Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody
We herein report a case of crescentic glomerulonephritis (GN) associated with infective endocarditis (IE). A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) and anti-gl...
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| Veröffentlicht in: | Internal Medicine 2022/07/15, Vol.61(14), pp.2179-2185 |
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| creator | Chiba, Yuki Takahashi, Kei Makino, Rui Yoshida, Mai Oe, Yuji Nagasawa, Tasuku Sato, Hiroshi Miyazaki, Mariko Okamoto, Koji |
| description | We herein report a case of crescentic glomerulonephritis (GN) associated with infective endocarditis (IE). A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) and anti-glomerular basement membrane (GBM) antibodies. Renal biopsy findings showed crescentic GN with isolated deposition of C3c, a serum conversion product of complement C3. Given these clinical findings, the patient was diagnosed with infective endocardis (IE)-associated GN. Antibiotic therapy was continued without immunosuppressive agents. After the initiation of the antibiotics, the fever resolved, and the renal function gradually recovered. This case highlights the notion that laboratory findings should be carefully evaluated with reference to other findings. |
| doi_str_mv | 10.2169/internalmedicine.8385-21 |
| format | Article |
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A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) and anti-glomerular basement membrane (GBM) antibodies. Renal biopsy findings showed crescentic GN with isolated deposition of C3c, a serum conversion product of complement C3. Given these clinical findings, the patient was diagnosed with infective endocardis (IE)-associated GN. Antibiotic therapy was continued without immunosuppressive agents. After the initiation of the antibiotics, the fever resolved, and the renal function gradually recovered. This case highlights the notion that laboratory findings should be carefully evaluated with reference to other findings.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.8385-21</identifier><identifier>PMID: 34980793</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>anti-glomerular basement membrane antibody ; anti-neutrophil cytoplasmic antibody-associated vasculitis ; Antibiotics ; Antineutrophil cytoplasmic antibodies ; Basement membranes ; Biopsy ; Case Report ; Case reports ; Complement component C3 ; Endocarditis ; Fever ; Glomerulonephritis ; Immunosuppressive agents ; infective endocarditis ; Internal medicine ; Leukocytes (neutrophilic) ; Patients ; Proteinase 3 ; proteinase 3-anti-neutrophil cytoplasmic antibody ; Renal function</subject><ispartof>Internal Medicine, 2022/07/15, Vol.61(14), pp.2179-2185</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-df8fe9c948224017b67e9417e17cbdf09b0e0790cc4dac629cf49f39b2ea43aa3</citedby><cites>FETCH-LOGICAL-c610t-df8fe9c948224017b67e9417e17cbdf09b0e0790cc4dac629cf49f39b2ea43aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381337/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381337/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34980793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiba, Yuki</creatorcontrib><creatorcontrib>Takahashi, Kei</creatorcontrib><creatorcontrib>Makino, Rui</creatorcontrib><creatorcontrib>Yoshida, Mai</creatorcontrib><creatorcontrib>Oe, Yuji</creatorcontrib><creatorcontrib>Nagasawa, Tasuku</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Miyazaki, Mariko</creatorcontrib><creatorcontrib>Okamoto, Koji</creatorcontrib><title>Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report a case of crescentic glomerulonephritis (GN) associated with infective endocarditis (IE). A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) and anti-glomerular basement membrane (GBM) antibodies. Renal biopsy findings showed crescentic GN with isolated deposition of C3c, a serum conversion product of complement C3. Given these clinical findings, the patient was diagnosed with infective endocardis (IE)-associated GN. Antibiotic therapy was continued without immunosuppressive agents. After the initiation of the antibiotics, the fever resolved, and the renal function gradually recovered. This case highlights the notion that laboratory findings should be carefully evaluated with reference to other findings.</description><subject>anti-glomerular basement membrane antibody</subject><subject>anti-neutrophil cytoplasmic antibody-associated vasculitis</subject><subject>Antibiotics</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Basement membranes</subject><subject>Biopsy</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Complement component C3</subject><subject>Endocarditis</subject><subject>Fever</subject><subject>Glomerulonephritis</subject><subject>Immunosuppressive agents</subject><subject>infective endocarditis</subject><subject>Internal medicine</subject><subject>Leukocytes (neutrophilic)</subject><subject>Patients</subject><subject>Proteinase 3</subject><subject>proteinase 3-anti-neutrophil cytoplasmic antibody</subject><subject>Renal function</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplks9u1DAQxiMEokvhFZAlLlxS_CebxBekZVVKpaJWFM6W40wSrxx7sZ2t9r14QLzdJYJyGcv6fvN5ZjxZhgi-oKTkH7SN4K00I7RaaQsXNauXOSXPsgVhBc8rypbPswXmpM5pCmfZqxA2GLO64vRldpaYGlecLbJfV8aN4CfjLGwHr6MOaBWCU1pGaNGDjgO6th2oqHeALm3rlPTtI3Y_uAdte3QP3hnXayUNunMhaTsd96hzHt19Y7m0UecWpujddtAGrffRbY0Mo1ZolbTGtXskbft4yftTOdKjTzLACDairzA2XlqY8dfZi06aAG9O53n24_Pl9_WX_Ob26nq9uslVSXDM267ugCte1JQWmFRNWQEvSAWkUk3bYd5gSFPAShWtVCXlqit4x3hDQRZMSnaefTz6bqcmjVqlYrw0Yuv1KP1eOKnFv4rVg-jdTnBWE8aqZPD-ZODdzwlCFKMOCoxJ3bgpCFqSssSYLklC3z1BN246_PGB4hWpUhc8UfWRUt6F4KGbiyFYHFZDPF0NcViNJKXUt383Myf-2YUE3B6BTYiyhxmQPmpl4H_nkghSHOLpiZlUg_QCLPsNmZfetw</recordid><startdate>20220715</startdate><enddate>20220715</enddate><creator>Chiba, Yuki</creator><creator>Takahashi, Kei</creator><creator>Makino, Rui</creator><creator>Yoshida, Mai</creator><creator>Oe, Yuji</creator><creator>Nagasawa, Tasuku</creator><creator>Sato, Hiroshi</creator><creator>Miyazaki, Mariko</creator><creator>Okamoto, Koji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220715</creationdate><title>Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody</title><author>Chiba, Yuki ; Takahashi, Kei ; Makino, Rui ; Yoshida, Mai ; Oe, Yuji ; Nagasawa, Tasuku ; Sato, Hiroshi ; Miyazaki, Mariko ; Okamoto, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-df8fe9c948224017b67e9417e17cbdf09b0e0790cc4dac629cf49f39b2ea43aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anti-glomerular basement membrane antibody</topic><topic>anti-neutrophil cytoplasmic antibody-associated vasculitis</topic><topic>Antibiotics</topic><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Basement membranes</topic><topic>Biopsy</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Complement component C3</topic><topic>Endocarditis</topic><topic>Fever</topic><topic>Glomerulonephritis</topic><topic>Immunosuppressive agents</topic><topic>infective endocarditis</topic><topic>Internal medicine</topic><topic>Leukocytes (neutrophilic)</topic><topic>Patients</topic><topic>Proteinase 3</topic><topic>proteinase 3-anti-neutrophil cytoplasmic antibody</topic><topic>Renal function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiba, Yuki</creatorcontrib><creatorcontrib>Takahashi, Kei</creatorcontrib><creatorcontrib>Makino, Rui</creatorcontrib><creatorcontrib>Yoshida, Mai</creatorcontrib><creatorcontrib>Oe, Yuji</creatorcontrib><creatorcontrib>Nagasawa, Tasuku</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Miyazaki, Mariko</creatorcontrib><creatorcontrib>Okamoto, Koji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiba, Yuki</au><au>Takahashi, Kei</au><au>Makino, Rui</au><au>Yoshida, Mai</au><au>Oe, Yuji</au><au>Nagasawa, Tasuku</au><au>Sato, Hiroshi</au><au>Miyazaki, Mariko</au><au>Okamoto, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-07-15</date><risdate>2022</risdate><volume>61</volume><issue>14</issue><spage>2179</spage><epage>2185</epage><pages>2179-2185</pages><artnum>8385-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein report a case of crescentic glomerulonephritis (GN) associated with infective endocarditis (IE). A 61-year-old-woman presented with a fever and renal dysfunction and was diagnosed with IE. The patient was positive for proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA) and anti-glomerular basement membrane (GBM) antibodies. Renal biopsy findings showed crescentic GN with isolated deposition of C3c, a serum conversion product of complement C3. Given these clinical findings, the patient was diagnosed with infective endocardis (IE)-associated GN. Antibiotic therapy was continued without immunosuppressive agents. After the initiation of the antibiotics, the fever resolved, and the renal function gradually recovered. This case highlights the notion that laboratory findings should be carefully evaluated with reference to other findings.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>34980793</pmid><doi>10.2169/internalmedicine.8385-21</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | anti-glomerular basement membrane antibody anti-neutrophil cytoplasmic antibody-associated vasculitis Antibiotics Antineutrophil cytoplasmic antibodies Basement membranes Biopsy Case Report Case reports Complement component C3 Endocarditis Fever Glomerulonephritis Immunosuppressive agents infective endocarditis Internal medicine Leukocytes (neutrophilic) Patients Proteinase 3 proteinase 3-anti-neutrophil cytoplasmic antibody Renal function |
| title | Glomerulonephritis Associated with Infective Endocarditis Showing Serological Positivity for PR3-anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody |
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