Kidney failure, CKD progression and mortality after nephrectomy
Purpose This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes. Methods A sample of 5983 patients from five specialist nephrology practices was ascertained from the...
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| Veröffentlicht in: | International urology and nephrology 2022-09, Vol.54 (9), p.2239-2245 |
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| creator | Ellis, Robert J. Cameron, Anne Gobe, Glenda C. Diwan, Vishal Healy, Helen G. Lee, Jeremy Tan, Ken-Soon Venuthurupalli, Sree Zhang, Jianzhen Hoy, Wendy E. |
| description | Purpose
This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.
Methods
A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.
Results
Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR |
| doi_str_mv | 10.1007/s11255-022-03114-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9371989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2623329470</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-37f8112aafdaf6e4b40081d05700db6b133b586744e2dc025068f0b8b2020bd73</originalsourceid><addsrcrecordid>eNp9kUtLxDAUhYMoOj7-gAspuHFh9ebVpBtFxicjuNF1SNt07NAmY9IK8-_NOL4Xrm7gfjn3HA5C-xhOMIA4DRgTzlMgJAWKMUvFGhphLmhKuGTrP95baDuEGQDkEmATbVEOkmUcRuh80lTWLJJaN-3gzXEynlwmc--m3oTQOJtoWyWd871um36R6Lo3PrFm_uxN2btusYs2at0Gs_cxd9DT9dXj-Da9f7i5G1_cpyUTrE-pqGV0q3Vd6TozrGAAElfABUBVZAWmtOAyE4wZUpVAOGSyhkIWBAgUlaA76GylOx-KzlSlsb3XrZr7ptN-oZxu1O-NbZ7V1L2qnAqcyzwKHH0IePcymNCrrgmlaVttjRuCIhmhlORMQEQP_6AzN3gb4ykS_eaQY5xFiqyo0rsQvKm_zGBQy37Uqh8V-1Hv_ahljIOfMb6-fBYSAboCQlzZqfHft_-RfQM2AZqH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2700909116</pqid></control><display><type>article</type><title>Kidney failure, CKD progression and mortality after nephrectomy</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ellis, Robert J. ; Cameron, Anne ; Gobe, Glenda C. ; Diwan, Vishal ; Healy, Helen G. ; Lee, Jeremy ; Tan, Ken-Soon ; Venuthurupalli, Sree ; Zhang, Jianzhen ; Hoy, Wendy E.</creator><creatorcontrib>Ellis, Robert J. ; Cameron, Anne ; Gobe, Glenda C. ; Diwan, Vishal ; Healy, Helen G. ; Lee, Jeremy ; Tan, Ken-Soon ; Venuthurupalli, Sree ; Zhang, Jianzhen ; Hoy, Wendy E. ; NHMRC CKD.CRE, the CKD.QLD Collaborative ; the NHMRC CKD.CRE, the CKD.QLD Collaborative</creatorcontrib><description>Purpose
This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.
Methods
A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.
Results
Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR < 45 mL/min per 1.73m
2
at recruitment, patients with diabetic nephropathy and PCKD had the highest rates (per 1000 person-years) of kidney failure (107.8, 95% CI 71.0–163.8; 75.5, 95% CI 65.6–87.1); whereas, patients with glomerulonephritis and an acquired single kidney had lower rates (52.9, 95% CI 38.8–72.1; 34.6, 95% CI 20.5–58.4, respectively). Among patients with an eGFR ≥ 45 mL/min per 1.73m
2
, those with diabetic nephropathy had the highest rates of kidney failure (16.6, 95% CI 92.5–117.3); whereas, those with glomerulonephritis, PCKD and acquired single kidney had a lower risk (11.3, 95% CI 7.1–17.9; 11.7, 95% CI 3.8–36.2; 10.7, 95% CI 4.0–28.4, respectively).
Conclusion
Patients who developed CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes. While CKD after nephrectomy is not the most aggressive cause of kidney disease, it is by no means benign, and is associated with a tangible risk of kidney failure and death, which is comparable to other major causes of CKD.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-022-03114-7</identifier><identifier>PMID: 35084650</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Diabetes ; Diabetes mellitus ; Diabetic nephropathy ; Epidermal growth factor receptors ; Glomerulonephritis ; Kidney diseases ; Medicine ; Medicine & Public Health ; Nephrectomy ; Nephrology ; Nephrology - Original Paper ; Nephropathy ; Renal failure ; Urology</subject><ispartof>International urology and nephrology, 2022-09, Vol.54 (9), p.2239-2245</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-37f8112aafdaf6e4b40081d05700db6b133b586744e2dc025068f0b8b2020bd73</citedby><cites>FETCH-LOGICAL-c474t-37f8112aafdaf6e4b40081d05700db6b133b586744e2dc025068f0b8b2020bd73</cites><orcidid>0000-0002-9755-9913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-022-03114-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-022-03114-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35084650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, Robert J.</creatorcontrib><creatorcontrib>Cameron, Anne</creatorcontrib><creatorcontrib>Gobe, Glenda C.</creatorcontrib><creatorcontrib>Diwan, Vishal</creatorcontrib><creatorcontrib>Healy, Helen G.</creatorcontrib><creatorcontrib>Lee, Jeremy</creatorcontrib><creatorcontrib>Tan, Ken-Soon</creatorcontrib><creatorcontrib>Venuthurupalli, Sree</creatorcontrib><creatorcontrib>Zhang, Jianzhen</creatorcontrib><creatorcontrib>Hoy, Wendy E.</creatorcontrib><creatorcontrib>NHMRC CKD.CRE, the CKD.QLD Collaborative</creatorcontrib><creatorcontrib>the NHMRC CKD.CRE, the CKD.QLD Collaborative</creatorcontrib><title>Kidney failure, CKD progression and mortality after nephrectomy</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Purpose
This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.
Methods
A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.
Results
Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR < 45 mL/min per 1.73m
2
at recruitment, patients with diabetic nephropathy and PCKD had the highest rates (per 1000 person-years) of kidney failure (107.8, 95% CI 71.0–163.8; 75.5, 95% CI 65.6–87.1); whereas, patients with glomerulonephritis and an acquired single kidney had lower rates (52.9, 95% CI 38.8–72.1; 34.6, 95% CI 20.5–58.4, respectively). Among patients with an eGFR ≥ 45 mL/min per 1.73m
2
, those with diabetic nephropathy had the highest rates of kidney failure (16.6, 95% CI 92.5–117.3); whereas, those with glomerulonephritis, PCKD and acquired single kidney had a lower risk (11.3, 95% CI 7.1–17.9; 11.7, 95% CI 3.8–36.2; 10.7, 95% CI 4.0–28.4, respectively).
Conclusion
Patients who developed CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes. While CKD after nephrectomy is not the most aggressive cause of kidney disease, it is by no means benign, and is associated with a tangible risk of kidney failure and death, which is comparable to other major causes of CKD.</description><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic nephropathy</subject><subject>Epidermal growth factor receptors</subject><subject>Glomerulonephritis</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrectomy</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Nephropathy</subject><subject>Renal failure</subject><subject>Urology</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtLxDAUhYMoOj7-gAspuHFh9ebVpBtFxicjuNF1SNt07NAmY9IK8-_NOL4Xrm7gfjn3HA5C-xhOMIA4DRgTzlMgJAWKMUvFGhphLmhKuGTrP95baDuEGQDkEmATbVEOkmUcRuh80lTWLJJaN-3gzXEynlwmc--m3oTQOJtoWyWd871um36R6Lo3PrFm_uxN2btusYs2at0Gs_cxd9DT9dXj-Da9f7i5G1_cpyUTrE-pqGV0q3Vd6TozrGAAElfABUBVZAWmtOAyE4wZUpVAOGSyhkIWBAgUlaA76GylOx-KzlSlsb3XrZr7ptN-oZxu1O-NbZ7V1L2qnAqcyzwKHH0IePcymNCrrgmlaVttjRuCIhmhlORMQEQP_6AzN3gb4ykS_eaQY5xFiqyo0rsQvKm_zGBQy37Uqh8V-1Hv_ahljIOfMb6-fBYSAboCQlzZqfHft_-RfQM2AZqH</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Ellis, Robert J.</creator><creator>Cameron, Anne</creator><creator>Gobe, Glenda C.</creator><creator>Diwan, Vishal</creator><creator>Healy, Helen G.</creator><creator>Lee, Jeremy</creator><creator>Tan, Ken-Soon</creator><creator>Venuthurupalli, Sree</creator><creator>Zhang, Jianzhen</creator><creator>Hoy, Wendy E.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9755-9913</orcidid></search><sort><creationdate>20220901</creationdate><title>Kidney failure, CKD progression and mortality after nephrectomy</title><author>Ellis, Robert J. ; Cameron, Anne ; Gobe, Glenda C. ; Diwan, Vishal ; Healy, Helen G. ; Lee, Jeremy ; Tan, Ken-Soon ; Venuthurupalli, Sree ; Zhang, Jianzhen ; Hoy, Wendy E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-37f8112aafdaf6e4b40081d05700db6b133b586744e2dc025068f0b8b2020bd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic nephropathy</topic><topic>Epidermal growth factor receptors</topic><topic>Glomerulonephritis</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrectomy</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Nephropathy</topic><topic>Renal failure</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellis, Robert J.</creatorcontrib><creatorcontrib>Cameron, Anne</creatorcontrib><creatorcontrib>Gobe, Glenda C.</creatorcontrib><creatorcontrib>Diwan, Vishal</creatorcontrib><creatorcontrib>Healy, Helen G.</creatorcontrib><creatorcontrib>Lee, Jeremy</creatorcontrib><creatorcontrib>Tan, Ken-Soon</creatorcontrib><creatorcontrib>Venuthurupalli, Sree</creatorcontrib><creatorcontrib>Zhang, Jianzhen</creatorcontrib><creatorcontrib>Hoy, Wendy E.</creatorcontrib><creatorcontrib>NHMRC CKD.CRE, the CKD.QLD Collaborative</creatorcontrib><creatorcontrib>the NHMRC CKD.CRE, the CKD.QLD Collaborative</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellis, Robert J.</au><au>Cameron, Anne</au><au>Gobe, Glenda C.</au><au>Diwan, Vishal</au><au>Healy, Helen G.</au><au>Lee, Jeremy</au><au>Tan, Ken-Soon</au><au>Venuthurupalli, Sree</au><au>Zhang, Jianzhen</au><au>Hoy, Wendy E.</au><aucorp>NHMRC CKD.CRE, the CKD.QLD Collaborative</aucorp><aucorp>the NHMRC CKD.CRE, the CKD.QLD Collaborative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney failure, CKD progression and mortality after nephrectomy</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>54</volume><issue>9</issue><spage>2239</spage><epage>2245</epage><pages>2239-2245</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Purpose
This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.
Methods
A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.
Results
Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR < 45 mL/min per 1.73m
2
at recruitment, patients with diabetic nephropathy and PCKD had the highest rates (per 1000 person-years) of kidney failure (107.8, 95% CI 71.0–163.8; 75.5, 95% CI 65.6–87.1); whereas, patients with glomerulonephritis and an acquired single kidney had lower rates (52.9, 95% CI 38.8–72.1; 34.6, 95% CI 20.5–58.4, respectively). Among patients with an eGFR ≥ 45 mL/min per 1.73m
2
, those with diabetic nephropathy had the highest rates of kidney failure (16.6, 95% CI 92.5–117.3); whereas, those with glomerulonephritis, PCKD and acquired single kidney had a lower risk (11.3, 95% CI 7.1–17.9; 11.7, 95% CI 3.8–36.2; 10.7, 95% CI 4.0–28.4, respectively).
Conclusion
Patients who developed CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes. While CKD after nephrectomy is not the most aggressive cause of kidney disease, it is by no means benign, and is associated with a tangible risk of kidney failure and death, which is comparable to other major causes of CKD.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>35084650</pmid><doi>10.1007/s11255-022-03114-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9755-9913</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Diabetes Diabetes mellitus Diabetic nephropathy Epidermal growth factor receptors Glomerulonephritis Kidney diseases Medicine Medicine & Public Health Nephrectomy Nephrology Nephrology - Original Paper Nephropathy Renal failure Urology |
| title | Kidney failure, CKD progression and mortality after nephrectomy |
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