The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports
Alien limb phenomenon (ALP) is a clinical finding seen in numerous neurological disorders, including Creutzfeldt-Jakob disease (CJD). We aimed to conduct a systematic review to update advances in understanding the classification and pathophysiology of ALP in CJD. We used PubMed advanced-strategy sea...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-07, Vol.14 (7), p.e27029-e27029 |
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| creator | Sen, Meghdeep Moncayo, Juan A Kelley, Maria A Suarez Salazar, Deydie Tenemaza, Maria Gabriela Camacho, Mikaela Hassen, Gashaw Lopez, Guillermo E Monteros, Gustavo Garofalo, Gabriela Yadav, Ayush Ortiz, Juan Fernando |
| description | Alien limb phenomenon (ALP) is a clinical finding seen in numerous neurological disorders, including Creutzfeldt-Jakob disease (CJD). We aimed to conduct a systematic review to update advances in understanding the classification and pathophysiology of ALP in CJD. We used PubMed advanced-strategy searches and only included full-text observational studies and case reports conducted on humans and written in English. We used the PRISMA protocol for this systematic review and the Methodological Quality of Case Reports tool to assess the bias encountered in each study. After applying the inclusion/exclusion criteria, 10 case reports were reviewed. Two independent reviewers analyzed data and confirmed the phenotype of each case of the alien limb in CJD separately. Overall, the most prevalent ALP phenotype presenting in patients with CJD was the posterior phenotype, usually in the early stages of the disease. Our findings corroborate previous research in demonstrating the pathophysiology behind ALP in CJD. We suggest physicians suspect CJD whenever patients present with ALP as the initial symptom. |
| doi_str_mv | 10.7759/cureus.27029 |
| format | Article |
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We aimed to conduct a systematic review to update advances in understanding the classification and pathophysiology of ALP in CJD. We used PubMed advanced-strategy searches and only included full-text observational studies and case reports conducted on humans and written in English. We used the PRISMA protocol for this systematic review and the Methodological Quality of Case Reports tool to assess the bias encountered in each study. After applying the inclusion/exclusion criteria, 10 case reports were reviewed. Two independent reviewers analyzed data and confirmed the phenotype of each case of the alien limb in CJD separately. Overall, the most prevalent ALP phenotype presenting in patients with CJD was the posterior phenotype, usually in the early stages of the disease. Our findings corroborate previous research in demonstrating the pathophysiology behind ALP in CJD. We suggest physicians suspect CJD whenever patients present with ALP as the initial symptom.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.27029</identifier><identifier>PMID: 35989745</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Alzheimer's disease ; Apraxia ; Ataxia ; Bias ; Brain ; Case reports ; Creutzfeldt-Jakob disease ; Dementia ; Electroencephalography ; Gait ; Genotype & phenotype ; Magnetic resonance imaging ; Neurology ; Neuropathology ; Pathophysiology ; Stroke ; Systematic review</subject><ispartof>Curēus (Palo Alto, CA), 2022-07, Vol.14 (7), p.e27029-e27029</ispartof><rights>Copyright © 2022, Sen et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Sen et al. 2022 Sen et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-bddb7b70109509200086f50338e2d192bf48b9cd401d771fb6f0f70c2b2ea87e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388051/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388051/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids></links><search><creatorcontrib>Sen, Meghdeep</creatorcontrib><creatorcontrib>Moncayo, Juan A</creatorcontrib><creatorcontrib>Kelley, Maria A</creatorcontrib><creatorcontrib>Suarez Salazar, Deydie</creatorcontrib><creatorcontrib>Tenemaza, Maria Gabriela</creatorcontrib><creatorcontrib>Camacho, Mikaela</creatorcontrib><creatorcontrib>Hassen, Gashaw</creatorcontrib><creatorcontrib>Lopez, Guillermo E</creatorcontrib><creatorcontrib>Monteros, Gustavo</creatorcontrib><creatorcontrib>Garofalo, Gabriela</creatorcontrib><creatorcontrib>Yadav, Ayush</creatorcontrib><creatorcontrib>Ortiz, Juan Fernando</creatorcontrib><title>The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports</title><title>Curēus (Palo Alto, CA)</title><description>Alien limb phenomenon (ALP) is a clinical finding seen in numerous neurological disorders, including Creutzfeldt-Jakob disease (CJD). 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We suggest physicians suspect CJD whenever patients present with ALP as the initial symptom.</description><subject>Alzheimer's disease</subject><subject>Apraxia</subject><subject>Ataxia</subject><subject>Bias</subject><subject>Brain</subject><subject>Case reports</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Dementia</subject><subject>Electroencephalography</subject><subject>Gait</subject><subject>Genotype & phenotype</subject><subject>Magnetic resonance imaging</subject><subject>Neurology</subject><subject>Neuropathology</subject><subject>Pathophysiology</subject><subject>Stroke</subject><subject>Systematic review</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtPGzEUhS1URBCw4wdYYsOiE2zPwzaLSlFaXopE1aarLix75poYZsapPZMKfn0NQYiysK6t--nc43sQOqZkynkpz-oxwBinjBMmd9A-o5XIBBXFp3f3CTqK8Z4QQglnhJM9NMlLKSQvyn30e7kCPGsd9HjhOoO_r6D3XTo9dj2eJ_XhyULbDNmNfvAGf3URdIRzPMM_H-MAnR5cjX_AxsFf7C2ep2Z6rn0Y4iHatbqNcPRaD9Cvi2_L-VW2uL28ns8WWc14NWSmaQw3PNmTJZEsGRWVLUmeC2ANlczYQhhZNwWhDefUmsoSy0nNDAMtOOQH6MtWdz2aDpoa-iHoVq2D63R4VF479X-ndyt15zdK5kKQkiaB01eB4P-MEAfVuVhD2-oe_BhVWm-ZphekSujJB_Tej6FP33umRFXyosgT9XlL1cHHGMC-maFEPQentsGpl-Dyf2Aziqg</recordid><startdate>20220719</startdate><enddate>20220719</enddate><creator>Sen, Meghdeep</creator><creator>Moncayo, Juan A</creator><creator>Kelley, Maria A</creator><creator>Suarez Salazar, Deydie</creator><creator>Tenemaza, Maria Gabriela</creator><creator>Camacho, Mikaela</creator><creator>Hassen, Gashaw</creator><creator>Lopez, Guillermo E</creator><creator>Monteros, Gustavo</creator><creator>Garofalo, Gabriela</creator><creator>Yadav, Ayush</creator><creator>Ortiz, Juan Fernando</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220719</creationdate><title>The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports</title><author>Sen, Meghdeep ; Moncayo, Juan A ; Kelley, Maria A ; Suarez Salazar, Deydie ; Tenemaza, Maria Gabriela ; Camacho, Mikaela ; Hassen, Gashaw ; Lopez, Guillermo E ; Monteros, Gustavo ; Garofalo, Gabriela ; Yadav, Ayush ; Ortiz, Juan Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-bddb7b70109509200086f50338e2d192bf48b9cd401d771fb6f0f70c2b2ea87e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Apraxia</topic><topic>Ataxia</topic><topic>Bias</topic><topic>Brain</topic><topic>Case reports</topic><topic>Creutzfeldt-Jakob disease</topic><topic>Dementia</topic><topic>Electroencephalography</topic><topic>Gait</topic><topic>Genotype & phenotype</topic><topic>Magnetic resonance imaging</topic><topic>Neurology</topic><topic>Neuropathology</topic><topic>Pathophysiology</topic><topic>Stroke</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sen, Meghdeep</creatorcontrib><creatorcontrib>Moncayo, Juan A</creatorcontrib><creatorcontrib>Kelley, Maria A</creatorcontrib><creatorcontrib>Suarez Salazar, Deydie</creatorcontrib><creatorcontrib>Tenemaza, Maria Gabriela</creatorcontrib><creatorcontrib>Camacho, Mikaela</creatorcontrib><creatorcontrib>Hassen, Gashaw</creatorcontrib><creatorcontrib>Lopez, Guillermo E</creatorcontrib><creatorcontrib>Monteros, Gustavo</creatorcontrib><creatorcontrib>Garofalo, Gabriela</creatorcontrib><creatorcontrib>Yadav, Ayush</creatorcontrib><creatorcontrib>Ortiz, Juan Fernando</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sen, Meghdeep</au><au>Moncayo, Juan A</au><au>Kelley, Maria A</au><au>Suarez Salazar, Deydie</au><au>Tenemaza, Maria Gabriela</au><au>Camacho, Mikaela</au><au>Hassen, Gashaw</au><au>Lopez, Guillermo E</au><au>Monteros, Gustavo</au><au>Garofalo, Gabriela</au><au>Yadav, Ayush</au><au>Ortiz, Juan Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2022-07-19</date><risdate>2022</risdate><volume>14</volume><issue>7</issue><spage>e27029</spage><epage>e27029</epage><pages>e27029-e27029</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Alien limb phenomenon (ALP) is a clinical finding seen in numerous neurological disorders, including Creutzfeldt-Jakob disease (CJD). 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| subjects | Alzheimer's disease Apraxia Ataxia Bias Brain Case reports Creutzfeldt-Jakob disease Dementia Electroencephalography Gait Genotype & phenotype Magnetic resonance imaging Neurology Neuropathology Pathophysiology Stroke Systematic review |
| title | The Alien Limb Phenomenon in Creutzfeldt-Jakob Disease: A Systematic Review of Case Reports |
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