Serial Analysis of Gene Mutations and Gene Expression during First-Line Chemotherapy against Metastatic Colorectal Cancer: Identification of Potentially Actionable Targets within the Multicenter Prospective Biomarker Study REVEAL

Most metastatic colorectal cancer (mCRC) patients succumb to refractory disease due to secondary chemotherapy resistance. To elucidate the molecular changes associated with secondary resistance, we recruited 64 patients with mCRC and hepatic metastases before standard first-line chemotherapy between...

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Veröffentlicht in:	Cancers 2022-07, Vol.14 (15), p.3631
Hauptverfasser:	Kumbrink, Jörg, Bohlmann, Lisa, Mamlouk, Soulafa, Redmer, Torben, Peilstöcker, Daniela, Li, Pan, Lorenzen, Sylvie, Algül, Hana, Kasper, Stefan, Hempel, Dirk, Kaiser, Florian, Michl, Marlies, Bartsch, Harald, Neumann, Jens, Klauschen, Frederick, von Bergwelt-Baildon, Michael, Modest, Dominik, Stahler, Arndt, Stintzing, Sebastian, Jung, Andreas, Kirchner, Thomas, Schäfer, Reinhold, Heinemann, Volker, Holch, Julian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Autophagy Bioinformatics Biomarkers Biopsy Blood Cancer therapies Chemoresistance Chemotherapy Colorectal cancer Colorectal carcinoma Gene expression Genomes Genomics Growth factors Liver Metastases Metastasis Mortality Mutation Next-generation sequencing p53 Protein Patients Statistical analysis Tumors
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