A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype

Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled A 2A adenosine receptors (A 2A ARs) on the surface of neutrophils....

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