Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice
Ulcerative colitis (UC) is difficult to eradicate as it leads to chronic inflammation in the digestive tract due to immune system malfunction. The present study demonstrated the protective effect of 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid (diHEP-DPA), which had been previously synthesiz...
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| Veröffentlicht in: | Molecular medicine reports 2022-09, Vol.26 (3), Article 278 |
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| creator | Wang, Lifang Choi, Hack Sun Su, Yan Lee, Binna Choi, Jong Hyun Jang, Sun-Hee Jang, Yong-Suk Seo, JeongWoo |
| description | Ulcerative colitis (UC) is difficult to eradicate as it leads to chronic inflammation in the digestive tract due to immune system malfunction. The present study demonstrated the protective effect of 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid (diHEP-DPA), which had been previously synthesized, on a dextran sulfate sodium (DSS)-induced BALB/c mouse model of UC. UC was induced with 4% DSS drinking water for 7 days. Initially, the anti-inflammatory effect of diHEP-DPA was confirmed by demonstrating that lipopolysaccharide-stimulated THP1 cells treated with diHEP-DPA decreased IL-6, TNF-[alpha] and nitrite levels by fluorescence-activated cell sorting (FACS) and Griess reagent kit. The results indicated that the administration of diHEP-DPA at 20 [micro]g/kg significantly reduced the severity of colitis, as determined by hematoxylin and eosin staining. The levels of TNF-[alpha], IL-6 and IL-1[beta] in the colon tissue and serum were significantly reduced in the diHEP-DPA + DSS-treated group compared with in the control group, as determined by FACS and ELISA kit. It was also observed that diHEP-DPA decreased myeloperoxidase (MPO) and nitrite levels in the colon tissues of diHEP-DPA + DSS-treated mice, as indicated using commercial MPO and nitric oxide kits. The diHEP-DPA+DSS-treated mice also exhibited decreased expression levels of phosporylated (p)-inhibitor k B protein, p-p65 and inducible nitric oxide synthase in the colon tissue by inhibiting inflammation, which were measured by reverse transcription-quantitative PCR and weatern blot analysis. Overall, the present study demonstrated the protective effect of diHEP-DPA against a severe colitis condition in vivo. Key words: 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid, dextran sulfate sodium, ulcerative colitis, inflammation, NF-[kappa]B pathway |
| doi_str_mv | 10.3892/mmr.2022.12794 |
| format | Article |
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The present study demonstrated the protective effect of 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid (diHEP-DPA), which had been previously synthesized, on a dextran sulfate sodium (DSS)-induced BALB/c mouse model of UC. UC was induced with 4% DSS drinking water for 7 days. Initially, the anti-inflammatory effect of diHEP-DPA was confirmed by demonstrating that lipopolysaccharide-stimulated THP1 cells treated with diHEP-DPA decreased IL-6, TNF-[alpha] and nitrite levels by fluorescence-activated cell sorting (FACS) and Griess reagent kit. The results indicated that the administration of diHEP-DPA at 20 [micro]g/kg significantly reduced the severity of colitis, as determined by hematoxylin and eosin staining. The levels of TNF-[alpha], IL-6 and IL-1[beta] in the colon tissue and serum were significantly reduced in the diHEP-DPA + DSS-treated group compared with in the control group, as determined by FACS and ELISA kit. It was also observed that diHEP-DPA decreased myeloperoxidase (MPO) and nitrite levels in the colon tissues of diHEP-DPA + DSS-treated mice, as indicated using commercial MPO and nitric oxide kits. The diHEP-DPA+DSS-treated mice also exhibited decreased expression levels of phosporylated (p)-inhibitor k B protein, p-p65 and inducible nitric oxide synthase in the colon tissue by inhibiting inflammation, which were measured by reverse transcription-quantitative PCR and weatern blot analysis. Overall, the present study demonstrated the protective effect of diHEP-DPA against a severe colitis condition in vivo. Key words: 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid, dextran sulfate sodium, ulcerative colitis, inflammation, NF-[kappa]B pathway</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2022.12794</identifier><identifier>PMID: 35856414</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Analysis ; Animal models in research ; Animals ; Antibodies ; Care and treatment ; Colon ; Complications and side effects ; Cytokines ; Dextran ; Dextran sulfate ; Diagnosis ; Dosage and administration ; Drinking water ; Experiments ; Flow cytometry ; Gastrointestinal tract ; Gene expression ; IL-1β ; Immune system ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Interleukin 6 ; Lipopolysaccharides ; Neutrophils ; Nitric-oxide synthase ; Omega-3 fatty acids ; Peroxidase ; Reverse transcription ; Risk factors ; Software ; Tumor necrosis factor ; Tumor necrosis factor-α ; Ulcerative colitis</subject><ispartof>Molecular medicine reports, 2022-09, Vol.26 (3), Article 278</ispartof><rights>COPYRIGHT 2022 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2022</rights><rights>Copyright: © Wang et al. 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-269cb0d6fbd6f05f28215a9f32e10910e6ac5595773e594e0c9033600576b1f63</citedby><cites>FETCH-LOGICAL-c462t-269cb0d6fbd6f05f28215a9f32e10910e6ac5595773e594e0c9033600576b1f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Wang, Lifang</creatorcontrib><creatorcontrib>Choi, Hack Sun</creatorcontrib><creatorcontrib>Su, Yan</creatorcontrib><creatorcontrib>Lee, Binna</creatorcontrib><creatorcontrib>Choi, Jong Hyun</creatorcontrib><creatorcontrib>Jang, Sun-Hee</creatorcontrib><creatorcontrib>Jang, Yong-Suk</creatorcontrib><creatorcontrib>Seo, JeongWoo</creatorcontrib><title>Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice</title><title>Molecular medicine reports</title><description>Ulcerative colitis (UC) is difficult to eradicate as it leads to chronic inflammation in the digestive tract due to immune system malfunction. The present study demonstrated the protective effect of 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid (diHEP-DPA), which had been previously synthesized, on a dextran sulfate sodium (DSS)-induced BALB/c mouse model of UC. UC was induced with 4% DSS drinking water for 7 days. Initially, the anti-inflammatory effect of diHEP-DPA was confirmed by demonstrating that lipopolysaccharide-stimulated THP1 cells treated with diHEP-DPA decreased IL-6, TNF-[alpha] and nitrite levels by fluorescence-activated cell sorting (FACS) and Griess reagent kit. The results indicated that the administration of diHEP-DPA at 20 [micro]g/kg significantly reduced the severity of colitis, as determined by hematoxylin and eosin staining. The levels of TNF-[alpha], IL-6 and IL-1[beta] in the colon tissue and serum were significantly reduced in the diHEP-DPA + DSS-treated group compared with in the control group, as determined by FACS and ELISA kit. It was also observed that diHEP-DPA decreased myeloperoxidase (MPO) and nitrite levels in the colon tissues of diHEP-DPA + DSS-treated mice, as indicated using commercial MPO and nitric oxide kits. The diHEP-DPA+DSS-treated mice also exhibited decreased expression levels of phosporylated (p)-inhibitor k B protein, p-p65 and inducible nitric oxide synthase in the colon tissue by inhibiting inflammation, which were measured by reverse transcription-quantitative PCR and weatern blot analysis. Overall, the present study demonstrated the protective effect of diHEP-DPA against a severe colitis condition in vivo. Key words: 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid, dextran sulfate sodium, ulcerative colitis, inflammation, NF-[kappa]B pathway</description><subject>Analysis</subject><subject>Animal models in research</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Care and treatment</subject><subject>Colon</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Dextran</subject><subject>Dextran sulfate</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Drinking water</subject><subject>Experiments</subject><subject>Flow cytometry</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>IL-1β</subject><subject>Immune system</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Interleukin 6</subject><subject>Lipopolysaccharides</subject><subject>Neutrophils</subject><subject>Nitric-oxide synthase</subject><subject>Omega-3 fatty acids</subject><subject>Peroxidase</subject><subject>Reverse transcription</subject><subject>Risk factors</subject><subject>Software</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-α</subject><subject>Ulcerative colitis</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUk1rVDEUfYhia3XrOuDGzUzznclGmJZWhQGF1nXI5N2MKe8lY5JX2p3-hP5Ff4mZdigqJYR7uffk5J7L6bq3BM_ZQtPjccxziimdE6o0f9YdEqXJjGHMn-9zqrU66F6VcoWxFFTol90BEwshOeGH3a-vOVVwNVwDAu9bhpJHRF38_nkH23Rz22KfXCp2C7FaiCk4ZF3okd3YEEtFPdzUbCMq0-BtBVRSH6YRhdhPDno0DQ6yved3aQg1lNZCJ8vVybFDY3Dwunvh7VDgzT4edd_Ozy5PP81WXz5-Pl2uZo5LWmdUarfGvfTrdrHwdEGJsNozCgRrgkFaJ4QWSjEQmgN2GjMmMRZKromX7Kj78MC7ndYj9K7JyXYw2xxGm29NssH824nhu9mka6PZblW8EbzfE-T0Y4JSzRiKg2GwEdJUTJuQYiWJ1g367j_oVZpybPIMVRhrTRn_C7WxA5gQfWr_uh2pWSrCGeULqRpq_gSqnR7a-lIEH1r9qQcup1Iy-EeNBJudaUwzjdmZxtybhv0BwGq1Uw</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Wang, Lifang</creator><creator>Choi, Hack Sun</creator><creator>Su, Yan</creator><creator>Lee, Binna</creator><creator>Choi, Jong Hyun</creator><creator>Jang, Sun-Hee</creator><creator>Jang, Yong-Suk</creator><creator>Seo, JeongWoo</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220901</creationdate><title>Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice</title><author>Wang, Lifang ; Choi, Hack Sun ; Su, Yan ; Lee, Binna ; Choi, Jong Hyun ; Jang, Sun-Hee ; Jang, Yong-Suk ; Seo, JeongWoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-269cb0d6fbd6f05f28215a9f32e10910e6ac5595773e594e0c9033600576b1f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Animal models in research</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Care and treatment</topic><topic>Colon</topic><topic>Complications and side effects</topic><topic>Cytokines</topic><topic>Dextran</topic><topic>Dextran sulfate</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Drinking water</topic><topic>Experiments</topic><topic>Flow cytometry</topic><topic>Gastrointestinal tract</topic><topic>Gene expression</topic><topic>IL-1β</topic><topic>Immune system</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Interleukin 6</topic><topic>Lipopolysaccharides</topic><topic>Neutrophils</topic><topic>Nitric-oxide synthase</topic><topic>Omega-3 fatty acids</topic><topic>Peroxidase</topic><topic>Reverse transcription</topic><topic>Risk factors</topic><topic>Software</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-α</topic><topic>Ulcerative colitis</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lifang</creatorcontrib><creatorcontrib>Choi, Hack Sun</creatorcontrib><creatorcontrib>Su, Yan</creatorcontrib><creatorcontrib>Lee, Binna</creatorcontrib><creatorcontrib>Choi, Jong Hyun</creatorcontrib><creatorcontrib>Jang, Sun-Hee</creatorcontrib><creatorcontrib>Jang, Yong-Suk</creatorcontrib><creatorcontrib>Seo, JeongWoo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lifang</au><au>Choi, Hack Sun</au><au>Su, Yan</au><au>Lee, Binna</au><au>Choi, Jong Hyun</au><au>Jang, Sun-Hee</au><au>Jang, Yong-Suk</au><au>Seo, JeongWoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice</atitle><jtitle>Molecular medicine reports</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>26</volume><issue>3</issue><artnum>278</artnum><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Ulcerative colitis (UC) is difficult to eradicate as it leads to chronic inflammation in the digestive tract due to immune system malfunction. The present study demonstrated the protective effect of 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid (diHEP-DPA), which had been previously synthesized, on a dextran sulfate sodium (DSS)-induced BALB/c mouse model of UC. UC was induced with 4% DSS drinking water for 7 days. Initially, the anti-inflammatory effect of diHEP-DPA was confirmed by demonstrating that lipopolysaccharide-stimulated THP1 cells treated with diHEP-DPA decreased IL-6, TNF-[alpha] and nitrite levels by fluorescence-activated cell sorting (FACS) and Griess reagent kit. The results indicated that the administration of diHEP-DPA at 20 [micro]g/kg significantly reduced the severity of colitis, as determined by hematoxylin and eosin staining. The levels of TNF-[alpha], IL-6 and IL-1[beta] in the colon tissue and serum were significantly reduced in the diHEP-DPA + DSS-treated group compared with in the control group, as determined by FACS and ELISA kit. It was also observed that diHEP-DPA decreased myeloperoxidase (MPO) and nitrite levels in the colon tissues of diHEP-DPA + DSS-treated mice, as indicated using commercial MPO and nitric oxide kits. The diHEP-DPA+DSS-treated mice also exhibited decreased expression levels of phosporylated (p)-inhibitor k B protein, p-p65 and inducible nitric oxide synthase in the colon tissue by inhibiting inflammation, which were measured by reverse transcription-quantitative PCR and weatern blot analysis. Overall, the present study demonstrated the protective effect of diHEP-DPA against a severe colitis condition in vivo. Key words: 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid, dextran sulfate sodium, ulcerative colitis, inflammation, NF-[kappa]B pathway</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>35856414</pmid><doi>10.3892/mmr.2022.12794</doi><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Analysis Animal models in research Animals Antibodies Care and treatment Colon Complications and side effects Cytokines Dextran Dextran sulfate Diagnosis Dosage and administration Drinking water Experiments Flow cytometry Gastrointestinal tract Gene expression IL-1β Immune system Inflammatory bowel disease Inflammatory bowel diseases Interleukin 6 Lipopolysaccharides Neutrophils Nitric-oxide synthase Omega-3 fatty acids Peroxidase Reverse transcription Risk factors Software Tumor necrosis factor Tumor necrosis factor-α Ulcerative colitis |
| title | Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice |
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