Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease

The NADPH oxidase DUOX1 contributes to epithelial production of alarmins, including interleukin (IL)-33, in response to injurious triggers such as airborne protease allergens, and mediates development of mucus metaplasia and airway remodeling in chronic allergic airways diseases. DUOX1 is also expre...

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Veröffentlicht in:	Mucosal immunology 2022-05, Vol.15 (5), p.977-989
Hauptverfasser:	Morris, Carolyn R., Habibovic, Aida, Dustin, Christopher M., Schiffers, Caspar, Lin, Miao-Chong, Ather, Jennifer L., Janssen-Heininger, Yvonne M.W., Poynter, Matthew E., Utermohlen, Olaf, Krönke, Martin, van der Vliet, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling Allergens Allergic diseases Allergology Animals Antibodies Antigens, Dermatophagoides Biomedical and Life Sciences Biomedicine Cell activation Dual Oxidases Epithelium Gastroenterology Hypersensitivity Immunology Inflammation Lung Lung diseases Macrophages Metaplasia Monocytes Mucus NAD(P)H oxidase Pyroglyphidae Respiratory tract Respiratory tract diseases
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