Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy?
The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative...
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| Veröffentlicht in: | International journal of molecular sciences 2022-08, Vol.23 (15), p.8395 |
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| creator | Morand, Grégoire B. Cardona, Isabel Cruz, Sara Brito Silva Costa Mlynarek, Alex M. Hier, Michael P. Alaoui-Jamali, Moulay A. da Silva, Sabrina Daniela |
| description | The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic. |
| doi_str_mv | 10.3390/ijms23158395 |
| format | Article |
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| subjects | Alcohol Antibodies Binding sites Cell cycle Cervical cancer Cervix Chemical compounds Clinical trials Enzymes Epidemiology Gene expression Genomes Head & neck cancer Human papillomavirus Infections Pathogenesis Patients Pharmacology Proteins Quality of life Review Smoking Squamous cell carcinoma Strategy Throat cancer Toxicity Tumors Vaccines Viruses |
| title | Therapeutic Vaccines for HPV-Associated Oropharyngeal and Cervical Cancer: The Next De-Intensification Strategy? |
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