B7-H3 Specific CAR T Cells for the Naturally Occurring, Spontaneous Canine Sarcoma Model

One obstacle for human solid tumor immunotherapy research is the lack of clinically relevant animal models. In this study, we sought to establish a chimeric antigen receptor (CAR) T-cell treatment model for naturally occurring canine sarcomas as a model for human CAR T-cell therapy. Canine CARs spec...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-06, Vol.21 (6), p.999-1009
Hauptverfasser:	Zhang, Shihong, Black, R Graeme, Kohli, Karan, Hayes, Brian J, Miller, Cassandra, Koehne, Amanda, Schroeder, Brett A, Abrams, Kraig, Schulte, Brian C, Alexiev, Borislav A, Heimberger, Amy B, Zhang, Ali, Jing, Weiqing, Ng, Juliana Chi Kei, Shinglot, Himaly, Seguin, Bernard, Salter, Alexander I, Riddell, Stanley R, Jensen, Michael C, Gottschalk, Stephen, Moore, Peter F, Torok-Storb, Beverly, Pollack, Seth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7 Antigens Cell Line, Tumor Dogs Humans Models and Technologies Receptors, Chimeric Antigen Sarcoma - drug therapy T-Lymphocytes Xenograft Model Antitumor Assays
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