Erosion protection comparison of stabilised SnF2, mixed fluoride active and SMFP/arginine-containing dentifrices

Purpose To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model. Methods Sound enamel cores from e...

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Veröffentlicht in:International dental journal 2014-03, Vol.64 (s1), p.22-28
Hauptverfasser: Eversole, Sandra L., Saunders-Burkhardt, Kymberly, Faller, Robert V.
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creator Eversole, Sandra L.
Saunders-Burkhardt, Kymberly
Faller, Robert V.
description Purpose To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model. Methods Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate. Results Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products. Conclusions These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.
doi_str_mv 10.1111/idj.12099
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Methods Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate. Results Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products. Conclusions These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.</description><identifier>ISSN: 0020-6539</identifier><identifier>EISSN: 1875-595X</identifier><identifier>DOI: 10.1111/idj.12099</identifier><identifier>PMID: 24571701</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Arginine - therapeutic use ; arginine bicarbonate ; Citric Acid - adverse effects ; Complex Mixtures - therapeutic use ; Dental Enamel - drug effects ; Dental Enamel - ultrastructure ; Dental Pellicle - physiology ; dentifrice ; Dentifrices - therapeutic use ; Dentistry ; Erosion ; fluoride ; Fluorides ; Fluorides - therapeutic use ; Humans ; Hydrogen-Ion Concentration ; Microradiography - methods ; mixed fluoride ; Original ; Phosphates - therapeutic use ; Potassium Compounds - therapeutic use ; Protective Agents - therapeutic use ; Saliva - physiology ; Silicic Acid - therapeutic use ; Sodium Fluoride - therapeutic use ; stannous fluoride ; Tin Fluorides - therapeutic use ; Tooth Erosion - pathology ; Tooth Erosion - prevention &amp; control ; Toothpastes - therapeutic use</subject><ispartof>International dental journal, 2014-03, Vol.64 (s1), p.22-28</ispartof><rights>2014 FDI World Dental Federation</rights><rights>2014 FDI World Dental Federation.</rights><rights>Copyright © 2014 FDI World Dental Federation</rights><rights>Copyright © 2014 FDI World Dental Federation. Published by Elsevier Inc. 2014 FDI World Dental Federation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4819-ec2a2db38574ecd2ad1a99165cec836ef410798fb2212278b4a416ec95178b4d3</citedby><cites>FETCH-LOGICAL-c4819-ec2a2db38574ecd2ad1a99165cec836ef410798fb2212278b4a416ec95178b4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376538/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376538/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24571701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eversole, Sandra L.</creatorcontrib><creatorcontrib>Saunders-Burkhardt, Kymberly</creatorcontrib><creatorcontrib>Faller, Robert V.</creatorcontrib><title>Erosion protection comparison of stabilised SnF2, mixed fluoride active and SMFP/arginine-containing dentifrices</title><title>International dental journal</title><addtitle>Int Dent J</addtitle><description>Purpose To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model. Methods Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate. Results Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products. Conclusions These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.</description><subject>Arginine - therapeutic use</subject><subject>arginine bicarbonate</subject><subject>Citric Acid - adverse effects</subject><subject>Complex Mixtures - therapeutic use</subject><subject>Dental Enamel - drug effects</subject><subject>Dental Enamel - ultrastructure</subject><subject>Dental Pellicle - physiology</subject><subject>dentifrice</subject><subject>Dentifrices - therapeutic use</subject><subject>Dentistry</subject><subject>Erosion</subject><subject>fluoride</subject><subject>Fluorides</subject><subject>Fluorides - therapeutic use</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Microradiography - methods</subject><subject>mixed fluoride</subject><subject>Original</subject><subject>Phosphates - therapeutic use</subject><subject>Potassium Compounds - therapeutic use</subject><subject>Protective Agents - therapeutic use</subject><subject>Saliva - physiology</subject><subject>Silicic Acid - therapeutic use</subject><subject>Sodium Fluoride - therapeutic use</subject><subject>stannous fluoride</subject><subject>Tin Fluorides - therapeutic use</subject><subject>Tooth Erosion - pathology</subject><subject>Tooth Erosion - prevention &amp; control</subject><subject>Toothpastes - therapeutic use</subject><issn>0020-6539</issn><issn>1875-595X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtv1DAQhS0EokvhgT-AIvECEun6EsfxCxIq3aWoXERB9M1ynMniJbGDnZT23-Ow7QqQ8IuPNd8cjecg9JjgI5LO0jbbI0KxlHfQglSC51zyi7togTHFecmZPEAPYtxiXFQMl_fRAS24IAKTBRpOgo_Wu2wIfgQzztL4ftDBxiR9m8VR17azEZrs3K3oi6y3V0m33eSDbSDTqekyXS7V360-LnXYWGcd5Ma7Uc9ykzXgRtsGayA-RPda3UV4dHMfoi-rk8_Hb_KzD-vT41dnuSkqInMwVNOmZhUXBZiG6oZoKUnJDZiKldAWBAtZtTWlhFJR1YUuSAlGcjI_GnaIXu58h6nuoTFpgqA7NQTb63CtvLbq74qz39TGXyrJRFpZlQye3RgE_2OCOKreRgNdpx34KSrCMeNF2iRL6NN_0K2fgkvfmyksMKdVkajnO8qklccA7X4YgtWco0o5qt85JvbJn9PvydvgErDcAT9tB9f_d1Knr9_eWua7DhtHuNp36PBdlYIJrr6-X6tPJTundI3VBfsFbaG3xQ</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Eversole, Sandra L.</creator><creator>Saunders-Burkhardt, Kymberly</creator><creator>Faller, Robert V.</creator><general>Blackwell Publishing Ltd</general><general>Elsevier Limited</general><general>Elsevier</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Erosion protection comparison of stabilised SnF2, mixed fluoride active and SMFP/arginine-containing dentifrices</title><author>Eversole, Sandra L. ; Saunders-Burkhardt, Kymberly ; Faller, Robert V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4819-ec2a2db38574ecd2ad1a99165cec836ef410798fb2212278b4a416ec95178b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Arginine - therapeutic use</topic><topic>arginine bicarbonate</topic><topic>Citric Acid - adverse effects</topic><topic>Complex Mixtures - therapeutic use</topic><topic>Dental Enamel - drug effects</topic><topic>Dental Enamel - ultrastructure</topic><topic>Dental Pellicle - physiology</topic><topic>dentifrice</topic><topic>Dentifrices - therapeutic use</topic><topic>Dentistry</topic><topic>Erosion</topic><topic>fluoride</topic><topic>Fluorides</topic><topic>Fluorides - therapeutic use</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Microradiography - methods</topic><topic>mixed fluoride</topic><topic>Original</topic><topic>Phosphates - therapeutic use</topic><topic>Potassium Compounds - therapeutic use</topic><topic>Protective Agents - therapeutic use</topic><topic>Saliva - physiology</topic><topic>Silicic Acid - therapeutic use</topic><topic>Sodium Fluoride - therapeutic use</topic><topic>stannous fluoride</topic><topic>Tin Fluorides - therapeutic use</topic><topic>Tooth Erosion - pathology</topic><topic>Tooth Erosion - prevention &amp; control</topic><topic>Toothpastes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eversole, Sandra L.</creatorcontrib><creatorcontrib>Saunders-Burkhardt, Kymberly</creatorcontrib><creatorcontrib>Faller, Robert V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International dental journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eversole, Sandra L.</au><au>Saunders-Burkhardt, Kymberly</au><au>Faller, Robert V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erosion protection comparison of stabilised SnF2, mixed fluoride active and SMFP/arginine-containing dentifrices</atitle><jtitle>International dental journal</jtitle><addtitle>Int Dent J</addtitle><date>2014-03</date><risdate>2014</risdate><volume>64</volume><issue>s1</issue><spage>22</spage><epage>28</epage><pages>22-28</pages><issn>0020-6539</issn><eissn>1875-595X</eissn><abstract>Purpose To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model. Methods Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate. Results Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products. Conclusions These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24571701</pmid><doi>10.1111/idj.12099</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection
subjects Arginine - therapeutic use
arginine bicarbonate
Citric Acid - adverse effects
Complex Mixtures - therapeutic use
Dental Enamel - drug effects
Dental Enamel - ultrastructure
Dental Pellicle - physiology
dentifrice
Dentifrices - therapeutic use
Dentistry
Erosion
fluoride
Fluorides
Fluorides - therapeutic use
Humans
Hydrogen-Ion Concentration
Microradiography - methods
mixed fluoride
Original
Phosphates - therapeutic use
Potassium Compounds - therapeutic use
Protective Agents - therapeutic use
Saliva - physiology
Silicic Acid - therapeutic use
Sodium Fluoride - therapeutic use
stannous fluoride
Tin Fluorides - therapeutic use
Tooth Erosion - pathology
Tooth Erosion - prevention & control
Toothpastes - therapeutic use
title Erosion protection comparison of stabilised SnF2, mixed fluoride active and SMFP/arginine-containing dentifrices
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