Aaptamine - a dual acetyl - and butyrylcholinesterase inhibitor as potential anti-Alzheimer's disease agent

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are promising therapeutic targets for AD. To evaluate the inhibitory effects of aaptamine on two cholinesterases and investigate the...

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Veröffentlicht in:	Pharmaceutical biology 2022-12, Vol.60 (1), p.1502-1510
Hauptverfasser:	Miao, Shuang, He, Qianqian, Li, Chen, Wu, Yan, Liu, Mengshan, Chen, Yongshou, Qi, Shizhou, Gong, Kaikai
Format:	Artikel
Sprache:	eng
Schlagworte:	Aaptamine Acetylcholinesterase Alzheimer's disease butyrylcholinesterase Donepezil Drug development Dyskinesia dyskinesia rehabilitation molecular docking Neurodegenerative diseases Surface plasmon resonance Therapeutic targets zebrafish
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