A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer

DNA-dependent protein kinase catalytic subunit (DNA-PKcs, herein referred as DNA-PK) is a multifunctional kinase of high cancer relevance. DNA-PK is deregulated in multiple tumor types, including prostate cancer, and is associated with poor outcomes. DNA-PK was previously nominated as a therapeutic...

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Veröffentlicht in:	Clinical cancer research 2022-04, Vol.28 (7), p.1446-1459
Hauptverfasser:	Dylgjeri, Emanuela, Kothari, Vishal, Shafi, Ayesha A, Semenova, Galina, Gallagher, Peter T, Guan, Yi F, Pang, Angel, Goodwin, Jonathan F, Irani, Swati, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati, McNair, Christopher M, Vasilevskaya, Irina, Schiewer, Matthew J, Lallas, Costas D, McCue, Peter A, Gomella, Leonard G, Seifert, Erin L, Carroll, Jason S, Butler, Lisa M, Holst, Jeff, Kelly, William K, Knudsen, Karen E
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism Glycolysis Humans Male Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Proteomics Pyruvate Kinase - metabolism Translational Cancer Mechanisms and Therapy
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