A highly efficacious live attenuated mumps virus—based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike

With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella) vaccine has been one of the safest and most effective human vaccines used in infants and children since the 1960s. Here, we developed live att...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-08, Vol.119 (33), p.1-12
Hauptverfasser:	Zhang, Yuexiu, Lu, Mijia, Mahesh, K C, Kim, Eunsoo, Shamseldin, Mohamed M., Ye, Chengjin, Dravid, Piyush, Chamblee, Michelle, Park, Jun-Gyu, Hall, Jesse M., Trivedi, Sheetal, Chaiwatpongsakorn, Supranee, Kenny, Adam D., Murthy, Satyapramod Srinivasa, Sharma, Himanshu, Liang, Xueya, Yount, Jacob S., Kapoor, Amit, Martinez-Sobrido, Luis, Dubey, Purnima, Boyaka, Prosper N., Peeples, Mark E., Li, Jianrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Biological Sciences COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - genetics COVID-19 Vaccines - immunology Genomes Hamsters Immune response (cell-mediated) Immunization Immunogenicity Immunogenicity, Vaccine Immunoglobulin A Lymphocytes Lymphocytes T M gene Measles-Mumps-Rubella Vaccine - genetics Measles-Mumps-Rubella Vaccine - immunology Mesocricetus Mice Mucosal immunity Mumps Mumps virus - genetics Mumps virus - immunology Neutralizing Proline - genetics Public health Rubella SARS-CoV-2 - genetics SARS-CoV-2 - immunology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike protein Vaccine Efficacy Vaccines Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Viruses
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