Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context
Abstract Background Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. Methods Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were d...
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| Veröffentlicht in: | The Journal of infectious diseases 2022-08, Vol.226 (2), p.352-356 |
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| creator | Nkuba-Ndaye, Antoine Mukadi-Bamuleka, Daniel Bulabula-Penge, Junior Thaurignac, Guillaume Edidi-Atani, François Mambu-Mbika, Fabrice Danga-Yema, Bernice Matondo-Kuamfumu, Meris Kinganda-Lusamaki, Eddy Bisento, Nella Lumembe-Numbi, Raphaël Kabamba-Lungenyi, Gabriel Kitsa-Mutsumbirwa, Divine Kambale-Sivihwa, Nelson Boillot, François Delaporte, Eric Mbala-Kingebeni, Placide Ayouba, Ahidjo Peeters, Martine Ahuka-Mundeke, Steve |
| description | Abstract
Background
Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.
Methods
Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.
Results
After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.
Conclusions
These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
In clinically suspected EVD patients, EVD may be missed and inadvertently cause EBOV resurgence. Thus, surveillance during and after outbreaks should be extended to EBOV household contacts and to patients discharged as negative with an accurate serologic assay. |
| doi_str_mv | 10.1093/infdis/jiac057 |
| format | Article |
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Background
Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.
Methods
Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.
Results
After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.
Conclusions
These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
In clinically suspected EVD patients, EVD may be missed and inadvertently cause EBOV resurgence. Thus, surveillance during and after outbreaks should be extended to EBOV household contacts and to patients discharged as negative with an accurate serologic assay.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiac057</identifier><identifier>PMID: 35176762</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Antigens ; Brief Report ; Disease transmission ; Ebola virus ; Ebolavirus ; Epidemics ; Serology ; Survivor ; Viruses</subject><ispartof>The Journal of infectious diseases, 2022-08, Vol.226 (2), p.352-356</ispartof><rights>The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-47d16e6024aa3eb30a1520f92862f0b95494a68cafcc54ac88841487a60645e93</citedby><cites>FETCH-LOGICAL-c429t-47d16e6024aa3eb30a1520f92862f0b95494a68cafcc54ac88841487a60645e93</cites><orcidid>0000-0003-2850-7498 ; 0000-0002-5081-1632 ; 0000-0001-6738-8730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,1585,27929,27930</link.rule.ids></links><search><creatorcontrib>Nkuba-Ndaye, Antoine</creatorcontrib><creatorcontrib>Mukadi-Bamuleka, Daniel</creatorcontrib><creatorcontrib>Bulabula-Penge, Junior</creatorcontrib><creatorcontrib>Thaurignac, Guillaume</creatorcontrib><creatorcontrib>Edidi-Atani, François</creatorcontrib><creatorcontrib>Mambu-Mbika, Fabrice</creatorcontrib><creatorcontrib>Danga-Yema, Bernice</creatorcontrib><creatorcontrib>Matondo-Kuamfumu, Meris</creatorcontrib><creatorcontrib>Kinganda-Lusamaki, Eddy</creatorcontrib><creatorcontrib>Bisento, Nella</creatorcontrib><creatorcontrib>Lumembe-Numbi, Raphaël</creatorcontrib><creatorcontrib>Kabamba-Lungenyi, Gabriel</creatorcontrib><creatorcontrib>Kitsa-Mutsumbirwa, Divine</creatorcontrib><creatorcontrib>Kambale-Sivihwa, Nelson</creatorcontrib><creatorcontrib>Boillot, François</creatorcontrib><creatorcontrib>Delaporte, Eric</creatorcontrib><creatorcontrib>Mbala-Kingebeni, Placide</creatorcontrib><creatorcontrib>Ayouba, Ahidjo</creatorcontrib><creatorcontrib>Peeters, Martine</creatorcontrib><creatorcontrib>Ahuka-Mundeke, Steve</creatorcontrib><title>Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context</title><title>The Journal of infectious diseases</title><description>Abstract
Background
Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.
Methods
Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.
Results
After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.
Conclusions
These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
In clinically suspected EVD patients, EVD may be missed and inadvertently cause EBOV resurgence. Thus, surveillance during and after outbreaks should be extended to EBOV household contacts and to patients discharged as negative with an accurate serologic assay.</description><subject>Antigens</subject><subject>Brief Report</subject><subject>Disease transmission</subject><subject>Ebola virus</subject><subject>Ebolavirus</subject><subject>Epidemics</subject><subject>Serology</subject><subject>Survivor</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkU2P0zAQhiMEYsvClbMlLnDIru04jnNBqkr5kJYPaWGv1tSZpK4SO9jJiv4W_iwuqZDgwmkkz_O-M-M3y54zesVoXVxb1zY2Xh8sGFpWD7IVK4sql5IVD7MVpZznTNX1RfYkxgOlVBSyepxdFCWrZCX5Kvu5bhpsyB30MxLfEnBk7Sabb3e-B3KLwfe-O5LWBzLtkXwEBx0O6KYTvOmtswb6_khu5ziimZLVoryzYY7kjY0IEckXmGzS_H4wewhd4iCST9ilxj0S606Dt6NtcLCGbLyb8Mf0NHvUQh_x2bleZt_ebr9u3uc3n9992KxvciN4PeWiaphESbkAKHBXUGAlp23NleQt3dWlqAVIZaA1phRglFKCCVWBpFKUWBeX2evFd5x3AzYmbRqg12OwA4Sj9mD13x1n97rz97oW6Ue5SAYvzwbBf58xTnpId2Lfg0M_R81lkbKiSsiEvvgHPfg5uHSe5hVVLIWqWKKuFsoEH2PA9s8yjOpT7nrJXZ9zT4JXi8DP4__YXy35sP0</recordid><startdate>20220824</startdate><enddate>20220824</enddate><creator>Nkuba-Ndaye, Antoine</creator><creator>Mukadi-Bamuleka, Daniel</creator><creator>Bulabula-Penge, Junior</creator><creator>Thaurignac, Guillaume</creator><creator>Edidi-Atani, François</creator><creator>Mambu-Mbika, Fabrice</creator><creator>Danga-Yema, Bernice</creator><creator>Matondo-Kuamfumu, Meris</creator><creator>Kinganda-Lusamaki, Eddy</creator><creator>Bisento, Nella</creator><creator>Lumembe-Numbi, Raphaël</creator><creator>Kabamba-Lungenyi, Gabriel</creator><creator>Kitsa-Mutsumbirwa, Divine</creator><creator>Kambale-Sivihwa, Nelson</creator><creator>Boillot, François</creator><creator>Delaporte, Eric</creator><creator>Mbala-Kingebeni, Placide</creator><creator>Ayouba, Ahidjo</creator><creator>Peeters, Martine</creator><creator>Ahuka-Mundeke, Steve</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2850-7498</orcidid><orcidid>https://orcid.org/0000-0002-5081-1632</orcidid><orcidid>https://orcid.org/0000-0001-6738-8730</orcidid></search><sort><creationdate>20220824</creationdate><title>Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context</title><author>Nkuba-Ndaye, Antoine ; Mukadi-Bamuleka, Daniel ; Bulabula-Penge, Junior ; Thaurignac, Guillaume ; Edidi-Atani, François ; Mambu-Mbika, Fabrice ; Danga-Yema, Bernice ; Matondo-Kuamfumu, Meris ; Kinganda-Lusamaki, Eddy ; Bisento, Nella ; Lumembe-Numbi, Raphaël ; Kabamba-Lungenyi, Gabriel ; Kitsa-Mutsumbirwa, Divine ; Kambale-Sivihwa, Nelson ; Boillot, François ; Delaporte, Eric ; Mbala-Kingebeni, Placide ; Ayouba, Ahidjo ; Peeters, Martine ; Ahuka-Mundeke, Steve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-47d16e6024aa3eb30a1520f92862f0b95494a68cafcc54ac88841487a60645e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>Brief Report</topic><topic>Disease transmission</topic><topic>Ebola virus</topic><topic>Ebolavirus</topic><topic>Epidemics</topic><topic>Serology</topic><topic>Survivor</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nkuba-Ndaye, Antoine</creatorcontrib><creatorcontrib>Mukadi-Bamuleka, Daniel</creatorcontrib><creatorcontrib>Bulabula-Penge, Junior</creatorcontrib><creatorcontrib>Thaurignac, Guillaume</creatorcontrib><creatorcontrib>Edidi-Atani, François</creatorcontrib><creatorcontrib>Mambu-Mbika, Fabrice</creatorcontrib><creatorcontrib>Danga-Yema, Bernice</creatorcontrib><creatorcontrib>Matondo-Kuamfumu, Meris</creatorcontrib><creatorcontrib>Kinganda-Lusamaki, Eddy</creatorcontrib><creatorcontrib>Bisento, Nella</creatorcontrib><creatorcontrib>Lumembe-Numbi, Raphaël</creatorcontrib><creatorcontrib>Kabamba-Lungenyi, Gabriel</creatorcontrib><creatorcontrib>Kitsa-Mutsumbirwa, Divine</creatorcontrib><creatorcontrib>Kambale-Sivihwa, Nelson</creatorcontrib><creatorcontrib>Boillot, François</creatorcontrib><creatorcontrib>Delaporte, Eric</creatorcontrib><creatorcontrib>Mbala-Kingebeni, Placide</creatorcontrib><creatorcontrib>Ayouba, Ahidjo</creatorcontrib><creatorcontrib>Peeters, Martine</creatorcontrib><creatorcontrib>Ahuka-Mundeke, Steve</creatorcontrib><collection>Oxford Academic Journals (Open Access)</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nkuba-Ndaye, Antoine</au><au>Mukadi-Bamuleka, Daniel</au><au>Bulabula-Penge, Junior</au><au>Thaurignac, Guillaume</au><au>Edidi-Atani, François</au><au>Mambu-Mbika, Fabrice</au><au>Danga-Yema, Bernice</au><au>Matondo-Kuamfumu, Meris</au><au>Kinganda-Lusamaki, Eddy</au><au>Bisento, Nella</au><au>Lumembe-Numbi, Raphaël</au><au>Kabamba-Lungenyi, Gabriel</au><au>Kitsa-Mutsumbirwa, Divine</au><au>Kambale-Sivihwa, Nelson</au><au>Boillot, François</au><au>Delaporte, Eric</au><au>Mbala-Kingebeni, Placide</au><au>Ayouba, Ahidjo</au><au>Peeters, Martine</au><au>Ahuka-Mundeke, Steve</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context</atitle><jtitle>The Journal of infectious diseases</jtitle><date>2022-08-24</date><risdate>2022</risdate><volume>226</volume><issue>2</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.
Methods
Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.
Results
After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.
Conclusions
These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.
In clinically suspected EVD patients, EVD may be missed and inadvertently cause EBOV resurgence. Thus, surveillance during and after outbreaks should be extended to EBOV household contacts and to patients discharged as negative with an accurate serologic assay.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35176762</pmid><doi>10.1093/infdis/jiac057</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2850-7498</orcidid><orcidid>https://orcid.org/0000-0002-5081-1632</orcidid><orcidid>https://orcid.org/0000-0001-6738-8730</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2022-08, Vol.226 (2), p.352-356 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford University Press Journals; Alma/SFX Local Collection |
| subjects | Antigens Brief Report Disease transmission Ebola virus Ebolavirus Epidemics Serology Survivor Viruses |
| title | Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context |
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