The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus
Primary Malignant Melanoma of the Esophagus (PMME) is an extremely rare cancer of the esophagus, accounting for 0.1−0.8% of all oro-esophageal cancers and
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| Veröffentlicht in: | Cancers 2022-07, Vol.14 (15), p.3725 |
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| creator | Cazzato, Gerardo Cascardi, Eliano Colagrande, Anna Lettini, Teresa Resta, Leonardo Bizzoca, Cinzia Arezzo, Francesca Loizzi, Vera Dellino, Miriam Cormio, Gennaro Casatta, Nadia Lupo, Carmelo Scillimati, Antonio Scacco, Salvatore Parente, Paola Lospalluti, Lucia Ingravallo, Giuseppe |
| description | Primary Malignant Melanoma of the Esophagus (PMME) is an extremely rare cancer of the esophagus, accounting for 0.1−0.8% of all oro-esophageal cancers and |
| doi_str_mv | 10.3390/cancers14153725 |
| format | Article |
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We conduct a careful analysis of the literature starting from 1906 to the beginning of 2022, searching the PubMed, Science.gov, Scopus and Web of Science (WoS) databases. A total of 457 records were initially identified in the literature search, of which 17 were duplicates. After screening for eligibility and inclusion criteria, 303 publications were ultimately included, related to 347 patients with PMME. PMME represents a very rare entity whose very existence has been the subject of debate for a long time. Over time, an increasing number of cases have been reported in the literature, leading to an increase in knowledge and laying the foundations for a discussion on the treatment of this pathology, which still remains largely represented by surgery. In recent times, the possibility of discovering greater mutations in gene hotspots has made it possible to develop new therapeutic strategies of which nivolumab is an example. Future studies with large case series, with clinicopathological and molecular data, will be necessary to improve the outcome of patients with PMME.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14153725</identifier><identifier>PMID: 35954389</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Autopsy ; Esophagus ; Immunotherapy ; Medical prognosis ; Melanoma ; Patients ; Skin cancer ; Systematic Review ; Tumors</subject><ispartof>Cancers, 2022-07, Vol.14 (15), p.3725</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Future studies with large case series, with clinicopathological and molecular data, will be necessary to improve the outcome of patients with PMME.</description><subject>Autopsy</subject><subject>Esophagus</subject><subject>Immunotherapy</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Patients</subject><subject>Skin cancer</subject><subject>Systematic Review</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1rGzEQxUVoiIPjc25hIZdeXEsafW0OhWCStpDQ0voutNpZe83uyl3tpuS_r4wTk4bqMoL5zWPePEIuGf0EkNOFd53HPjLBJGguT8g5p5rPlcrFhzf_CZnFuKXpATCt9BmZgMylAJOfk91qg9lqE8boujK7dx5jFqrs0TX1unPdkD1i47rQupvsNvv1HAds3VD77Cc-1fhnjw5J4Edft65__s_YK3EXw27j1mO8IKeVayLOXuqUrO7vVsuv84fvX74tbx_mXhg9zCsFnHpdFQUFKQTjJYBkBdMGClU6k0snSgRILoSEEgwFoQwWtDSFwgqm5PNBdjcWLZYeu6F3jd0dFrXB1fbfTldv7Do82RyUlkYmgY8vAn34PWIcbFtHj02yhelalmvKWc4N1wm9foduw9h3yd2eohIYVSxRiwPl-xBjj9VxGUbtPk_7Ls80cfXWw5F_TQ_-AnO3nNA</recordid><startdate>20220730</startdate><enddate>20220730</enddate><creator>Cazzato, Gerardo</creator><creator>Cascardi, Eliano</creator><creator>Colagrande, Anna</creator><creator>Lettini, Teresa</creator><creator>Resta, Leonardo</creator><creator>Bizzoca, Cinzia</creator><creator>Arezzo, Francesca</creator><creator>Loizzi, Vera</creator><creator>Dellino, Miriam</creator><creator>Cormio, Gennaro</creator><creator>Casatta, Nadia</creator><creator>Lupo, Carmelo</creator><creator>Scillimati, Antonio</creator><creator>Scacco, Salvatore</creator><creator>Parente, Paola</creator><creator>Lospalluti, Lucia</creator><creator>Ingravallo, Giuseppe</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5745-372X</orcidid><orcidid>https://orcid.org/0000-0003-4335-4776</orcidid><orcidid>https://orcid.org/0000-0003-0591-6723</orcidid><orcidid>https://orcid.org/0000-0002-4792-3545</orcidid><orcidid>https://orcid.org/0000-0003-2717-2489</orcidid><orcidid>https://orcid.org/0000-0003-3522-4648</orcidid><orcidid>https://orcid.org/0000-0003-1287-4285</orcidid><orcidid>https://orcid.org/0000-0002-4006-6421</orcidid><orcidid>https://orcid.org/0000-0003-0325-4316</orcidid><orcidid>https://orcid.org/0000-0002-4861-0727</orcidid><orcidid>https://orcid.org/0000-0003-4676-0761</orcidid></search><sort><creationdate>20220730</creationdate><title>The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus</title><author>Cazzato, Gerardo ; 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| ispartof | Cancers, 2022-07, Vol.14 (15), p.3725 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Autopsy Esophagus Immunotherapy Medical prognosis Melanoma Patients Skin cancer Systematic Review Tumors |
| title | The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus |
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