Evaluating the state of the science for adeno-associated virus integration: An integrated perspective

On August 18, 2021, the American Society of Gene and Cell Therapy (ASGCT) hosted a virtual roundtable on adeno-associated virus (AAV) integration, featuring leading experts in preclinical and clinical AAV gene therapy, to further contextualize and understand this phenomenon. Recombinant AAV (rAAV) v...

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Veröffentlicht in:	Molecular therapy 2022-08, Vol.30 (8), p.2646-2663
Hauptverfasser:	Sabatino, Denise E., Bushman, Frederic D., Chandler, Randy J., Crystal, Ronald G., Davidson, Beverly L., Dolmetsch, Ricardo, Eggan, Kevin C., Gao, Guangping, Gil-Farina, Irene, Kay, Mark A., McCarty, Douglas M., Montini, Eugenio, Ndu, Adora, Yuan, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	AAV Animals bioethics clonal expansion Dependovirus - genetics Genetic Vectors - genetics genome integration genotoxicity hepatocellular carcinoma (HCC) Humans insertional mutagenesis Mice Mutagenesis, Insertional next-generation sequencing oncogenicity risk Plasmids recombinant AAV (rAAV) Review Transgenes Virus Integration
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