Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism
The function of the adipose tissue is influenced by complex interactions between genetics, epigenetics, and the environment, and its dysfunction can cause a variety of metabolic diseases, such as obesity or type 2 diabetes (T2D). The beige/brown adipose tissue plays a crucial role in regulating gluc...
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| Veröffentlicht in: | International journal of biological sciences 2022-01, Vol.18 (13), p.4950-4962 |
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| container_issue | 13 |
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| container_title | International journal of biological sciences |
| container_volume | 18 |
| creator | Wang, Linghui Qiu, Yanhao Gu, Hao Gan, Mailin Zhu, Yan Zhu, Kangping Chen, Lei Zhao, Ye Niu, Lili Zhang, Shunhua Li, Xuewei Zhu, Li Shen, Linyuan |
| description | The function of the adipose tissue is influenced by complex interactions between genetics, epigenetics, and the environment, and its dysfunction can cause a variety of metabolic diseases, such as obesity or type 2 diabetes (T2D). The beige/brown adipose tissue plays a crucial role in regulating glucose and lipid metabolism by increasing energy metabolism to generate heat. The adipose tissue thermogenic program is a complex network that involves many signaling pathways regulated by coding RNAs (cRNAs) that encode transcription factor, and non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). This article discusses factors that regulate adipose tissue thermogenesis, including cRNAs and ncRNAs, and the important role of thermogenic adipose tissue in obesity-related metabolic syndrome. Several studies have shown that some cRNAs and ncRNAs can modulate the thermogenic function of adipose tissue in different ways. This article reviews the roles of cRNAs and ncRNAs in regulating thermogenesis in the beige/brown adipose tissue and the important role of the beige/brown adipose tissue in maintaining the balance of glucose and lipid metabolism in the body. |
| doi_str_mv | 10.7150/ijbs.75488 |
| format | Article |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Review |
| title | Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism |
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