Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways

The purpose of this study was to investigate the roles of ciliary neurotrophic factor (CNTF) on the protective effects of astrocytes on retinal ganglion cells (RGCs). Primary RGCs were isolated from neonatal rats. Oxidative stress was induced, and the effects of co-culture with astrocytes and CNTF t...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2022-08, Vol.63 (9), p.4
Hauptverfasser:	Lee, Kwanghyun, Choi, Jin-Ok, Hwang, Ahreum, Bae, Hyoung Won, Kim, Chan Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Ciliary Neurotrophic Factor - metabolism Ciliary Neurotrophic Factor - pharmacology Extracellular Signal-Regulated MAP Kinases Janus Kinases - metabolism MAP Kinase Signaling System Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Retinal Cell Biology Retinal Ganglion Cells - metabolism Signal Transduction - physiology STAT Transcription Factors Tubulin - metabolism
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