Structure–Activity Relationships of Novel Tau Ligands: Passive Fibril Binders and Active Aggregation Inhibitors

Intrinsically disordered proteins (IDPs) are core components of many biological processes and are central players in several pathologies. Despite being important drug targets, attempts to design small-molecule ligands that would help understand and attenuate their behavior are frustrated by the stru...

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Veröffentlicht in:	ACS chemical biology 2022-03, Vol.17 (3), p.701-708
Hauptverfasser:	Baggett, David W, Nath, Abhinav
Format:	Artikel
Sprache:	eng
Schlagworte:	Intrinsically Disordered Proteins - chemistry Ligands Structure-Activity Relationship tau Proteins - metabolism
Online-Zugang:	Volltext
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