The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals
Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300...
Gespeichert in:
| Veröffentlicht in: | The pharmacogenomics journal 2022-07, Vol.22 (4), p.247-249 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 4 |
| container_start_page | 247 |
| container_title | The pharmacogenomics journal |
| container_volume | 22 |
| creator | Haeggström, Sigrid Ingelman-Sundberg, Magnus Pääbo, Svante Zeberg, Hugo |
| description | Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes
CYP2C8
and
CYP2C9
on chromosome 10 exhibits linkage disequilibrium between the
CYP2C8*3
and
CYP2C9*2
alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals. |
| doi_str_mv | 10.1038/s41397-022-00284-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9363273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2684097544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-28bba706b6c6531ef65ee74eeabf421f0f029c5c8adc0c7f276d9144b2d4a1123</originalsourceid><addsrcrecordid>eNp9kU1rHSEUhqW0NGnaP9CV0E030-jRUWdTKJf0A0JaaArJShznTK7B69zq3MD99zGZkNIssjoHfN4H9SXkPWefOBPmuEguOt0wgIYxMLJRL8ghl1o0nLfs5f3OGlDdxQF5U8o1Y1xxbV6TA9Fqw3jHD8nv8zVSH0MK3sW4pxkj3rg009XlL1gZQV0alr0DunbbOM37LdJQaEhrzGHGgY552tAzrCTm2cXylrwa68B3D_OI_Pl6cr763pz-_PZj9eW08RLauQHT904z1SuvWsFxVC2iloiuHyXwkY0MOt964wbPvB5Bq6HjUvYwSMc5iCPyefFud_0GB49pzi7abQ4bl_d2csH-f5LC2l5NN7YTSoAWVfDxQZCnvzsss92E4jFGl3DaFQvKSNbpVsqKfniCXk-7nOrzLOj6sRrA3AlhoXyeSsk4Pl6GM3vXmV06s7Uze9-ZVTUkllCpcLrC_E_9TOoWHbKXow</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2700172283</pqid></control><display><type>article</type><title>The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals</title><source>Alma/SFX Local Collection</source><creator>Haeggström, Sigrid ; Ingelman-Sundberg, Magnus ; Pääbo, Svante ; Zeberg, Hugo</creator><creatorcontrib>Haeggström, Sigrid ; Ingelman-Sundberg, Magnus ; Pääbo, Svante ; Zeberg, Hugo</creatorcontrib><description>Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes
CYP2C8
and
CYP2C9
on chromosome 10 exhibits linkage disequilibrium between the
CYP2C8*3
and
CYP2C9*2
alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.</description><identifier>ISSN: 1470-269X</identifier><identifier>EISSN: 1473-1150</identifier><identifier>DOI: 10.1038/s41397-022-00284-6</identifier><identifier>PMID: 35780191</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/43 ; 692/499 ; 692/700/155 ; Biomedical and Life Sciences ; Biomedicine ; Chromosome 10 ; Clinical medicine ; Cytochrome ; Cytochrome P450 ; Drug dosages ; Drug metabolism ; Enzymes ; Gene Expression ; Genes ; Genetic diversity ; Genomes ; Haplotypes ; Hominids ; Human Genetics ; Linkage disequilibrium ; Metabolism ; Nonsteroidal anti-inflammatory drugs ; Oncology ; Pharmacotherapy ; Phenytoin ; Population ; Psychopharmacology ; Toxicity</subject><ispartof>The pharmacogenomics journal, 2022-07, Vol.22 (4), p.247-249</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-28bba706b6c6531ef65ee74eeabf421f0f029c5c8adc0c7f276d9144b2d4a1123</citedby><cites>FETCH-LOGICAL-c425t-28bba706b6c6531ef65ee74eeabf421f0f029c5c8adc0c7f276d9144b2d4a1123</cites><orcidid>0000-0002-7255-9079 ; 0000-0001-7118-1249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids></links><search><creatorcontrib>Haeggström, Sigrid</creatorcontrib><creatorcontrib>Ingelman-Sundberg, Magnus</creatorcontrib><creatorcontrib>Pääbo, Svante</creatorcontrib><creatorcontrib>Zeberg, Hugo</creatorcontrib><title>The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals</title><title>The pharmacogenomics journal</title><addtitle>Pharmacogenomics J</addtitle><description>Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes
CYP2C8
and
CYP2C9
on chromosome 10 exhibits linkage disequilibrium between the
CYP2C8*3
and
CYP2C9*2
alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.</description><subject>45/43</subject><subject>692/499</subject><subject>692/700/155</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chromosome 10</subject><subject>Clinical medicine</subject><subject>Cytochrome</subject><subject>Cytochrome P450</subject><subject>Drug dosages</subject><subject>Drug metabolism</subject><subject>Enzymes</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genomes</subject><subject>Haplotypes</subject><subject>Hominids</subject><subject>Human Genetics</subject><subject>Linkage disequilibrium</subject><subject>Metabolism</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oncology</subject><subject>Pharmacotherapy</subject><subject>Phenytoin</subject><subject>Population</subject><subject>Psychopharmacology</subject><subject>Toxicity</subject><issn>1470-269X</issn><issn>1473-1150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1rHSEUhqW0NGnaP9CV0E030-jRUWdTKJf0A0JaaArJShznTK7B69zq3MD99zGZkNIssjoHfN4H9SXkPWefOBPmuEguOt0wgIYxMLJRL8ghl1o0nLfs5f3OGlDdxQF5U8o1Y1xxbV6TA9Fqw3jHD8nv8zVSH0MK3sW4pxkj3rg009XlL1gZQV0alr0DunbbOM37LdJQaEhrzGHGgY552tAzrCTm2cXylrwa68B3D_OI_Pl6cr763pz-_PZj9eW08RLauQHT904z1SuvWsFxVC2iloiuHyXwkY0MOt964wbPvB5Bq6HjUvYwSMc5iCPyefFud_0GB49pzi7abQ4bl_d2csH-f5LC2l5NN7YTSoAWVfDxQZCnvzsss92E4jFGl3DaFQvKSNbpVsqKfniCXk-7nOrzLOj6sRrA3AlhoXyeSsk4Pl6GM3vXmV06s7Uze9-ZVTUkllCpcLrC_E_9TOoWHbKXow</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Haeggström, Sigrid</creator><creator>Ingelman-Sundberg, Magnus</creator><creator>Pääbo, Svante</creator><creator>Zeberg, Hugo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7255-9079</orcidid><orcidid>https://orcid.org/0000-0001-7118-1249</orcidid></search><sort><creationdate>20220701</creationdate><title>The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals</title><author>Haeggström, Sigrid ; Ingelman-Sundberg, Magnus ; Pääbo, Svante ; Zeberg, Hugo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-28bba706b6c6531ef65ee74eeabf421f0f029c5c8adc0c7f276d9144b2d4a1123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>45/43</topic><topic>692/499</topic><topic>692/700/155</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chromosome 10</topic><topic>Clinical medicine</topic><topic>Cytochrome</topic><topic>Cytochrome P450</topic><topic>Drug dosages</topic><topic>Drug metabolism</topic><topic>Enzymes</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Genomes</topic><topic>Haplotypes</topic><topic>Hominids</topic><topic>Human Genetics</topic><topic>Linkage disequilibrium</topic><topic>Metabolism</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oncology</topic><topic>Pharmacotherapy</topic><topic>Phenytoin</topic><topic>Population</topic><topic>Psychopharmacology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haeggström, Sigrid</creatorcontrib><creatorcontrib>Ingelman-Sundberg, Magnus</creatorcontrib><creatorcontrib>Pääbo, Svante</creatorcontrib><creatorcontrib>Zeberg, Hugo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The pharmacogenomics journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haeggström, Sigrid</au><au>Ingelman-Sundberg, Magnus</au><au>Pääbo, Svante</au><au>Zeberg, Hugo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals</atitle><jtitle>The pharmacogenomics journal</jtitle><stitle>Pharmacogenomics J</stitle><date>2022-07-01</date><risdate>2022</risdate><volume>22</volume><issue>4</issue><spage>247</spage><epage>249</epage><pages>247-249</pages><issn>1470-269X</issn><eissn>1473-1150</eissn><abstract>Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes
CYP2C8
and
CYP2C9
on chromosome 10 exhibits linkage disequilibrium between the
CYP2C8*3
and
CYP2C9*2
alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35780191</pmid><doi>10.1038/s41397-022-00284-6</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-7255-9079</orcidid><orcidid>https://orcid.org/0000-0001-7118-1249</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-269X |
| ispartof | The pharmacogenomics journal, 2022-07, Vol.22 (4), p.247-249 |
| issn | 1470-269X 1473-1150 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9363273 |
| source | Alma/SFX Local Collection |
| subjects | 45/43 692/499 692/700/155 Biomedical and Life Sciences Biomedicine Chromosome 10 Clinical medicine Cytochrome Cytochrome P450 Drug dosages Drug metabolism Enzymes Gene Expression Genes Genetic diversity Genomes Haplotypes Hominids Human Genetics Linkage disequilibrium Metabolism Nonsteroidal anti-inflammatory drugs Oncology Pharmacotherapy Phenytoin Population Psychopharmacology Toxicity |
| title | The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A44%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20clinically%20relevant%20CYP2C83%20and%20CYP2C92%20haplotype%20is%20inherited%20from%20Neandertals&rft.jtitle=The%20pharmacogenomics%20journal&rft.au=Haeggstr%C3%B6m,%20Sigrid&rft.date=2022-07-01&rft.volume=22&rft.issue=4&rft.spage=247&rft.epage=249&rft.pages=247-249&rft.issn=1470-269X&rft.eissn=1473-1150&rft_id=info:doi/10.1038/s41397-022-00284-6&rft_dat=%3Cproquest_pubme%3E2684097544%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2700172283&rft_id=info:pmid/35780191&rfr_iscdi=true |