Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation

Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase deficiency and heparan sulfate storage on energy homeostasis and metabol...

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Veröffentlicht in:	The Journal of biological chemistry 2022-08, Vol.298 (8), p.102159-102159, Article 102159
Hauptverfasser:	Tillo, Miguel, Lamanna, William C., Dwyer, Chrissa A., Sandoval, Daniel R., Pessentheiner, Ariane R., Al-Azzam, Norah, Sarrazin, Stéphane, Gonzales, Jon C., Kan, Shih-Hsin, Andreyev, Alexander Y., Schultheis, Nicholas, Thacker, Bryan E., Glass, Charles A., Dickson, Patricia I., Wang, Raymond Y., Selleck, Scott B., Esko, Jeffrey D., Gordts, Philip L.S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - metabolism Animals autophagy Cachexia dyslipidemia hyperthermia Hypertriglyceridemia Mice mitochondria Mitophagy mucopolysaccharidoses Mucopolysaccharidosis III - metabolism Mucopolysaccharidosis III - therapy sulfamidase Triolein
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