Natural locus coeruleus dynamics during feeding
Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was suppressed during food consumption...
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Veröffentlicht in: | Science advances 2022-08, Vol.8 (33), p.eabn9134 |
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creator | Sciolino, Natale R Hsiang, Madeline Mazzone, Christopher M Wilson, Leslie R Plummer, Nicholas W Amin, Jaisal Smith, Kathleen G McGee, Christopher A Fry, Sydney A Yang, Cindy X Powell, Jeanne M Bruchas, Michael R Kravitz, Alexxai V Cushman, Jesse D Krashes, Michael J Cui, Guohong Jensen, Patricia |
description | Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. Here, we found that LC-NE activity was suppressed during food consumption, and the magnitude of this neural response was attenuated as mice consumed more pellets throughout the session, suggesting that LC responses to food are modulated by satiety state. Visual-evoked LC-NE activity was also attenuated in sated mice, suggesting that satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by brief or longer durations of LC-NE activation. Last, we found that activation of the LC to the lateral hypothalamus pathway suppresses feeding and enhances avoidance and anxiety-like responding. Our findings suggest that LC-NE neurons modulate feeding by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g., satiety). |
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Here, we found that LC-NE activity was suppressed during food consumption, and the magnitude of this neural response was attenuated as mice consumed more pellets throughout the session, suggesting that LC responses to food are modulated by satiety state. Visual-evoked LC-NE activity was also attenuated in sated mice, suggesting that satiety state modulates LC-NE encoding of multiple behavioral states. We also found that food intake could be attenuated by brief or longer durations of LC-NE activation. Last, we found that activation of the LC to the lateral hypothalamus pathway suppresses feeding and enhances avoidance and anxiety-like responding. Our findings suggest that LC-NE neurons modulate feeding by integrating both external cues (e.g., anxiogenic environmental cues) and internal drives (e.g., satiety).</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.abn9134</identifier><identifier>PMID: 35984878</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Neuroscience ; Physiology ; SciAdv r-articles</subject><ispartof>Science advances, 2022-08, Vol.8 (33), p.eabn9134</ispartof><rights>Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). 2022 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-5fe000b39934ba27b84239299ecdd879af8b016c5a855b9b145047a4825b4b193</citedby><cites>FETCH-LOGICAL-c390t-5fe000b39934ba27b84239299ecdd879af8b016c5a855b9b145047a4825b4b193</cites><orcidid>0000-0003-2794-1989 ; 0000-0003-3188-0955 ; 0000-0003-1311-0076 ; 0000-0001-9535-7544 ; 0000-0003-4039-4908 ; 0000-0002-4555-028X ; 0000-0001-6459-7289 ; 0000-0001-5983-0218 ; 0000-0002-3494-2376 ; 0000-0003-2971-814X ; 0000-0002-2879-2017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390985/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390985/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35984878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sciolino, Natale R</creatorcontrib><creatorcontrib>Hsiang, Madeline</creatorcontrib><creatorcontrib>Mazzone, Christopher M</creatorcontrib><creatorcontrib>Wilson, Leslie R</creatorcontrib><creatorcontrib>Plummer, Nicholas W</creatorcontrib><creatorcontrib>Amin, Jaisal</creatorcontrib><creatorcontrib>Smith, Kathleen G</creatorcontrib><creatorcontrib>McGee, Christopher A</creatorcontrib><creatorcontrib>Fry, Sydney A</creatorcontrib><creatorcontrib>Yang, Cindy X</creatorcontrib><creatorcontrib>Powell, Jeanne M</creatorcontrib><creatorcontrib>Bruchas, Michael R</creatorcontrib><creatorcontrib>Kravitz, Alexxai V</creatorcontrib><creatorcontrib>Cushman, Jesse D</creatorcontrib><creatorcontrib>Krashes, Michael J</creatorcontrib><creatorcontrib>Cui, Guohong</creatorcontrib><creatorcontrib>Jensen, Patricia</creatorcontrib><title>Natural locus coeruleus dynamics during feeding</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity in natural, homeostatic feeding remains unclear. 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title | Natural locus coeruleus dynamics during feeding |
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