Effects of Acupuncture on Cortical Activation in Patients with Disorders of Consciousness: A Functional Near-Infrared Spectroscopy Study
Background. Disorder of consciousness (DoC) is a clinical condition caused by severe brain damage. Some studies have reported that acupuncture, a traditional Chinese treatment, could facilitate the recovery of the patient’s consciousness. The therapeutic effects of acupuncture may be due to its modu...
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description | Background. Disorder of consciousness (DoC) is a clinical condition caused by severe brain damage. Some studies have reported that acupuncture, a traditional Chinese treatment, could facilitate the recovery of the patient’s consciousness. The therapeutic effects of acupuncture may be due to its modulation of facilitating cortex (PFC) activity, but it has not been greatly demonstrated. Objectives. We intended to observe the effects of acupuncture on prefrontal cortical activity, explore the potential correlation between cortical activation and the severity of DoC, and analyze the functional brain network connectivity to provide a theoretical basis for its application in clinical practice. Methods. Participants diagnosed with DoC were included in the study. Before the intervention, we assessed the patient’s state of consciousness using relevant scales, such as the Glasgow coma scale (GCS) and the coma recovery scale-revised (CRS-R). All patients received acupuncture manipulation with the functional near-infrared spectroscopy (fNIRS) system monitored. Result. A total of 16 subjects participated in our study. We observed that the concentration of oxygenated hemoglobin (HbO) in the PFC was increased during the acupuncture manipulation and declined during the resting state. Then, the connection strength of the left cerebral cortex was generally higher than that of the right. Finally, we observed only a weak difference in hemodynamic responses of PFC between the vegetative state (VS) and minimally conscious state (MCS) groups. However, the difference was not statistically significant. Conclusion. Our results indicated that acupuncture can increase the concentration of HbO in the PFC and strengthen the connection strength of the left cerebral cortex. However, our present study did not find a significant correlation between the cortical hemodynamic response and the severity of DoC. |
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Disorder of consciousness (DoC) is a clinical condition caused by severe brain damage. Some studies have reported that acupuncture, a traditional Chinese treatment, could facilitate the recovery of the patient’s consciousness. The therapeutic effects of acupuncture may be due to its modulation of facilitating cortex (PFC) activity, but it has not been greatly demonstrated. Objectives. We intended to observe the effects of acupuncture on prefrontal cortical activity, explore the potential correlation between cortical activation and the severity of DoC, and analyze the functional brain network connectivity to provide a theoretical basis for its application in clinical practice. Methods. Participants diagnosed with DoC were included in the study. Before the intervention, we assessed the patient’s state of consciousness using relevant scales, such as the Glasgow coma scale (GCS) and the coma recovery scale-revised (CRS-R). All patients received acupuncture manipulation with the functional near-infrared spectroscopy (fNIRS) system monitored. Result. A total of 16 subjects participated in our study. We observed that the concentration of oxygenated hemoglobin (HbO) in the PFC was increased during the acupuncture manipulation and declined during the resting state. Then, the connection strength of the left cerebral cortex was generally higher than that of the right. Finally, we observed only a weak difference in hemodynamic responses of PFC between the vegetative state (VS) and minimally conscious state (MCS) groups. However, the difference was not statistically significant. Conclusion. Our results indicated that acupuncture can increase the concentration of HbO in the PFC and strengthen the connection strength of the left cerebral cortex. However, our present study did not find a significant correlation between the cortical hemodynamic response and the severity of DoC.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/5711961</identifier><identifier>PMID: 35958938</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Acupuncture ; Brain injury ; Cerebral cortex ; Coma ; Consciousness ; Experiments ; Glasgow Coma Scale ; Hemoglobin ; I.R. radiation ; Infrared spectroscopy ; Neural networks ; Patients ; Spectrum analysis ; Statistical analysis ; Traumatic brain injury ; Unconsciousness</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-07, Vol.2022, p.1-10</ispartof><rights>Copyright © 2022 Xin Wen et al.</rights><rights>Copyright © 2022 Xin Wen et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Wen Xin et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3061-e571d1d06772ae33bcb26b2a4e99e9d30dcf21262612770b4319fc4b4d10b9e03</citedby><cites>FETCH-LOGICAL-c3061-e571d1d06772ae33bcb26b2a4e99e9d30dcf21262612770b4319fc4b4d10b9e03</cites><orcidid>0000-0002-5439-2279 ; 0000-0002-5438-6477 ; 0000-0003-1754-1893 ; 0000-0003-2892-0071 ; 0000-0002-1732-7697 ; 0000-0003-1483-0921 ; 0000-0001-8929-5148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363174/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363174/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Zhang, Zhiqian</contributor><contributor>Zhiqian Zhang</contributor><creatorcontrib>Wen, Xin</creatorcontrib><creatorcontrib>Liu, Zicai</creatorcontrib><creatorcontrib>Shao, Yuchun</creatorcontrib><creatorcontrib>Peng, Yang</creatorcontrib><creatorcontrib>Liu, Huiyu</creatorcontrib><creatorcontrib>Wang, Minghong</creatorcontrib><creatorcontrib>Chen, Junbin</creatorcontrib><title>Effects of Acupuncture on Cortical Activation in Patients with Disorders of Consciousness: A Functional Near-Infrared Spectroscopy Study</title><title>Evidence-based complementary and alternative medicine</title><description>Background. Disorder of consciousness (DoC) is a clinical condition caused by severe brain damage. Some studies have reported that acupuncture, a traditional Chinese treatment, could facilitate the recovery of the patient’s consciousness. The therapeutic effects of acupuncture may be due to its modulation of facilitating cortex (PFC) activity, but it has not been greatly demonstrated. Objectives. We intended to observe the effects of acupuncture on prefrontal cortical activity, explore the potential correlation between cortical activation and the severity of DoC, and analyze the functional brain network connectivity to provide a theoretical basis for its application in clinical practice. Methods. Participants diagnosed with DoC were included in the study. Before the intervention, we assessed the patient’s state of consciousness using relevant scales, such as the Glasgow coma scale (GCS) and the coma recovery scale-revised (CRS-R). All patients received acupuncture manipulation with the functional near-infrared spectroscopy (fNIRS) system monitored. Result. A total of 16 subjects participated in our study. We observed that the concentration of oxygenated hemoglobin (HbO) in the PFC was increased during the acupuncture manipulation and declined during the resting state. Then, the connection strength of the left cerebral cortex was generally higher than that of the right. Finally, we observed only a weak difference in hemodynamic responses of PFC between the vegetative state (VS) and minimally conscious state (MCS) groups. However, the difference was not statistically significant. Conclusion. Our results indicated that acupuncture can increase the concentration of HbO in the PFC and strengthen the connection strength of the left cerebral cortex. However, our present study did not find a significant correlation between the cortical hemodynamic response and the severity of DoC.</description><subject>Acupuncture</subject><subject>Brain injury</subject><subject>Cerebral cortex</subject><subject>Coma</subject><subject>Consciousness</subject><subject>Experiments</subject><subject>Glasgow Coma Scale</subject><subject>Hemoglobin</subject><subject>I.R. radiation</subject><subject>Infrared spectroscopy</subject><subject>Neural networks</subject><subject>Patients</subject><subject>Spectrum analysis</subject><subject>Statistical analysis</subject><subject>Traumatic brain injury</subject><subject>Unconsciousness</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kd9KHDEUxkOxqLXe9QEC3gh2NH9mJhMvhGWrVZC2YAu9C5nkTDcym4zJjLJv0Mdu1l2EeuFVDie_8yXn-xD6RMkppVV1xghjZ5WgVNb0HdqnoqRFyZpm56UWv_fQh5TuCWFSCLGL9nglq0byZh_9vew6MGPCocMzMw2TN-MUAQeP5yGOzug-90f3qEeXe87jH7kCnyee3LjAX1wK0UJ8FpgHn4wLU_KQ0jme4au1XJ7LIt9Ax-LGd1FHsPhuyI_GkEwYVvhunOzqI3rf6T7B4fY8QL-uLn_Or4vb719v5rPbwnBS0wLyppZaUgvBNHDempbVLdMlSAnScmJNxyirWU2ZEKQtOZWdKdvSUtJKIPwAXWx0h6ldgjV5lah7NUS31HGlgnbq_xvvFupPeFSS1zwbmgWOtwIxPEyQRrV0yUDfaw95dcUEYbSpGGsyevQKvQ9TzG48U1RWUjZ1pj5vKJMNSRG6l89QotYRq3XEahtxxk82-MJ5q5_c2_Q_kFemWA</recordid><startdate>20220714</startdate><enddate>20220714</enddate><creator>Wen, Xin</creator><creator>Liu, Zicai</creator><creator>Shao, Yuchun</creator><creator>Peng, Yang</creator><creator>Liu, Huiyu</creator><creator>Wang, Minghong</creator><creator>Chen, Junbin</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5439-2279</orcidid><orcidid>https://orcid.org/0000-0002-5438-6477</orcidid><orcidid>https://orcid.org/0000-0003-1754-1893</orcidid><orcidid>https://orcid.org/0000-0003-2892-0071</orcidid><orcidid>https://orcid.org/0000-0002-1732-7697</orcidid><orcidid>https://orcid.org/0000-0003-1483-0921</orcidid><orcidid>https://orcid.org/0000-0001-8929-5148</orcidid></search><sort><creationdate>20220714</creationdate><title>Effects of Acupuncture on Cortical Activation in Patients with Disorders of Consciousness: A Functional Near-Infrared Spectroscopy Study</title><author>Wen, Xin ; 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Disorder of consciousness (DoC) is a clinical condition caused by severe brain damage. Some studies have reported that acupuncture, a traditional Chinese treatment, could facilitate the recovery of the patient’s consciousness. The therapeutic effects of acupuncture may be due to its modulation of facilitating cortex (PFC) activity, but it has not been greatly demonstrated. Objectives. We intended to observe the effects of acupuncture on prefrontal cortical activity, explore the potential correlation between cortical activation and the severity of DoC, and analyze the functional brain network connectivity to provide a theoretical basis for its application in clinical practice. Methods. Participants diagnosed with DoC were included in the study. Before the intervention, we assessed the patient’s state of consciousness using relevant scales, such as the Glasgow coma scale (GCS) and the coma recovery scale-revised (CRS-R). All patients received acupuncture manipulation with the functional near-infrared spectroscopy (fNIRS) system monitored. Result. A total of 16 subjects participated in our study. We observed that the concentration of oxygenated hemoglobin (HbO) in the PFC was increased during the acupuncture manipulation and declined during the resting state. Then, the connection strength of the left cerebral cortex was generally higher than that of the right. Finally, we observed only a weak difference in hemodynamic responses of PFC between the vegetative state (VS) and minimally conscious state (MCS) groups. However, the difference was not statistically significant. Conclusion. Our results indicated that acupuncture can increase the concentration of HbO in the PFC and strengthen the connection strength of the left cerebral cortex. However, our present study did not find a significant correlation between the cortical hemodynamic response and the severity of DoC.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>35958938</pmid><doi>10.1155/2022/5711961</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5439-2279</orcidid><orcidid>https://orcid.org/0000-0002-5438-6477</orcidid><orcidid>https://orcid.org/0000-0003-1754-1893</orcidid><orcidid>https://orcid.org/0000-0003-2892-0071</orcidid><orcidid>https://orcid.org/0000-0002-1732-7697</orcidid><orcidid>https://orcid.org/0000-0003-1483-0921</orcidid><orcidid>https://orcid.org/0000-0001-8929-5148</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acupuncture Brain injury Cerebral cortex Coma Consciousness Experiments Glasgow Coma Scale Hemoglobin I.R. radiation Infrared spectroscopy Neural networks Patients Spectrum analysis Statistical analysis Traumatic brain injury Unconsciousness |
title | Effects of Acupuncture on Cortical Activation in Patients with Disorders of Consciousness: A Functional Near-Infrared Spectroscopy Study |
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