MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia
Abstract BACKGROUND AND AIMS The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection. METHOD A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who pr...
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| description | Abstract
BACKGROUND AND AIMS
The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.
METHOD
A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who presented with ARF. They correspond to the period from March to May 2020 (G1) and from August to December 2020 (G2). We compare populations, outcomes and treatments.
RESULTS
A total of 73 patients in the first wave (G1), with a cumulative incidence (CI) of 28.3% (G1), compared with 58 patients in the second wave (G2), with a CI of 8% (G2). The mean age was higher in G2 [65.8 ± 15 years (G1); 75.3 ± 14 (G2); P |
| doi_str_mv | 10.1093/ndt/gfac068.001 |
| format | Article |
| fullrecord | <record><control><sourceid>oup_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9383839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfac068.001</oup_id><sourcerecordid>10.1093/ndt/gfac068.001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1711-2cc09bb203e50ac02729a721ac1d27b3578df12a306c4709555d418b2547a6053</originalsourceid><addsrcrecordid>eNqFkUFrGzEUhEVpoW7ac686FzaWtJa16qFg3LoJcXGI0-Yo3kpaW2UtLZLWkH-SnxsZh0JO5R3m8GYGhg-hz5RcUiLrqTd5uutAk3lzSQh9gyZ0NicVqxv-Fk2Kg1aEE_kefUjpLyFEMiEm6OnXhkn6FS_DYYDoUvA4dHihx2zxjTPePuIVuH6MFjuPbyE763PCDy7v8XZxt62Wmz8Vw9e-szq7kv4-Rud3OO8tXrmYMgZv8NbqUOQBjjadegDf71001doebY-vQhpchv70WXgD_ZgcfETvOuiT_fSiF-j36sf98qpab35eLxfrSlNBacW0JrJtGaktJ2U8E0yCYBQ0NUy0NReN6SiDmsz1TBDJOTcz2rSMzwTMCa8v0Ldz7zC2B2t0mRehV0N0B4iPKoBTrz_e7dUuHJWsm3KyFEzPBTqGlKLt_mUpUScyqpBRL2RUIVMSX86JMA7_NT8D3JCRAg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Cintra, Melissa ; Burgos Martin, Javier ; Almenara Tejederas, Marina ; Valverde Ortiz, Rocío ; Galván Toribio, Raquel ; Salguiera Lazo, Mercedes</creator><creatorcontrib>Cintra, Melissa ; Burgos Martin, Javier ; Almenara Tejederas, Marina ; Valverde Ortiz, Rocío ; Galván Toribio, Raquel ; Salguiera Lazo, Mercedes</creatorcontrib><description>Abstract
BACKGROUND AND AIMS
The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.
METHOD
A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who presented with ARF. They correspond to the period from March to May 2020 (G1) and from August to December 2020 (G2). We compare populations, outcomes and treatments.
RESULTS
A total of 73 patients in the first wave (G1), with a cumulative incidence (CI) of 28.3% (G1), compared with 58 patients in the second wave (G2), with a CI of 8% (G2). The mean age was higher in G2 [65.8 ± 15 years (G1); 75.3 ± 14 (G2); P <.05], with no difference regarding sex [63% (G1); 54% (G2)]. In G2, there was a higher proportion of patients with cardiovascular disease [23% (G1); 57% (G2)], hypertension [56% (G1); 83% (G2)]. The baseline glomerular filtration rate (GFR) being similar for both groups (CKD EPI: 69 mL/min/1.73² (G1); P = .27). In the first wave, the mean days from admission to ARF was 3.1 days ± 4.2, and 42% of the patients were diagnosed at admission (31 patients). In the second, it was 2.9 days ± 5.7, of which 60% at admission (35 patients). The most prevalent cause was prerenal in both. Higher proportion in G1 of KDIGO stage 3 (G1: 30% versus G2: 17%) and renal replacement therapy (RRT) (G1: 9 versusG2: 2 patients). Only 3 patients remained in RRT in G1 and 1 patient in G2. In G1, 64% recovered their GFR [mean time (MT): 7.5 ± 8 days], and the percentage of deaths was 34%. In G2, 72% recovered GFR (MT: 16 ± 25 days), and 19% of patients died.
CONCLUSION
Despite a lower age and comorbidity of the first wave patients, the severity and lethality was higher. There were no differences in the proportion of patients who recovered their baseline renal function, although the recovery time was longer in the second wave.
Table 1.
Characteristics of kidney failure and treatments
Group 1
Group 2
Baseline CKD
G1-2
40 (61%)
36 (63%)
P = .245
G3
16 (26%)
18 (32%)
G4-5
9 (14%)
3 (5%)
ARF severity (KDIGO)
KDIGO 1 and 2
51 (70%)
48 (83%)
P = 0.08
KDIGO 3
22 (30%)
10 (17%)
Cause of ARF
Prerenal
38 (52%)
39 (67%)
P = 0.121
Sepsis
25 (25%)
11 (19%)
Obstructive
2 (3%)
4 (7%)
Others
8 (11%)
4 (7%)
Haematuria
8 (11%)
16 (27%)
P = 0.74
ICU
18 (25%)
3 (5%)
P = 0.03
OTI
16 (22%)
3 (5%)
P = 0.007
RRT
9 (12%)
2 (3%)
P = 0.069
ARF recovery time
7.5 ± 8
16 ± 25
P = 0.04
Total Patients
73
58
Group 1: ARF patients on first wave of SARS CoV2. Group 2: ARF patients on the second wave of SARS CoV2. Baseline CKD, baseline chronic kidney disease; ICU, intensive care unit; OTI, orotracheal intubation; and RRT, renal replacement therapy. ARF recovery time: days from renal failure to recovery of baseline renal function.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfac068.001</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>AKI. Clinical. Epidemiology and Outcome</subject><ispartof>Nephrology, dialysis, transplantation, 2022-05, Vol.37 (Supplement_3)</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Cintra, Melissa</creatorcontrib><creatorcontrib>Burgos Martin, Javier</creatorcontrib><creatorcontrib>Almenara Tejederas, Marina</creatorcontrib><creatorcontrib>Valverde Ortiz, Rocío</creatorcontrib><creatorcontrib>Galván Toribio, Raquel</creatorcontrib><creatorcontrib>Salguiera Lazo, Mercedes</creatorcontrib><title>MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia</title><title>Nephrology, dialysis, transplantation</title><description>Abstract
BACKGROUND AND AIMS
The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.
METHOD
A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who presented with ARF. They correspond to the period from March to May 2020 (G1) and from August to December 2020 (G2). We compare populations, outcomes and treatments.
RESULTS
A total of 73 patients in the first wave (G1), with a cumulative incidence (CI) of 28.3% (G1), compared with 58 patients in the second wave (G2), with a CI of 8% (G2). The mean age was higher in G2 [65.8 ± 15 years (G1); 75.3 ± 14 (G2); P <.05], with no difference regarding sex [63% (G1); 54% (G2)]. In G2, there was a higher proportion of patients with cardiovascular disease [23% (G1); 57% (G2)], hypertension [56% (G1); 83% (G2)]. The baseline glomerular filtration rate (GFR) being similar for both groups (CKD EPI: 69 mL/min/1.73² (G1); P = .27). In the first wave, the mean days from admission to ARF was 3.1 days ± 4.2, and 42% of the patients were diagnosed at admission (31 patients). In the second, it was 2.9 days ± 5.7, of which 60% at admission (35 patients). The most prevalent cause was prerenal in both. Higher proportion in G1 of KDIGO stage 3 (G1: 30% versus G2: 17%) and renal replacement therapy (RRT) (G1: 9 versusG2: 2 patients). Only 3 patients remained in RRT in G1 and 1 patient in G2. In G1, 64% recovered their GFR [mean time (MT): 7.5 ± 8 days], and the percentage of deaths was 34%. In G2, 72% recovered GFR (MT: 16 ± 25 days), and 19% of patients died.
CONCLUSION
Despite a lower age and comorbidity of the first wave patients, the severity and lethality was higher. There were no differences in the proportion of patients who recovered their baseline renal function, although the recovery time was longer in the second wave.
Table 1.
Characteristics of kidney failure and treatments
Group 1
Group 2
Baseline CKD
G1-2
40 (61%)
36 (63%)
P = .245
G3
16 (26%)
18 (32%)
G4-5
9 (14%)
3 (5%)
ARF severity (KDIGO)
KDIGO 1 and 2
51 (70%)
48 (83%)
P = 0.08
KDIGO 3
22 (30%)
10 (17%)
Cause of ARF
Prerenal
38 (52%)
39 (67%)
P = 0.121
Sepsis
25 (25%)
11 (19%)
Obstructive
2 (3%)
4 (7%)
Others
8 (11%)
4 (7%)
Haematuria
8 (11%)
16 (27%)
P = 0.74
ICU
18 (25%)
3 (5%)
P = 0.03
OTI
16 (22%)
3 (5%)
P = 0.007
RRT
9 (12%)
2 (3%)
P = 0.069
ARF recovery time
7.5 ± 8
16 ± 25
P = 0.04
Total Patients
73
58
Group 1: ARF patients on first wave of SARS CoV2. Group 2: ARF patients on the second wave of SARS CoV2. Baseline CKD, baseline chronic kidney disease; ICU, intensive care unit; OTI, orotracheal intubation; and RRT, renal replacement therapy. ARF recovery time: days from renal failure to recovery of baseline renal function.</description><subject>AKI. Clinical. Epidemiology and Outcome</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkUFrGzEUhEVpoW7ac686FzaWtJa16qFg3LoJcXGI0-Yo3kpaW2UtLZLWkH-SnxsZh0JO5R3m8GYGhg-hz5RcUiLrqTd5uutAk3lzSQh9gyZ0NicVqxv-Fk2Kg1aEE_kefUjpLyFEMiEm6OnXhkn6FS_DYYDoUvA4dHihx2zxjTPePuIVuH6MFjuPbyE763PCDy7v8XZxt62Wmz8Vw9e-szq7kv4-Rud3OO8tXrmYMgZv8NbqUOQBjjadegDf71001doebY-vQhpchv70WXgD_ZgcfETvOuiT_fSiF-j36sf98qpab35eLxfrSlNBacW0JrJtGaktJ2U8E0yCYBQ0NUy0NReN6SiDmsz1TBDJOTcz2rSMzwTMCa8v0Ldz7zC2B2t0mRehV0N0B4iPKoBTrz_e7dUuHJWsm3KyFEzPBTqGlKLt_mUpUScyqpBRL2RUIVMSX86JMA7_NT8D3JCRAg</recordid><startdate>20220503</startdate><enddate>20220503</enddate><creator>Cintra, Melissa</creator><creator>Burgos Martin, Javier</creator><creator>Almenara Tejederas, Marina</creator><creator>Valverde Ortiz, Rocío</creator><creator>Galván Toribio, Raquel</creator><creator>Salguiera Lazo, Mercedes</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20220503</creationdate><title>MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia</title><author>Cintra, Melissa ; Burgos Martin, Javier ; Almenara Tejederas, Marina ; Valverde Ortiz, Rocío ; Galván Toribio, Raquel ; Salguiera Lazo, Mercedes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1711-2cc09bb203e50ac02729a721ac1d27b3578df12a306c4709555d418b2547a6053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>AKI. Clinical. Epidemiology and Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cintra, Melissa</creatorcontrib><creatorcontrib>Burgos Martin, Javier</creatorcontrib><creatorcontrib>Almenara Tejederas, Marina</creatorcontrib><creatorcontrib>Valverde Ortiz, Rocío</creatorcontrib><creatorcontrib>Galván Toribio, Raquel</creatorcontrib><creatorcontrib>Salguiera Lazo, Mercedes</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cintra, Melissa</au><au>Burgos Martin, Javier</au><au>Almenara Tejederas, Marina</au><au>Valverde Ortiz, Rocío</au><au>Galván Toribio, Raquel</au><au>Salguiera Lazo, Mercedes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><date>2022-05-03</date><risdate>2022</risdate><volume>37</volume><issue>Supplement_3</issue><issn>0931-0509</issn><eissn>1460-2385</eissn><abstract>Abstract
BACKGROUND AND AIMS
The incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.
METHOD
A retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who presented with ARF. They correspond to the period from March to May 2020 (G1) and from August to December 2020 (G2). We compare populations, outcomes and treatments.
RESULTS
A total of 73 patients in the first wave (G1), with a cumulative incidence (CI) of 28.3% (G1), compared with 58 patients in the second wave (G2), with a CI of 8% (G2). The mean age was higher in G2 [65.8 ± 15 years (G1); 75.3 ± 14 (G2); P <.05], with no difference regarding sex [63% (G1); 54% (G2)]. In G2, there was a higher proportion of patients with cardiovascular disease [23% (G1); 57% (G2)], hypertension [56% (G1); 83% (G2)]. The baseline glomerular filtration rate (GFR) being similar for both groups (CKD EPI: 69 mL/min/1.73² (G1); P = .27). In the first wave, the mean days from admission to ARF was 3.1 days ± 4.2, and 42% of the patients were diagnosed at admission (31 patients). In the second, it was 2.9 days ± 5.7, of which 60% at admission (35 patients). The most prevalent cause was prerenal in both. Higher proportion in G1 of KDIGO stage 3 (G1: 30% versus G2: 17%) and renal replacement therapy (RRT) (G1: 9 versusG2: 2 patients). Only 3 patients remained in RRT in G1 and 1 patient in G2. In G1, 64% recovered their GFR [mean time (MT): 7.5 ± 8 days], and the percentage of deaths was 34%. In G2, 72% recovered GFR (MT: 16 ± 25 days), and 19% of patients died.
CONCLUSION
Despite a lower age and comorbidity of the first wave patients, the severity and lethality was higher. There were no differences in the proportion of patients who recovered their baseline renal function, although the recovery time was longer in the second wave.
Table 1.
Characteristics of kidney failure and treatments
Group 1
Group 2
Baseline CKD
G1-2
40 (61%)
36 (63%)
P = .245
G3
16 (26%)
18 (32%)
G4-5
9 (14%)
3 (5%)
ARF severity (KDIGO)
KDIGO 1 and 2
51 (70%)
48 (83%)
P = 0.08
KDIGO 3
22 (30%)
10 (17%)
Cause of ARF
Prerenal
38 (52%)
39 (67%)
P = 0.121
Sepsis
25 (25%)
11 (19%)
Obstructive
2 (3%)
4 (7%)
Others
8 (11%)
4 (7%)
Haematuria
8 (11%)
16 (27%)
P = 0.74
ICU
18 (25%)
3 (5%)
P = 0.03
OTI
16 (22%)
3 (5%)
P = 0.007
RRT
9 (12%)
2 (3%)
P = 0.069
ARF recovery time
7.5 ± 8
16 ± 25
P = 0.04
Total Patients
73
58
Group 1: ARF patients on first wave of SARS CoV2. Group 2: ARF patients on the second wave of SARS CoV2. Baseline CKD, baseline chronic kidney disease; ICU, intensive care unit; OTI, orotracheal intubation; and RRT, renal replacement therapy. ARF recovery time: days from renal failure to recovery of baseline renal function.</abstract><pub>Oxford University Press</pub><doi>10.1093/ndt/gfac068.001</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AKI. Clinical. Epidemiology and Outcome |
| title | MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia |
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