Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination
Abstract Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no c...
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| Veröffentlicht in: | Laboratory medicine 2022-09, Vol.53 (5), p.540-541 |
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| creator | Higuchi, Takakazu Hoshi, Takao Nakajima, Astuko Haruki, Kosuke |
| description | Abstract
Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no clinical relevance, it can lead to unnecessary fear, diagnostic errors, or unnecessary tests and interventions when unrecognized.
Pseudothrombocytopenia was detected in a 25-year-old woman 8 months after the second dose of mRNA COVID-19 vaccine, BNT162b2. The pseudothrombocytopenia was transient and the duration was shorter than 3 months. As pseudothromobocytopenia is not detected unless blood is drawn for other objectives, it is difficult to determine its true occurrence among recipients of vaccines. This case shows that pseudothrombocytopenia may develop transiently even months after COVID-19 vaccination and should be considered when thrombocytopenia is found in recipients of the vaccine to avoid unnecessary fear, diagnostic errors, or unnecessary tests and interventions. |
| doi_str_mv | 10.1093/labmed/lmac031 |
| format | Article |
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Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no clinical relevance, it can lead to unnecessary fear, diagnostic errors, or unnecessary tests and interventions when unrecognized.
Pseudothrombocytopenia was detected in a 25-year-old woman 8 months after the second dose of mRNA COVID-19 vaccine, BNT162b2. The pseudothrombocytopenia was transient and the duration was shorter than 3 months. As pseudothromobocytopenia is not detected unless blood is drawn for other objectives, it is difficult to determine its true occurrence among recipients of vaccines. This case shows that pseudothrombocytopenia may develop transiently even months after COVID-19 vaccination and should be considered when thrombocytopenia is found in recipients of the vaccine to avoid unnecessary fear, diagnostic errors, or unnecessary tests and interventions.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmac031</identifier><identifier>PMID: 35640881</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Antibodies ; Anticoagulants ; Anticoagulants (Medicine) ; Antigens ; Blood platelets ; Case Study ; Coronaviruses ; COVID-19 vaccines ; Ethylenediaminetetraacetic acid ; Immunization ; Medical errors ; Patients ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; Thrombocytopenia ; Vaccination</subject><ispartof>Laboratory medicine, 2022-09, Vol.53 (5), p.540-541</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-937c30abdd1c646f0394674cadb1c37b3da45529b87112d86905bb613f5f4e8f3</citedby><cites>FETCH-LOGICAL-c479t-937c30abdd1c646f0394674cadb1c37b3da45529b87112d86905bb613f5f4e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35640881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higuchi, Takakazu</creatorcontrib><creatorcontrib>Hoshi, Takao</creatorcontrib><creatorcontrib>Nakajima, Astuko</creatorcontrib><creatorcontrib>Haruki, Kosuke</creatorcontrib><title>Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Abstract
Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no clinical relevance, it can lead to unnecessary fear, diagnostic errors, or unnecessary tests and interventions when unrecognized.
Pseudothrombocytopenia was detected in a 25-year-old woman 8 months after the second dose of mRNA COVID-19 vaccine, BNT162b2. The pseudothrombocytopenia was transient and the duration was shorter than 3 months. As pseudothromobocytopenia is not detected unless blood is drawn for other objectives, it is difficult to determine its true occurrence among recipients of vaccines. This case shows that pseudothrombocytopenia may develop transiently even months after COVID-19 vaccination and should be considered when thrombocytopenia is found in recipients of the vaccine to avoid unnecessary fear, diagnostic errors, or unnecessary tests and interventions.</description><subject>Antibodies</subject><subject>Anticoagulants</subject><subject>Anticoagulants (Medicine)</subject><subject>Antigens</subject><subject>Blood platelets</subject><subject>Case Study</subject><subject>Coronaviruses</subject><subject>COVID-19 vaccines</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Immunization</subject><subject>Medical errors</subject><subject>Patients</subject><subject>RNA</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Thrombocytopenia</subject><subject>Vaccination</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFks1vFCEYxonR2LV69Wgm8dIepuVr-LiYbLZVm7Sph9orYYDp0szACoxJ_3tZd60faWI4EOD3Pi8PPAC8RfAEQUlOR91Pzp6OkzaQoGdggSQlLecEPgcLCCFvO4j5AXiV831dUsnwS3BAOkahEGgBrm6SDtm7UJov2c02lnWKUx_NQ4kbF7xuzlxxpjjbiOYqhrLOzXIoLjWr69uLsxbJ5lYb44MuPobX4MWgx-ze7OdD8PXj-c3qc3t5_elitbxsDeWytJJwQ6DurUWGUTZAIinj1GjbI0N4T6ymXYdlLzhC2AomYdf3DJGhG6gTAzkEH3a6m3lr39TrJz2qTfKTTg8qaq_-Pgl-re7idyWJoKjjVeBoL5Dit9nloiafjRtHHVycs8KMY4Kx5LSi7_9B7-OcQrWnMEeYMMYg-k3d6dEpH4ZY-5qtqFpyLhAk4mfbkyeoOqybvInBDb7uP1VgUsw5ueHRI4JqGwC1C4DaB6AWvPvzZR7xXz9egeMdEOfN_8R-ACEPulI</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Higuchi, Takakazu</creator><creator>Hoshi, Takao</creator><creator>Nakajima, Astuko</creator><creator>Haruki, Kosuke</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220901</creationdate><title>Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination</title><author>Higuchi, Takakazu ; Hoshi, Takao ; Nakajima, Astuko ; Haruki, Kosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-937c30abdd1c646f0394674cadb1c37b3da45529b87112d86905bb613f5f4e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Anticoagulants</topic><topic>Anticoagulants (Medicine)</topic><topic>Antigens</topic><topic>Blood platelets</topic><topic>Case Study</topic><topic>Coronaviruses</topic><topic>COVID-19 vaccines</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Immunization</topic><topic>Medical errors</topic><topic>Patients</topic><topic>RNA</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Thrombocytopenia</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Higuchi, Takakazu</creatorcontrib><creatorcontrib>Hoshi, Takao</creatorcontrib><creatorcontrib>Nakajima, Astuko</creatorcontrib><creatorcontrib>Haruki, Kosuke</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Higuchi, Takakazu</au><au>Hoshi, Takao</au><au>Nakajima, Astuko</au><au>Haruki, Kosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>53</volume><issue>5</issue><spage>540</spage><epage>541</epage><pages>540-541</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Abstract
Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no clinical relevance, it can lead to unnecessary fear, diagnostic errors, or unnecessary tests and interventions when unrecognized.
Pseudothrombocytopenia was detected in a 25-year-old woman 8 months after the second dose of mRNA COVID-19 vaccine, BNT162b2. The pseudothrombocytopenia was transient and the duration was shorter than 3 months. As pseudothromobocytopenia is not detected unless blood is drawn for other objectives, it is difficult to determine its true occurrence among recipients of vaccines. This case shows that pseudothrombocytopenia may develop transiently even months after COVID-19 vaccination and should be considered when thrombocytopenia is found in recipients of the vaccine to avoid unnecessary fear, diagnostic errors, or unnecessary tests and interventions.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35640881</pmid><doi>10.1093/labmed/lmac031</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibodies Anticoagulants Anticoagulants (Medicine) Antigens Blood platelets Case Study Coronaviruses COVID-19 vaccines Ethylenediaminetetraacetic acid Immunization Medical errors Patients RNA Severe acute respiratory syndrome coronavirus 2 Thrombocytopenia Vaccination |
| title | Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination |
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