Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti-PD-1 Therapy

Transcriptomic profiling was performed for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal tumors to determine the predictors of response to PD-1 blockade. Thirty-six patients with MSI-H/dMMR gastrointestinal tumors, including gastric cancer, colorectal canc...

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Veröffentlicht in:	Clinical cancer research 2022-05, Vol.28 (10), p.2110-2117
Hauptverfasser:	Chida, Keigo, Kawazoe, Akihito, Suzuki, Toshihiro, Kawazu, Masahito, Ueno, Toshihide, Takenouchi, Kazumasa, Nakamura, Yoshiaki, Kuboki, Yasutoshi, Kotani, Daisuke, Kojima, Takashi, Bando, Hideaki, Mishima, Saori, Kuwata, Takeshi, Sakamoto, Naoya, Watanabe, Jun, Mano, Hiroyuki, Ikeda, Masafumi, Shitara, Kohei, Endo, Itaru, Nakatsura, Tetsuya, Yoshino, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA Mismatch Repair Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - genetics Humans Microsatellite Instability Mutation Programmed Cell Death 1 Receptor - genetics Transcriptome Translational Cancer Mechanisms and Therapy Vascular Endothelial Growth Factor A - genetics
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