Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients with HGSC. Epigenetic silencing of immunostimulatory genes is implicated in immune evasion in H...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-04, Vol.21 (4), p.522-534
Hauptverfasser:	Spiliopoulou, Pavlina, Spear, Sarah, Mirza, Hasan, Garner, Ian, McGarry, Lynn, Grundland-Freile, Fabio, Cheng, Zhao, Ennis, Darren P, Iyer, Nayana, McNamara, Sophie, Natoli, Marina, Mason, Susan, Blyth, Karen, Adams, Peter D, Roxburgh, Patricia, Fuchter, Matthew J, Brown, Bob, McNeish, Iain A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Ovarian Epithelial - genetics Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Enhancer of Zeste Homolog 2 Protein - genetics Epigenesis, Genetic Humans Immunity Mice Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Prognosis Small Molecule Therapeutics Tumor Microenvironment
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