Infertility and Risk of Heart Failure in the Women’s Health Initiative
There is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with fut...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2022-04, Vol.79 (16), p.1594-1603 |
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| creator | Lau, Emily S. Wang, Dongyu Roberts, Mary Taylor, Christy N. Murugappan, Gayathree Shadyab, Aladdin H. Schnatz, Peter F. Farland, Leslie V. Wood, Malissa J. Scott, Nandita S. Eaton, Charles B. Ho, Jennifer E. |
| description | There is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with future risk of heart failure (HF) is not known.
This study sought to examine the development of HF and HF subtypes in women with and without history of infertility.
We followed postmenopausal women from the Women’s Health Initiative prospectively for the development of HF. Infertility was self-reported at study baseline. Multivariable cause-specific Cox models were used to evaluate the association of infertility with incident overall HF and HF subtypes (heart failure with preserved ejection fraction [HFpEF]: left ventricular ejection fraction of ≥50% vs heart failure with reduced ejection fraction [HFrEF]: left ventricular ejection fraction of |
| doi_str_mv | 10.1016/j.jacc.2022.02.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9377329</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735109722004557</els_id><sourcerecordid>2654277945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-da76fbef665f6d6499773804f85edd481aca82b1e5edb2f02d58d350c2debc843</originalsourceid><addsrcrecordid>eNp9UcFq3DAQFSWh2Wz7Az0UH3PxdiRblg0lEEKSXQgEQkqPQpZGXW29cippF3LLb-TWb8mn5Etqs2lILoGBYXhv3hvmEfKFwowCrb6tZiul9YwBYzMYCz6QCeW8zgveiD0yAVHwnEIjDshhjCsAqGrafCQHBS85cCEmZLHwFkNynUt3mfImu3bxd9bbbI4qpMe_58p1m4CZ81laYvazX6N_un-II96lZbbwLjmV3BY_kX2ruoifn_uU_Dg_uzmd55dXF4vTk8tcc0ZTbpSobIu2qritTFU2jRBFDaWtORpT1lRpVbOW4jC2zAIzvDYFB80Mtrouiyk53unebto1Go0-BdXJ2-DWKtzJXjn5FvFuKX_1W9kUgxNrBoGjZ4HQ_9lgTHLtosauUx77TZSs4iUToin5QGU7qg59jAHtiw0FOWYgV3LMQI4ZSBgLhqWvrw98Wfn_9IHwfUfA4U1bh0FG7dBrNC6gTtL07j39f9LRmvY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2654277945</pqid></control><display><type>article</type><title>Infertility and Risk of Heart Failure in the Women’s Health Initiative</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Lau, Emily S. ; Wang, Dongyu ; Roberts, Mary ; Taylor, Christy N. ; Murugappan, Gayathree ; Shadyab, Aladdin H. ; Schnatz, Peter F. ; Farland, Leslie V. ; Wood, Malissa J. ; Scott, Nandita S. ; Eaton, Charles B. ; Ho, Jennifer E.</creator><creatorcontrib>Lau, Emily S. ; Wang, Dongyu ; Roberts, Mary ; Taylor, Christy N. ; Murugappan, Gayathree ; Shadyab, Aladdin H. ; Schnatz, Peter F. ; Farland, Leslie V. ; Wood, Malissa J. ; Scott, Nandita S. ; Eaton, Charles B. ; Ho, Jennifer E.</creatorcontrib><description>There is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with future risk of heart failure (HF) is not known.
This study sought to examine the development of HF and HF subtypes in women with and without history of infertility.
We followed postmenopausal women from the Women’s Health Initiative prospectively for the development of HF. Infertility was self-reported at study baseline. Multivariable cause-specific Cox models were used to evaluate the association of infertility with incident overall HF and HF subtypes (heart failure with preserved ejection fraction [HFpEF]: left ventricular ejection fraction of ≥50% vs heart failure with reduced ejection fraction [HFrEF]: left ventricular ejection fraction of <50%]).
Among 38,528 postmenopausal women (mean age: 63 ± 7 years), 5,399 (14%) participants reported a history of infertility. Over a median follow-up of 15 years, 2,373 developed incident HF, including 807 with HFrEF and 1,133 with HFpEF. Infertility was independently associated with future risk of overall HF (HR: 1.16; 95% CI: 1.04-1.30; P = 0.006). Notably, when examining HF subtypes, infertility was associated with future risk of HFpEF (HR: 1.27; 95% CI: 1.09-1.48; P = 0.002) but not HFrEF (HR: 0.97; 95% CI: 0.80-1.18).
Infertility was significantly associated with incident HF. This was driven by increased risk of HFpEF, but not HFrEF, and appeared independent of traditional cardiovascular risk factors and other infertility-related conditions. Future research should investigate mechanisms that underlie the link between infertility and HFpEF.
[Display omitted]</description><identifier>ISSN: 0735-1097</identifier><identifier>ISSN: 1558-3597</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2022.02.020</identifier><identifier>PMID: 35450577</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Cardiovascular Diseases ; Female ; heart failure ; Heart Failure - epidemiology ; Humans ; Infertility ; Middle Aged ; Prognosis ; Risk Factors ; Stroke Volume ; Ventricular Function, Left ; women ; Women's Health</subject><ispartof>Journal of the American College of Cardiology, 2022-04, Vol.79 (16), p.1594-1603</ispartof><rights>2022 American College of Cardiology Foundation</rights><rights>Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-da76fbef665f6d6499773804f85edd481aca82b1e5edb2f02d58d350c2debc843</citedby><cites>FETCH-LOGICAL-c521t-da76fbef665f6d6499773804f85edd481aca82b1e5edb2f02d58d350c2debc843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109722004557$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35450577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, Emily S.</creatorcontrib><creatorcontrib>Wang, Dongyu</creatorcontrib><creatorcontrib>Roberts, Mary</creatorcontrib><creatorcontrib>Taylor, Christy N.</creatorcontrib><creatorcontrib>Murugappan, Gayathree</creatorcontrib><creatorcontrib>Shadyab, Aladdin H.</creatorcontrib><creatorcontrib>Schnatz, Peter F.</creatorcontrib><creatorcontrib>Farland, Leslie V.</creatorcontrib><creatorcontrib>Wood, Malissa J.</creatorcontrib><creatorcontrib>Scott, Nandita S.</creatorcontrib><creatorcontrib>Eaton, Charles B.</creatorcontrib><creatorcontrib>Ho, Jennifer E.</creatorcontrib><title>Infertility and Risk of Heart Failure in the Women’s Health Initiative</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>There is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with future risk of heart failure (HF) is not known.
This study sought to examine the development of HF and HF subtypes in women with and without history of infertility.
We followed postmenopausal women from the Women’s Health Initiative prospectively for the development of HF. Infertility was self-reported at study baseline. Multivariable cause-specific Cox models were used to evaluate the association of infertility with incident overall HF and HF subtypes (heart failure with preserved ejection fraction [HFpEF]: left ventricular ejection fraction of ≥50% vs heart failure with reduced ejection fraction [HFrEF]: left ventricular ejection fraction of <50%]).
Among 38,528 postmenopausal women (mean age: 63 ± 7 years), 5,399 (14%) participants reported a history of infertility. Over a median follow-up of 15 years, 2,373 developed incident HF, including 807 with HFrEF and 1,133 with HFpEF. Infertility was independently associated with future risk of overall HF (HR: 1.16; 95% CI: 1.04-1.30; P = 0.006). Notably, when examining HF subtypes, infertility was associated with future risk of HFpEF (HR: 1.27; 95% CI: 1.09-1.48; P = 0.002) but not HFrEF (HR: 0.97; 95% CI: 0.80-1.18).
Infertility was significantly associated with incident HF. This was driven by increased risk of HFpEF, but not HFrEF, and appeared independent of traditional cardiovascular risk factors and other infertility-related conditions. Future research should investigate mechanisms that underlie the link between infertility and HFpEF.
[Display omitted]</description><subject>Aged</subject><subject>Cardiovascular Diseases</subject><subject>Female</subject><subject>heart failure</subject><subject>Heart Failure - epidemiology</subject><subject>Humans</subject><subject>Infertility</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><subject>women</subject><subject>Women's Health</subject><issn>0735-1097</issn><issn>1558-3597</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFq3DAQFSWh2Wz7Az0UH3PxdiRblg0lEEKSXQgEQkqPQpZGXW29cippF3LLb-TWb8mn5Etqs2lILoGBYXhv3hvmEfKFwowCrb6tZiul9YwBYzMYCz6QCeW8zgveiD0yAVHwnEIjDshhjCsAqGrafCQHBS85cCEmZLHwFkNynUt3mfImu3bxd9bbbI4qpMe_58p1m4CZ81laYvazX6N_un-II96lZbbwLjmV3BY_kX2ruoifn_uU_Dg_uzmd55dXF4vTk8tcc0ZTbpSobIu2qritTFU2jRBFDaWtORpT1lRpVbOW4jC2zAIzvDYFB80Mtrouiyk53unebto1Go0-BdXJ2-DWKtzJXjn5FvFuKX_1W9kUgxNrBoGjZ4HQ_9lgTHLtosauUx77TZSs4iUToin5QGU7qg59jAHtiw0FOWYgV3LMQI4ZSBgLhqWvrw98Wfn_9IHwfUfA4U1bh0FG7dBrNC6gTtL07j39f9LRmvY</recordid><startdate>20220426</startdate><enddate>20220426</enddate><creator>Lau, Emily S.</creator><creator>Wang, Dongyu</creator><creator>Roberts, Mary</creator><creator>Taylor, Christy N.</creator><creator>Murugappan, Gayathree</creator><creator>Shadyab, Aladdin H.</creator><creator>Schnatz, Peter F.</creator><creator>Farland, Leslie V.</creator><creator>Wood, Malissa J.</creator><creator>Scott, Nandita S.</creator><creator>Eaton, Charles B.</creator><creator>Ho, Jennifer E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220426</creationdate><title>Infertility and Risk of Heart Failure in the Women’s Health Initiative</title><author>Lau, Emily S. ; Wang, Dongyu ; Roberts, Mary ; Taylor, Christy N. ; Murugappan, Gayathree ; Shadyab, Aladdin H. ; Schnatz, Peter F. ; Farland, Leslie V. ; Wood, Malissa J. ; Scott, Nandita S. ; Eaton, Charles B. ; Ho, Jennifer E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-da76fbef665f6d6499773804f85edd481aca82b1e5edb2f02d58d350c2debc843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Cardiovascular Diseases</topic><topic>Female</topic><topic>heart failure</topic><topic>Heart Failure - epidemiology</topic><topic>Humans</topic><topic>Infertility</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><topic>women</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, Emily S.</creatorcontrib><creatorcontrib>Wang, Dongyu</creatorcontrib><creatorcontrib>Roberts, Mary</creatorcontrib><creatorcontrib>Taylor, Christy N.</creatorcontrib><creatorcontrib>Murugappan, Gayathree</creatorcontrib><creatorcontrib>Shadyab, Aladdin H.</creatorcontrib><creatorcontrib>Schnatz, Peter F.</creatorcontrib><creatorcontrib>Farland, Leslie V.</creatorcontrib><creatorcontrib>Wood, Malissa J.</creatorcontrib><creatorcontrib>Scott, Nandita S.</creatorcontrib><creatorcontrib>Eaton, Charles B.</creatorcontrib><creatorcontrib>Ho, Jennifer E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, Emily S.</au><au>Wang, Dongyu</au><au>Roberts, Mary</au><au>Taylor, Christy N.</au><au>Murugappan, Gayathree</au><au>Shadyab, Aladdin H.</au><au>Schnatz, Peter F.</au><au>Farland, Leslie V.</au><au>Wood, Malissa J.</au><au>Scott, Nandita S.</au><au>Eaton, Charles B.</au><au>Ho, Jennifer E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infertility and Risk of Heart Failure in the Women’s Health Initiative</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2022-04-26</date><risdate>2022</risdate><volume>79</volume><issue>16</issue><spage>1594</spage><epage>1603</epage><pages>1594-1603</pages><issn>0735-1097</issn><issn>1558-3597</issn><eissn>1558-3597</eissn><abstract>There is growing recognition that reproductive factors are associated with increased risk of future cardiovascular disease. Infertility has been less well studied, although emerging data support its association with increased risk of cardiovascular disease. Whether infertility is associated with future risk of heart failure (HF) is not known.
This study sought to examine the development of HF and HF subtypes in women with and without history of infertility.
We followed postmenopausal women from the Women’s Health Initiative prospectively for the development of HF. Infertility was self-reported at study baseline. Multivariable cause-specific Cox models were used to evaluate the association of infertility with incident overall HF and HF subtypes (heart failure with preserved ejection fraction [HFpEF]: left ventricular ejection fraction of ≥50% vs heart failure with reduced ejection fraction [HFrEF]: left ventricular ejection fraction of <50%]).
Among 38,528 postmenopausal women (mean age: 63 ± 7 years), 5,399 (14%) participants reported a history of infertility. Over a median follow-up of 15 years, 2,373 developed incident HF, including 807 with HFrEF and 1,133 with HFpEF. Infertility was independently associated with future risk of overall HF (HR: 1.16; 95% CI: 1.04-1.30; P = 0.006). Notably, when examining HF subtypes, infertility was associated with future risk of HFpEF (HR: 1.27; 95% CI: 1.09-1.48; P = 0.002) but not HFrEF (HR: 0.97; 95% CI: 0.80-1.18).
Infertility was significantly associated with incident HF. This was driven by increased risk of HFpEF, but not HFrEF, and appeared independent of traditional cardiovascular risk factors and other infertility-related conditions. Future research should investigate mechanisms that underlie the link between infertility and HFpEF.
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35450577</pmid><doi>10.1016/j.jacc.2022.02.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 2022-04, Vol.79 (16), p.1594-1603 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Cardiovascular Diseases Female heart failure Heart Failure - epidemiology Humans Infertility Middle Aged Prognosis Risk Factors Stroke Volume Ventricular Function, Left women Women's Health |
| title | Infertility and Risk of Heart Failure in the Women’s Health Initiative |
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