Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outc...
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| Veröffentlicht in: | Cancer and metastasis reviews 2022-06, Vol.41 (2), p.281-299 |
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| creator | Sharma, Tarang Gupta, Ashna Chauhan, Ravi Bhat, Ajaz A. Nisar, Sabah Hashem, Sheema Akhtar, Sabah Ahmad, Aamir Haris, Mohammad Singh, Mayank Uddin, Shahab |
| description | Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention. |
| doi_str_mv | 10.1007/s10555-022-10026-6 |
| format | Article |
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It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention.</description><identifier>ISSN: 0167-7659</identifier><identifier>EISSN: 1573-7233</identifier><identifier>DOI: 10.1007/s10555-022-10026-6</identifier><identifier>PMID: 35511379</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Carcinogenesis ; Chemotherapy ; Development and progression ; Esophageal cancer ; Esophagus ; Health aspects ; Inflammation ; Malignancy ; Medical prognosis ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Molecular modelling ; Oncology ; Oncology, Experimental ; Prognosis ; Radiation therapy ; Radiotherapy ; Squamous cell carcinoma ; Tumor microenvironment ; Tumorigenesis</subject><ispartof>Cancer and metastasis reviews, 2022-06, Vol.41 (2), p.281-299</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Carcinogenesis</subject><subject>Chemotherapy</subject><subject>Development and progression</subject><subject>Esophageal cancer</subject><subject>Esophagus</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Malignancy</subject><subject>Medical prognosis</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Molecular modelling</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Squamous cell carcinoma</subject><subject>Tumor microenvironment</subject><subject>Tumorigenesis</subject><issn>0167-7659</issn><issn>1573-7233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ksluFDEQhi0EIkPgBTggCy5cOnhpbxwiRSM2KRIXOFtud_WMQ7fdsXuCeHs8TMiCIuSD7fJXv13lH6GXlJxQQtS7QokQoiGMNXXPZCMfoRUVijeKcf4YrQiVqlFSmCP0rJQLUpO4Mk_REReC0rpcoXmdUynN4sYfuIPlJ0DEyxbwFHxOXUgTYBd77Lc5xeBxiMPopsktIcW6wVDSvHUbcCP2LnrI7_GcFohLqJE-hyvIOA04RZ82EKGE8hw9GdxY4MX1fIy-f_zwbf25Of_66cv67LzxQuql4Vq3ojftYIzwptfUd1oZpTpBOydax0jPCPSEaWi59EqYymo2EE9aAQL4MTo96M67boLe1zdlN9o5h8nlXza5YO-fxLC1m3RlDZecG1oF3l4L5HS5g7LYKRQP4-gipF2xTEpS295KVtE3_6AXaZdjLc8yRQgVVHN9S23cCLZ2MtV7_V7UninKWasl3V_7-gHKz-HS3oVOHoDq6KF-XIowhBq_p8oOCX7_3RmGm0ZQYvdmsgcz2Wom-8dMVtakV3dbeJPy1z0V4Aeg1KO4gXxb939kfwMGd9OG</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Sharma, Tarang</creator><creator>Gupta, Ashna</creator><creator>Chauhan, Ravi</creator><creator>Bhat, Ajaz A.</creator><creator>Nisar, Sabah</creator><creator>Hashem, Sheema</creator><creator>Akhtar, Sabah</creator><creator>Ahmad, Aamir</creator><creator>Haris, Mohammad</creator><creator>Singh, Mayank</creator><creator>Uddin, Shahab</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M3G</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1886-6710</orcidid></search><sort><creationdate>20220601</creationdate><title>Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis</title><author>Sharma, Tarang ; Gupta, Ashna ; Chauhan, Ravi ; Bhat, Ajaz A. ; Nisar, Sabah ; Hashem, Sheema ; Akhtar, Sabah ; Ahmad, Aamir ; Haris, Mohammad ; Singh, Mayank ; Uddin, Shahab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-38845d94f995c9d81cb87977b51ba54a20d20ed028e436c75994f82f0c045e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Carcinogenesis</topic><topic>Chemotherapy</topic><topic>Development and progression</topic><topic>Esophageal cancer</topic><topic>Esophagus</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Malignancy</topic><topic>Medical prognosis</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Molecular modelling</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Radiotherapy</topic><topic>Squamous cell carcinoma</topic><topic>Tumor microenvironment</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Tarang</creatorcontrib><creatorcontrib>Gupta, Ashna</creatorcontrib><creatorcontrib>Chauhan, Ravi</creatorcontrib><creatorcontrib>Bhat, Ajaz A.</creatorcontrib><creatorcontrib>Nisar, Sabah</creatorcontrib><creatorcontrib>Hashem, Sheema</creatorcontrib><creatorcontrib>Akhtar, Sabah</creatorcontrib><creatorcontrib>Ahmad, Aamir</creatorcontrib><creatorcontrib>Haris, Mohammad</creatorcontrib><creatorcontrib>Singh, Mayank</creatorcontrib><creatorcontrib>Uddin, Shahab</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>CBCA Reference & Current Events</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer and metastasis reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Tarang</au><au>Gupta, Ashna</au><au>Chauhan, Ravi</au><au>Bhat, Ajaz A.</au><au>Nisar, Sabah</au><au>Hashem, Sheema</au><au>Akhtar, Sabah</au><au>Ahmad, Aamir</au><au>Haris, Mohammad</au><au>Singh, Mayank</au><au>Uddin, Shahab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis</atitle><jtitle>Cancer and metastasis reviews</jtitle><stitle>Cancer Metastasis Rev</stitle><addtitle>Cancer Metastasis Rev</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>41</volume><issue>2</issue><spage>281</spage><epage>299</epage><pages>281-299</pages><issn>0167-7659</issn><eissn>1573-7233</eissn><abstract>Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. 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| subjects | Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinogenesis Chemotherapy Development and progression Esophageal cancer Esophagus Health aspects Inflammation Malignancy Medical prognosis Microbiomes Microbiota Microbiota (Symbiotic organisms) Molecular modelling Oncology Oncology, Experimental Prognosis Radiation therapy Radiotherapy Squamous cell carcinoma Tumor microenvironment Tumorigenesis |
| title | Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis |
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