ROR1-targeting switchable CAR-T cells for cancer therapy

The success of chimeric antigen receptor T cell (CAR-T) therapy in the treatment of hematologic malignancies has prompted the development of numerous CAR-T technologies, including switchable CAR-T (sCAR-T) systems that combine a universal CAR-T with bispecific adapter proteins. Owing to their contro...

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Veröffentlicht in:	Oncogene 2022-08, Vol.41 (34), p.4104-4114
Hauptverfasser:	Peng, Haiyong, Nerreter, Thomas, Mestermann, Katrin, Wachter, Jakob, Chang, Jing, Hudecek, Michael, Rader, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/31 13/44 59/5 631/61/51 631/67/1059/2325 64/60 82/103 82/16 82/29 82/80 82/83 Adapter proteins Adaptor proteins Affinity Antitumor activity Apoptosis Cancer therapies Cell Biology Cell Line, Tumor Chimeric antigen receptors Epitopes Human Genetics Humans Internal Medicine Kinases Lymphocytes T Medicine Medicine & Public Health Neoplasms - genetics Neoplasms - metabolism Neoplasms - therapy Oncology Protein-tyrosine kinase receptors Receptor Tyrosine Kinase-like Orphan Receptors - genetics Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism T-Lymphocytes - metabolism
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