Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia
Objective. The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE). Methods. Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were inclu...
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| creator | Yang, Weina Yang, Xuemei Zhang, Su’e Zhang, Limei Wang, Wenze Wang, Li |
| description | Objective. The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE). Methods. Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were included in the control group. The serum levels of CCL21 and Hsp90 were compared between the two groups. Results. PE patients showed significantly higher levels of CCL21 and Hsp90 than healthy pregnant women P 0, P1, P |
| doi_str_mv | 10.1155/2022/2156424 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9365573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2701959987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-37bf9496de4bad0f64a61049ce3a34bd753d7a5d09cc4cd8b8661d659dede4f63</originalsourceid><addsrcrecordid>eNp9kc1rFTEUxYMo9kN3riXgplLH5juTjSCDtoUnClVwFzNJppN2JnkmMy39753Hez7Uhat7L_d3D_dwAHiB0VuMOT8jiJAzgrlghD0Ch1gyXDFS14_3vfx-AI5KuUGIKCnlU3BAuRJCEnEIfjQpZz-YKaQIUwevfJ5H2PR-TLchenjSVA38lKbQvYarcG2igwTDTbnwZoJXfbK38EtOkw8RKgTvw9Qvs_d2MOO6BPMMPOnMUPzzXT0G3z5--NpcVKvP55fN-1VlGaunisq2U0wJ51lrHOoEMwIjpqynhrLWSU6dNNwhZS2zrm5rIbATXDm_nHSCHoN3W9313I7eWR-nbAa9zmE0-UEnE_Tfmxh6fZ3utKKCc0kXgZOdQE4_Z18mPYZi_TCY6NNcNJGIsJrWnCzoq3_QmzTnuNjbUFhxpWq5UG-2lM2plOy7_TMY6U10ehOd3kW34C__NLCHf2e1AKdboA_Rmfvwf7lfyImfsw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2701959987</pqid></control><display><type>article</type><title>Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yang, Weina ; Yang, Xuemei ; Zhang, Su’e ; Zhang, Limei ; Wang, Wenze ; Wang, Li</creator><contributor>Wang, Tian Jiao ; Tian Jiao Wang</contributor><creatorcontrib>Yang, Weina ; Yang, Xuemei ; Zhang, Su’e ; Zhang, Limei ; Wang, Wenze ; Wang, Li ; Wang, Tian Jiao ; Tian Jiao Wang</creatorcontrib><description>Objective. The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE). Methods. Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were included in the control group. The serum levels of CCL21 and Hsp90 were compared between the two groups. Results. PE patients showed significantly higher levels of CCL21 and Hsp90 than healthy pregnant women P<0.05. Correlation analysis showed a positive correlation between CCL21 and Hsp90 levels (r > 0, P<0.05). Binary logistic regression analysis suggested that high expression of CCL21 and Hsp90 were influencing factors for PE (OR >1, P<0.05). The area under the receiver operating characteristic (AUC) curves of Hsp90 and CCL21 levels for predicting PE were 0.895 and 0.864, respectively, suggesting a good predictive value. Conclusion. Serum CCL21 and Hsp90 show great potential as disease markers for PE prediction. Further trials are, however, required prior to clinical promotion.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/2156424</identifier><identifier>PMID: 35966726</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Blood pressure ; Cardiovascular disease ; CCL21 protein ; Chemokines ; Chinese medicine ; Clinical trials ; Correlation analysis ; Edema ; Enzymes ; Heat shock proteins ; Hsp90 protein ; Hypertension ; Ligands ; Liver ; Patients ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Regression analysis ; Serum levels ; Smooth muscle ; Womens health</subject><ispartof>Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.2156424-5</ispartof><rights>Copyright © 2022 Weina Yang et al.</rights><rights>Copyright © 2022 Weina Yang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Weina Yang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-37bf9496de4bad0f64a61049ce3a34bd753d7a5d09cc4cd8b8661d659dede4f63</citedby><cites>FETCH-LOGICAL-c448t-37bf9496de4bad0f64a61049ce3a34bd753d7a5d09cc4cd8b8661d659dede4f63</cites><orcidid>0000-0001-5676-5027</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365573/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365573/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35966726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Tian Jiao</contributor><contributor>Tian Jiao Wang</contributor><creatorcontrib>Yang, Weina</creatorcontrib><creatorcontrib>Yang, Xuemei</creatorcontrib><creatorcontrib>Zhang, Su’e</creatorcontrib><creatorcontrib>Zhang, Limei</creatorcontrib><creatorcontrib>Wang, Wenze</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><title>Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Objective. The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE). Methods. Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were included in the control group. The serum levels of CCL21 and Hsp90 were compared between the two groups. Results. PE patients showed significantly higher levels of CCL21 and Hsp90 than healthy pregnant women P<0.05. Correlation analysis showed a positive correlation between CCL21 and Hsp90 levels (r > 0, P<0.05). Binary logistic regression analysis suggested that high expression of CCL21 and Hsp90 were influencing factors for PE (OR >1, P<0.05). The area under the receiver operating characteristic (AUC) curves of Hsp90 and CCL21 levels for predicting PE were 0.895 and 0.864, respectively, suggesting a good predictive value. Conclusion. Serum CCL21 and Hsp90 show great potential as disease markers for PE prediction. Further trials are, however, required prior to clinical promotion.</description><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>CCL21 protein</subject><subject>Chemokines</subject><subject>Chinese medicine</subject><subject>Clinical trials</subject><subject>Correlation analysis</subject><subject>Edema</subject><subject>Enzymes</subject><subject>Heat shock proteins</subject><subject>Hsp90 protein</subject><subject>Hypertension</subject><subject>Ligands</subject><subject>Liver</subject><subject>Patients</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Serum levels</subject><subject>Smooth muscle</subject><subject>Womens health</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1rFTEUxYMo9kN3riXgplLH5juTjSCDtoUnClVwFzNJppN2JnkmMy39753Hez7Uhat7L_d3D_dwAHiB0VuMOT8jiJAzgrlghD0Ch1gyXDFS14_3vfx-AI5KuUGIKCnlU3BAuRJCEnEIfjQpZz-YKaQIUwevfJ5H2PR-TLchenjSVA38lKbQvYarcG2igwTDTbnwZoJXfbK38EtOkw8RKgTvw9Qvs_d2MOO6BPMMPOnMUPzzXT0G3z5--NpcVKvP55fN-1VlGaunisq2U0wJ51lrHOoEMwIjpqynhrLWSU6dNNwhZS2zrm5rIbATXDm_nHSCHoN3W9313I7eWR-nbAa9zmE0-UEnE_Tfmxh6fZ3utKKCc0kXgZOdQE4_Z18mPYZi_TCY6NNcNJGIsJrWnCzoq3_QmzTnuNjbUFhxpWq5UG-2lM2plOy7_TMY6U10ehOd3kW34C__NLCHf2e1AKdboA_Rmfvwf7lfyImfsw</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Yang, Weina</creator><creator>Yang, Xuemei</creator><creator>Zhang, Su’e</creator><creator>Zhang, Limei</creator><creator>Wang, Wenze</creator><creator>Wang, Li</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5676-5027</orcidid></search><sort><creationdate>2022</creationdate><title>Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia</title><author>Yang, Weina ; Yang, Xuemei ; Zhang, Su’e ; Zhang, Limei ; Wang, Wenze ; Wang, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-37bf9496de4bad0f64a61049ce3a34bd753d7a5d09cc4cd8b8661d659dede4f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>CCL21 protein</topic><topic>Chemokines</topic><topic>Chinese medicine</topic><topic>Clinical trials</topic><topic>Correlation analysis</topic><topic>Edema</topic><topic>Enzymes</topic><topic>Heat shock proteins</topic><topic>Hsp90 protein</topic><topic>Hypertension</topic><topic>Ligands</topic><topic>Liver</topic><topic>Patients</topic><topic>Pre-eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Regression analysis</topic><topic>Serum levels</topic><topic>Smooth muscle</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Weina</creatorcontrib><creatorcontrib>Yang, Xuemei</creatorcontrib><creatorcontrib>Zhang, Su’e</creatorcontrib><creatorcontrib>Zhang, Limei</creatorcontrib><creatorcontrib>Wang, Wenze</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Weina</au><au>Yang, Xuemei</au><au>Zhang, Su’e</au><au>Zhang, Limei</au><au>Wang, Wenze</au><au>Wang, Li</au><au>Wang, Tian Jiao</au><au>Tian Jiao Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>2156424</spage><epage>5</epage><pages>2156424-5</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Objective. The study aimed to explore the correlation of serum chemokine (C-C motif) ligand 21 (CCL21) and heat shock protein 90 (Hsp90) with preeclampsia (PE). Methods. Between June 2021 and June 2022, 50 pregnant women with PE were included in the PE group, and 50 healthy pregnant women were included in the control group. The serum levels of CCL21 and Hsp90 were compared between the two groups. Results. PE patients showed significantly higher levels of CCL21 and Hsp90 than healthy pregnant women P<0.05. Correlation analysis showed a positive correlation between CCL21 and Hsp90 levels (r > 0, P<0.05). Binary logistic regression analysis suggested that high expression of CCL21 and Hsp90 were influencing factors for PE (OR >1, P<0.05). The area under the receiver operating characteristic (AUC) curves of Hsp90 and CCL21 levels for predicting PE were 0.895 and 0.864, respectively, suggesting a good predictive value. Conclusion. Serum CCL21 and Hsp90 show great potential as disease markers for PE prediction. Further trials are, however, required prior to clinical promotion.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35966726</pmid><doi>10.1155/2022/2156424</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-5676-5027</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Blood pressure Cardiovascular disease CCL21 protein Chemokines Chinese medicine Clinical trials Correlation analysis Edema Enzymes Heat shock proteins Hsp90 protein Hypertension Ligands Liver Patients Pre-eclampsia Preeclampsia Pregnancy Regression analysis Serum levels Smooth muscle Womens health |
| title | Correlation of Serum Chemokine (C-C Motif) Ligand 21 and Heat Shock Protein 90 with Preeclampsia |
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