Characterization of Aldosterone-producing Cell Cluster (APCC) at Single-cell Resolution

Context: The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone synthase (CYP11B2) are frequently found in adult adrenals and harbor somatic mutations that are also detected in aldosterone...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2022-09, Vol.107 (9), p.2439-2448
Hauptverfasser:	Iwahashi, Norifusa, Umakoshi, Hironobu, Seki, Tsugio, E. Gomez-Sanchez, Celso, Mukai, Kuniaki, Suematsu, Makoto, Umezawa, Yuta, Oya, Mototsugu, Kosaka, Takeo, Seki, Masahide, Suzuki, Yutaka, Horiuchi, Yutaka, Ogawa, Yoshihiro, Nishimoto, Koshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone Clinical Corticosteroids Gene expression Genes Hydroxylases RNA RNA sequencing
Online-Zugang:	Volltext
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