Recurrent pleural effusion in myeloma
ABSTRACT Plasma cell (PC) disorders make up a spectrum of diseases which include myeloma and amyloidosis. Pleural effusion in myeloma is rare and may result from myelomatous infiltration of the pleura or heart failure in cardiac amyloidosis. Benign causes of pleural effusion include infection, hypoa...
Gespeichert in:
| Veröffentlicht in: | Oxford Medical Case Reports 2022-08, Vol.2022 (8), p.318 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 318 |
| container_title | Oxford Medical Case Reports |
| container_volume | 2022 |
| creator | Woo, Wing Hang Ithnin, Azlin Raffali, Mohd Asyiq Al-Fard Mohd Abd. Hamid, Mohamed Faisal Abdul Wahid, S Fadilah Wan Jamaludin, Wan Fariza |
| description | ABSTRACT
Plasma cell (PC) disorders make up a spectrum of diseases which include myeloma and amyloidosis. Pleural effusion in myeloma is rare and may result from myelomatous infiltration of the pleura or heart failure in cardiac amyloidosis. Benign causes of pleural effusion include infection, hypoalbuminemia or chronic renal impairment. Myelomatous pleural effusion (MPE) is diagnosed via pleural fluid cytomorphology and flow cytometry for malignant PCs, protein electrophoresis or pleural biopsy. A 74-year-old man with immunoglobulin A myeloma developed recurrent MPE with possible secondary cardiac amyloidosis. Despite achieving partial remission in serum paraprotein, the effusion was refractory to percutaneous drainage and pleurodesis. The treatment is aimed at eradicating myeloma and relieving respiratory symptoms. Early recognition of myeloma progression into extramedullary infiltration and secondary amyloidosis is important. While chemotherapy intensification in older patients can be challenging, multidisciplinary management is essential in alleviating symptoms and in improving the quality of life. |
| doi_str_mv | 10.1093/omcr/omac091 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9389560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A776925361</galeid><oup_id>10.1093/omcr/omac091</oup_id><sourcerecordid>A776925361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-a5a30c663519e95111cd19646513a0cc123529755f45bfaeb2c6ce2adfb94bdd3</originalsourceid><addsrcrecordid>eNpVkE1rwzAMhs1grKXrbT8gl7FTOsuu3PgyKGVfUBiM7WwcR-48kjgkzaD_fi4tgyGQQB-PXl7GboAvgGt5HxvXp2Qd13DBpoKjzIsCccLmw_DNOQepQBbFFZtI1BqQiym7fSc39j21-6yraextnZH34xBim4U2aw5UJ-Q1u_S2Hmh-rjP2-fT4sXnJt2_Pr5v1NncSxT63aCV3SkkETRoBwFWg1VIhSMudA5HW9ArRL7H0lkrhlCNhK1_qZVlVcsYeTtxuLBuqXJKVFJmuD43tDybaYP5P2vBldvHHaFloVDwBFifAztZkQutjWnMpKmqCiy35kPrr1UppgUc7ZuzudBDH7u8PcHN01BwdNWdH5S83w2t0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Recurrent pleural effusion in myeloma</title><source>Oxford Journals Open Access Collection</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Woo, Wing Hang ; Ithnin, Azlin ; Raffali, Mohd Asyiq Al-Fard Mohd ; Abd. Hamid, Mohamed Faisal ; Abdul Wahid, S Fadilah ; Wan Jamaludin, Wan Fariza</creator><creatorcontrib>Woo, Wing Hang ; Ithnin, Azlin ; Raffali, Mohd Asyiq Al-Fard Mohd ; Abd. Hamid, Mohamed Faisal ; Abdul Wahid, S Fadilah ; Wan Jamaludin, Wan Fariza</creatorcontrib><description>ABSTRACT
Plasma cell (PC) disorders make up a spectrum of diseases which include myeloma and amyloidosis. Pleural effusion in myeloma is rare and may result from myelomatous infiltration of the pleura or heart failure in cardiac amyloidosis. Benign causes of pleural effusion include infection, hypoalbuminemia or chronic renal impairment. Myelomatous pleural effusion (MPE) is diagnosed via pleural fluid cytomorphology and flow cytometry for malignant PCs, protein electrophoresis or pleural biopsy. A 74-year-old man with immunoglobulin A myeloma developed recurrent MPE with possible secondary cardiac amyloidosis. Despite achieving partial remission in serum paraprotein, the effusion was refractory to percutaneous drainage and pleurodesis. The treatment is aimed at eradicating myeloma and relieving respiratory symptoms. Early recognition of myeloma progression into extramedullary infiltration and secondary amyloidosis is important. While chemotherapy intensification in older patients can be challenging, multidisciplinary management is essential in alleviating symptoms and in improving the quality of life.</description><identifier>EISSN: 2053-8855</identifier><identifier>DOI: 10.1093/omcr/omac091</identifier><identifier>PMID: 35991502</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Amyloidosis ; Cancer ; Case Report ; Chemotherapy ; Diseases ; Health aspects ; Immunoglobulin A ; Pleural effusions ; Relapse</subject><ispartof>Oxford Medical Case Reports, 2022-08, Vol.2022 (8), p.318</ispartof><rights>The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2022</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-a5a30c663519e95111cd19646513a0cc123529755f45bfaeb2c6ce2adfb94bdd3</citedby><orcidid>0000-0002-3692-2344</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389560/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389560/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Woo, Wing Hang</creatorcontrib><creatorcontrib>Ithnin, Azlin</creatorcontrib><creatorcontrib>Raffali, Mohd Asyiq Al-Fard Mohd</creatorcontrib><creatorcontrib>Abd. Hamid, Mohamed Faisal</creatorcontrib><creatorcontrib>Abdul Wahid, S Fadilah</creatorcontrib><creatorcontrib>Wan Jamaludin, Wan Fariza</creatorcontrib><title>Recurrent pleural effusion in myeloma</title><title>Oxford Medical Case Reports</title><description>ABSTRACT
Plasma cell (PC) disorders make up a spectrum of diseases which include myeloma and amyloidosis. Pleural effusion in myeloma is rare and may result from myelomatous infiltration of the pleura or heart failure in cardiac amyloidosis. Benign causes of pleural effusion include infection, hypoalbuminemia or chronic renal impairment. Myelomatous pleural effusion (MPE) is diagnosed via pleural fluid cytomorphology and flow cytometry for malignant PCs, protein electrophoresis or pleural biopsy. A 74-year-old man with immunoglobulin A myeloma developed recurrent MPE with possible secondary cardiac amyloidosis. Despite achieving partial remission in serum paraprotein, the effusion was refractory to percutaneous drainage and pleurodesis. The treatment is aimed at eradicating myeloma and relieving respiratory symptoms. Early recognition of myeloma progression into extramedullary infiltration and secondary amyloidosis is important. While chemotherapy intensification in older patients can be challenging, multidisciplinary management is essential in alleviating symptoms and in improving the quality of life.</description><subject>Amyloidosis</subject><subject>Cancer</subject><subject>Case Report</subject><subject>Chemotherapy</subject><subject>Diseases</subject><subject>Health aspects</subject><subject>Immunoglobulin A</subject><subject>Pleural effusions</subject><subject>Relapse</subject><issn>2053-8855</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNpVkE1rwzAMhs1grKXrbT8gl7FTOsuu3PgyKGVfUBiM7WwcR-48kjgkzaD_fi4tgyGQQB-PXl7GboAvgGt5HxvXp2Qd13DBpoKjzIsCccLmw_DNOQepQBbFFZtI1BqQiym7fSc39j21-6yraextnZH34xBim4U2aw5UJ-Q1u_S2Hmh-rjP2-fT4sXnJt2_Pr5v1NncSxT63aCV3SkkETRoBwFWg1VIhSMudA5HW9ArRL7H0lkrhlCNhK1_qZVlVcsYeTtxuLBuqXJKVFJmuD43tDybaYP5P2vBldvHHaFloVDwBFifAztZkQutjWnMpKmqCiy35kPrr1UppgUc7ZuzudBDH7u8PcHN01BwdNWdH5S83w2t0</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Woo, Wing Hang</creator><creator>Ithnin, Azlin</creator><creator>Raffali, Mohd Asyiq Al-Fard Mohd</creator><creator>Abd. Hamid, Mohamed Faisal</creator><creator>Abdul Wahid, S Fadilah</creator><creator>Wan Jamaludin, Wan Fariza</creator><general>Oxford University Press</general><scope>TOX</scope><scope>IAO</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3692-2344</orcidid></search><sort><creationdate>20220801</creationdate><title>Recurrent pleural effusion in myeloma</title><author>Woo, Wing Hang ; Ithnin, Azlin ; Raffali, Mohd Asyiq Al-Fard Mohd ; Abd. Hamid, Mohamed Faisal ; Abdul Wahid, S Fadilah ; Wan Jamaludin, Wan Fariza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-a5a30c663519e95111cd19646513a0cc123529755f45bfaeb2c6ce2adfb94bdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amyloidosis</topic><topic>Cancer</topic><topic>Case Report</topic><topic>Chemotherapy</topic><topic>Diseases</topic><topic>Health aspects</topic><topic>Immunoglobulin A</topic><topic>Pleural effusions</topic><topic>Relapse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woo, Wing Hang</creatorcontrib><creatorcontrib>Ithnin, Azlin</creatorcontrib><creatorcontrib>Raffali, Mohd Asyiq Al-Fard Mohd</creatorcontrib><creatorcontrib>Abd. Hamid, Mohamed Faisal</creatorcontrib><creatorcontrib>Abdul Wahid, S Fadilah</creatorcontrib><creatorcontrib>Wan Jamaludin, Wan Fariza</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Gale Academic OneFile</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxford Medical Case Reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woo, Wing Hang</au><au>Ithnin, Azlin</au><au>Raffali, Mohd Asyiq Al-Fard Mohd</au><au>Abd. Hamid, Mohamed Faisal</au><au>Abdul Wahid, S Fadilah</au><au>Wan Jamaludin, Wan Fariza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent pleural effusion in myeloma</atitle><jtitle>Oxford Medical Case Reports</jtitle><date>2022-08-01</date><risdate>2022</risdate><volume>2022</volume><issue>8</issue><spage>318</spage><pages>318-</pages><eissn>2053-8855</eissn><abstract>ABSTRACT
Plasma cell (PC) disorders make up a spectrum of diseases which include myeloma and amyloidosis. Pleural effusion in myeloma is rare and may result from myelomatous infiltration of the pleura or heart failure in cardiac amyloidosis. Benign causes of pleural effusion include infection, hypoalbuminemia or chronic renal impairment. Myelomatous pleural effusion (MPE) is diagnosed via pleural fluid cytomorphology and flow cytometry for malignant PCs, protein electrophoresis or pleural biopsy. A 74-year-old man with immunoglobulin A myeloma developed recurrent MPE with possible secondary cardiac amyloidosis. Despite achieving partial remission in serum paraprotein, the effusion was refractory to percutaneous drainage and pleurodesis. The treatment is aimed at eradicating myeloma and relieving respiratory symptoms. Early recognition of myeloma progression into extramedullary infiltration and secondary amyloidosis is important. While chemotherapy intensification in older patients can be challenging, multidisciplinary management is essential in alleviating symptoms and in improving the quality of life.</abstract><pub>Oxford University Press</pub><pmid>35991502</pmid><doi>10.1093/omcr/omac091</doi><orcidid>https://orcid.org/0000-0002-3692-2344</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2053-8855 |
| ispartof | Oxford Medical Case Reports, 2022-08, Vol.2022 (8), p.318 |
| issn | 2053-8855 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9389560 |
| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amyloidosis Cancer Case Report Chemotherapy Diseases Health aspects Immunoglobulin A Pleural effusions Relapse |
| title | Recurrent pleural effusion in myeloma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T00%3A49%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recurrent%20pleural%20effusion%20in%20myeloma&rft.jtitle=Oxford%20Medical%20Case%20Reports&rft.au=Woo,%20Wing%20Hang&rft.date=2022-08-01&rft.volume=2022&rft.issue=8&rft.spage=318&rft.pages=318-&rft.eissn=2053-8855&rft_id=info:doi/10.1093/omcr/omac091&rft_dat=%3Cgale_pubme%3EA776925361%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/35991502&rft_galeid=A776925361&rft_oup_id=10.1093/omcr/omac091&rfr_iscdi=true |