications Eye lens Helices Lens, Crystalline - metabolism Lenses Mass spectrometry Mass Spectrometry - methods Mass Spectrometry Imaging Mass spectroscopy Membrane Protein Membrane proteins Membrane Proteins - chemistry Membranes Native Mass Spectrometry Protein purification Proteins Sheep Spatial distribution Spectroscopy Structural analysis Therapeutic targets Tissues
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