Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case
Domoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy. Here the authors describe a xenotr...
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| Veröffentlicht in: | Journal of neurosurgery. Case lessons 2022-03, Vol.3 (12) |
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| container_title | Journal of neurosurgery. Case lessons |
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| creator | Simeone, Claire A Andrews, John P Johnson, Shawn P Casalia, Mariana Kochanski, Ryan Chang, Edward F Cameron, Dianne Dennison, Sophie Inglis, Ben Scott, Gregory Kruse-Elliott, Kris Okonski, F Fabian Calvo, Eric Goulet, Kelly Robles, Dawn Griffin-Stence, Ashley Kuiper, Erin Krasovec, Laura Field, Cara L Hoard, Vanessa F Baraban, Scott C |
| description | Domoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy.
Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized.
These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise. |
| doi_str_mv | 10.3171/CASE21417 |
| format | Article |
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Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized.
These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise.</description><identifier>ISSN: 2694-1902</identifier><identifier>EISSN: 2694-1902</identifier><identifier>DOI: 10.3171/CASE21417</identifier><identifier>PMID: 36273868</identifier><language>eng</language><publisher>United States: American Association of Neurological Surgeons</publisher><subject>Case Lesson</subject><ispartof>Journal of neurosurgery. Case lessons, 2022-03, Vol.3 (12)</ispartof><rights>2022 The authors 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2907-b67909e3b98dacbcc9b92cc9407d27fda9bb6c174986f0c27d710c9abd0edaa53</citedby><cites>FETCH-LOGICAL-c2907-b67909e3b98dacbcc9b92cc9407d27fda9bb6c174986f0c27d710c9abd0edaa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379678/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379678/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36273868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simeone, Claire A</creatorcontrib><creatorcontrib>Andrews, John P</creatorcontrib><creatorcontrib>Johnson, Shawn P</creatorcontrib><creatorcontrib>Casalia, Mariana</creatorcontrib><creatorcontrib>Kochanski, Ryan</creatorcontrib><creatorcontrib>Chang, Edward F</creatorcontrib><creatorcontrib>Cameron, Dianne</creatorcontrib><creatorcontrib>Dennison, Sophie</creatorcontrib><creatorcontrib>Inglis, Ben</creatorcontrib><creatorcontrib>Scott, Gregory</creatorcontrib><creatorcontrib>Kruse-Elliott, Kris</creatorcontrib><creatorcontrib>Okonski, F Fabian</creatorcontrib><creatorcontrib>Calvo, Eric</creatorcontrib><creatorcontrib>Goulet, Kelly</creatorcontrib><creatorcontrib>Robles, Dawn</creatorcontrib><creatorcontrib>Griffin-Stence, Ashley</creatorcontrib><creatorcontrib>Kuiper, Erin</creatorcontrib><creatorcontrib>Krasovec, Laura</creatorcontrib><creatorcontrib>Field, Cara L</creatorcontrib><creatorcontrib>Hoard, Vanessa F</creatorcontrib><creatorcontrib>Baraban, Scott C</creatorcontrib><title>Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case</title><title>Journal of neurosurgery. Case lessons</title><addtitle>J Neurosurg Case Lessons</addtitle><description>Domoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy.
Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized.
These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise.</description><subject>Case Lesson</subject><issn>2694-1902</issn><issn>2694-1902</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVUc1LwzAUD6K4MXfwH5Ac3aGapLVpPAijzA8YeFBBvJQkTbdIloSkHXjyX7djWublvQe_r8d7AJxjdJViiq_L-cuC4AzTIzAmOcsSzBA5PphHYBrjJ0KIMEJSRE7BKM0JTYu8GIPvd2VdG7iN3nDb8lY7C10DvQtSWwV9cCtldesClMqYCLWF3ELltVG-1RKW3OjGBas5jIpDs9NffnDj_LqLUA6o7eLsFmpjutjHtXqrejCqM3DScBPV9LdPwNv94rV8TJbPD0_lfJlIwhBNRE4ZYioVrKi5FFIywUhfM0RrQpuaMyFyiWnGirxBktCaYiQZFzVSNec36QTc7X19Jzaqlsr2W5jKB73h4atyXFf_EavX1cptK5ZSltOiN5jtDWRwMQbVDFqMqt0jquERPffiMGxg_p09_QFqZIhF</recordid><startdate>20220321</startdate><enddate>20220321</enddate><creator>Simeone, Claire A</creator><creator>Andrews, John P</creator><creator>Johnson, Shawn P</creator><creator>Casalia, Mariana</creator><creator>Kochanski, Ryan</creator><creator>Chang, Edward F</creator><creator>Cameron, Dianne</creator><creator>Dennison, Sophie</creator><creator>Inglis, Ben</creator><creator>Scott, Gregory</creator><creator>Kruse-Elliott, Kris</creator><creator>Okonski, F Fabian</creator><creator>Calvo, Eric</creator><creator>Goulet, Kelly</creator><creator>Robles, Dawn</creator><creator>Griffin-Stence, Ashley</creator><creator>Kuiper, Erin</creator><creator>Krasovec, Laura</creator><creator>Field, Cara L</creator><creator>Hoard, Vanessa F</creator><creator>Baraban, Scott C</creator><general>American Association of Neurological Surgeons</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20220321</creationdate><title>Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case</title><author>Simeone, Claire A ; Andrews, John P ; Johnson, Shawn P ; Casalia, Mariana ; Kochanski, Ryan ; Chang, Edward F ; Cameron, Dianne ; Dennison, Sophie ; Inglis, Ben ; Scott, Gregory ; Kruse-Elliott, Kris ; Okonski, F Fabian ; Calvo, Eric ; Goulet, Kelly ; Robles, Dawn ; Griffin-Stence, Ashley ; Kuiper, Erin ; Krasovec, Laura ; Field, Cara L ; Hoard, Vanessa F ; Baraban, Scott C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2907-b67909e3b98dacbcc9b92cc9407d27fda9bb6c174986f0c27d710c9abd0edaa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Case Lesson</topic><toplevel>online_resources</toplevel><creatorcontrib>Simeone, Claire A</creatorcontrib><creatorcontrib>Andrews, John P</creatorcontrib><creatorcontrib>Johnson, Shawn P</creatorcontrib><creatorcontrib>Casalia, Mariana</creatorcontrib><creatorcontrib>Kochanski, Ryan</creatorcontrib><creatorcontrib>Chang, Edward F</creatorcontrib><creatorcontrib>Cameron, Dianne</creatorcontrib><creatorcontrib>Dennison, Sophie</creatorcontrib><creatorcontrib>Inglis, Ben</creatorcontrib><creatorcontrib>Scott, Gregory</creatorcontrib><creatorcontrib>Kruse-Elliott, Kris</creatorcontrib><creatorcontrib>Okonski, F Fabian</creatorcontrib><creatorcontrib>Calvo, Eric</creatorcontrib><creatorcontrib>Goulet, Kelly</creatorcontrib><creatorcontrib>Robles, Dawn</creatorcontrib><creatorcontrib>Griffin-Stence, Ashley</creatorcontrib><creatorcontrib>Kuiper, Erin</creatorcontrib><creatorcontrib>Krasovec, Laura</creatorcontrib><creatorcontrib>Field, Cara L</creatorcontrib><creatorcontrib>Hoard, Vanessa F</creatorcontrib><creatorcontrib>Baraban, Scott C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurosurgery. 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Case lessons</jtitle><addtitle>J Neurosurg Case Lessons</addtitle><date>2022-03-21</date><risdate>2022</risdate><volume>3</volume><issue>12</issue><issn>2694-1902</issn><eissn>2694-1902</eissn><abstract>Domoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy.
Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized.
These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise.</abstract><cop>United States</cop><pub>American Association of Neurological Surgeons</pub><pmid>36273868</pmid><doi>10.3171/CASE21417</doi><oa>free_for_read</oa></addata></record> |
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| title | Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case |
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