HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis
Objectives : To date, there is still a significant debate on the role of human papilloma virus (HPV) infection in transformation of inverted papillomas (IPs) to squamous cell carcinoma (SCC). This study was designed to determine if the presence of HPV in a sinonasal IP increases the risk of malignan...
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| Veröffentlicht in: | International forum of allergy & rhinology 2021-10, Vol.11 (10), p.1461-1471 |
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| creator | Stepp, Wesley H. Farzal, Zainab Kimple, Adam J. Ebert, Charles S. Senior, Brent A. Zanation, Adam M. Thorp, Brian D. |
| description | Objectives
: To date, there is still a significant debate on the role of human papilloma virus (HPV) infection in transformation of inverted papillomas (IPs) to squamous cell carcinoma (SCC). This study was designed to determine if the presence of HPV in a sinonasal IP increases the risk of malignant transformation to IPSCC.
Methods
: Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, 19 high‐quality case‐control and cohort studies with tissue‐diagnosed IP or IPSCC and HPV diagnosis were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the Mantel–Haenszel method with correction for random effects. Subgroup, publication bias and a sensitivity analyses were also performed.
Results
: Nineteen studies with minimal bias met the inclusion criteria for quality and identified HPV infection in an IP. The pooled data revealed a strong association with progression to malignancy with an unweighted, pooled OR of 2.38 (CI95 1.47 to 3.83) and a weighted OR of 2.80 (CI95 1.42 to 5.51). Sensitivity analysis revealed that no single study contributed significantly to our pooled OR calculations (ORs 2.52 to 3.57). Subgroup analyses stratified by publication date, nucleic acid target, HPV detection method and type, sample size, and region all demonstrated a positive association of HPV with IPSCC.
Conclusions
: There appears to be a significant association between HPV infection and malignant transformation of IPs. While HPV testing is not currently the standard of care for IPs, these data suggest a link between the two and suggest further studies should be performed to identify a link between the virus and malignant transformation. |
| doi_str_mv | 10.1002/alr.22810 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9363156</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2522623891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5090-fb1a33bb726118613310d93b1cfb653a1ae69d435e9ee6f29b40cf75210d2e733</originalsourceid><addsrcrecordid>eNp10d1KHDEUB_AgLSrWi76ABHpTL1bzMclMvCgsYlVYaCn9uAxnZs9oJJOsyayyd32EPmOfxOjq0haamwTy4885_Al5y9kRZ0wcg09HQjScbZFdwSox0aapXm3etd4h-znfsHIUV4rX22RHSqN0xcQu-XHx-Tt1gY7XSAfw7ipAGOmYIOQ-pgFGFwONPc0uxAAZfMF3mEac0wUsnPdxgHxCp3TAEX7__AUB_Cq7_Ia87sFn3H--98i3j2dfTy8ms0_nl6fT2aRTzLBJ33KQsm1roTlvNJeSs7mRLe_6VisJHFCbeSUVGkTdC9NWrOtrJQoTWEu5Rz6scxfLdsB5h6HM7u0iuQHSykZw9u-f4K7tVbyzRmrJlS4B758DUrxdYh7t4HKH3kPAuMxWKCG0kI3hhb77h97EZSoLP6qmLhuoqirqcK26FHNO2G-G4cw-NmZLY_apsWIP_px-I1_6KeB4De6dx9X_k-x09mUd-QCtGqDH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2587611544</pqid></control><display><type>article</type><title>HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Stepp, Wesley H. ; Farzal, Zainab ; Kimple, Adam J. ; Ebert, Charles S. ; Senior, Brent A. ; Zanation, Adam M. ; Thorp, Brian D.</creator><creatorcontrib>Stepp, Wesley H. ; Farzal, Zainab ; Kimple, Adam J. ; Ebert, Charles S. ; Senior, Brent A. ; Zanation, Adam M. ; Thorp, Brian D.</creatorcontrib><description>Objectives
: To date, there is still a significant debate on the role of human papilloma virus (HPV) infection in transformation of inverted papillomas (IPs) to squamous cell carcinoma (SCC). This study was designed to determine if the presence of HPV in a sinonasal IP increases the risk of malignant transformation to IPSCC.
Methods
: Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, 19 high‐quality case‐control and cohort studies with tissue‐diagnosed IP or IPSCC and HPV diagnosis were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the Mantel–Haenszel method with correction for random effects. Subgroup, publication bias and a sensitivity analyses were also performed.
Results
: Nineteen studies with minimal bias met the inclusion criteria for quality and identified HPV infection in an IP. The pooled data revealed a strong association with progression to malignancy with an unweighted, pooled OR of 2.38 (CI95 1.47 to 3.83) and a weighted OR of 2.80 (CI95 1.42 to 5.51). Sensitivity analysis revealed that no single study contributed significantly to our pooled OR calculations (ORs 2.52 to 3.57). Subgroup analyses stratified by publication date, nucleic acid target, HPV detection method and type, sample size, and region all demonstrated a positive association of HPV with IPSCC.
Conclusions
: There appears to be a significant association between HPV infection and malignant transformation of IPs. While HPV testing is not currently the standard of care for IPs, these data suggest a link between the two and suggest further studies should be performed to identify a link between the virus and malignant transformation.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.22810</identifier><identifier>PMID: 33956402</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Carcinoma, Squamous Cell ; Head & neck cancer ; head and neck cancer ; HPV ; human papilloma virus ; Human papillomavirus ; Humans ; Infections ; inverted papilloma ; Malignancy ; Meta-analysis ; Nose Neoplasms ; Papilloma, Inverted ; Papillomavirus Infections - epidemiology ; Paranasal Sinus Neoplasms - epidemiology ; Sensitivity analysis ; sinonasal tumors ; skull base cancer ; Squamous cell carcinoma</subject><ispartof>International forum of allergy & rhinology, 2021-10, Vol.11 (10), p.1461-1471</ispartof><rights>2021 ARS‐AAOA, LLC</rights><rights>2021 ARS-AAOA, LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5090-fb1a33bb726118613310d93b1cfb653a1ae69d435e9ee6f29b40cf75210d2e733</citedby><cites>FETCH-LOGICAL-c5090-fb1a33bb726118613310d93b1cfb653a1ae69d435e9ee6f29b40cf75210d2e733</cites><orcidid>0000-0003-2213-1872 ; 0000-0003-1670-8401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.22810$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.22810$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33956402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stepp, Wesley H.</creatorcontrib><creatorcontrib>Farzal, Zainab</creatorcontrib><creatorcontrib>Kimple, Adam J.</creatorcontrib><creatorcontrib>Ebert, Charles S.</creatorcontrib><creatorcontrib>Senior, Brent A.</creatorcontrib><creatorcontrib>Zanation, Adam M.</creatorcontrib><creatorcontrib>Thorp, Brian D.</creatorcontrib><title>HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Objectives
: To date, there is still a significant debate on the role of human papilloma virus (HPV) infection in transformation of inverted papillomas (IPs) to squamous cell carcinoma (SCC). This study was designed to determine if the presence of HPV in a sinonasal IP increases the risk of malignant transformation to IPSCC.
Methods
: Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, 19 high‐quality case‐control and cohort studies with tissue‐diagnosed IP or IPSCC and HPV diagnosis were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the Mantel–Haenszel method with correction for random effects. Subgroup, publication bias and a sensitivity analyses were also performed.
Results
: Nineteen studies with minimal bias met the inclusion criteria for quality and identified HPV infection in an IP. The pooled data revealed a strong association with progression to malignancy with an unweighted, pooled OR of 2.38 (CI95 1.47 to 3.83) and a weighted OR of 2.80 (CI95 1.42 to 5.51). Sensitivity analysis revealed that no single study contributed significantly to our pooled OR calculations (ORs 2.52 to 3.57). Subgroup analyses stratified by publication date, nucleic acid target, HPV detection method and type, sample size, and region all demonstrated a positive association of HPV with IPSCC.
Conclusions
: There appears to be a significant association between HPV infection and malignant transformation of IPs. While HPV testing is not currently the standard of care for IPs, these data suggest a link between the two and suggest further studies should be performed to identify a link between the virus and malignant transformation.</description><subject>Carcinoma, Squamous Cell</subject><subject>Head & neck cancer</subject><subject>head and neck cancer</subject><subject>HPV</subject><subject>human papilloma virus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>inverted papilloma</subject><subject>Malignancy</subject><subject>Meta-analysis</subject><subject>Nose Neoplasms</subject><subject>Papilloma, Inverted</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Paranasal Sinus Neoplasms - epidemiology</subject><subject>Sensitivity analysis</subject><subject>sinonasal tumors</subject><subject>skull base cancer</subject><subject>Squamous cell carcinoma</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10d1KHDEUB_AgLSrWi76ABHpTL1bzMclMvCgsYlVYaCn9uAxnZs9oJJOsyayyd32EPmOfxOjq0haamwTy4885_Al5y9kRZ0wcg09HQjScbZFdwSox0aapXm3etd4h-znfsHIUV4rX22RHSqN0xcQu-XHx-Tt1gY7XSAfw7ipAGOmYIOQ-pgFGFwONPc0uxAAZfMF3mEac0wUsnPdxgHxCp3TAEX7__AUB_Cq7_Ia87sFn3H--98i3j2dfTy8ms0_nl6fT2aRTzLBJ33KQsm1roTlvNJeSs7mRLe_6VisJHFCbeSUVGkTdC9NWrOtrJQoTWEu5Rz6scxfLdsB5h6HM7u0iuQHSykZw9u-f4K7tVbyzRmrJlS4B758DUrxdYh7t4HKH3kPAuMxWKCG0kI3hhb77h97EZSoLP6qmLhuoqirqcK26FHNO2G-G4cw-NmZLY_apsWIP_px-I1_6KeB4De6dx9X_k-x09mUd-QCtGqDH</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Stepp, Wesley H.</creator><creator>Farzal, Zainab</creator><creator>Kimple, Adam J.</creator><creator>Ebert, Charles S.</creator><creator>Senior, Brent A.</creator><creator>Zanation, Adam M.</creator><creator>Thorp, Brian D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2213-1872</orcidid><orcidid>https://orcid.org/0000-0003-1670-8401</orcidid></search><sort><creationdate>202110</creationdate><title>HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis</title><author>Stepp, Wesley H. ; Farzal, Zainab ; Kimple, Adam J. ; Ebert, Charles S. ; Senior, Brent A. ; Zanation, Adam M. ; Thorp, Brian D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5090-fb1a33bb726118613310d93b1cfb653a1ae69d435e9ee6f29b40cf75210d2e733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carcinoma, Squamous Cell</topic><topic>Head & neck cancer</topic><topic>head and neck cancer</topic><topic>HPV</topic><topic>human papilloma virus</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Infections</topic><topic>inverted papilloma</topic><topic>Malignancy</topic><topic>Meta-analysis</topic><topic>Nose Neoplasms</topic><topic>Papilloma, Inverted</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Paranasal Sinus Neoplasms - epidemiology</topic><topic>Sensitivity analysis</topic><topic>sinonasal tumors</topic><topic>skull base cancer</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stepp, Wesley H.</creatorcontrib><creatorcontrib>Farzal, Zainab</creatorcontrib><creatorcontrib>Kimple, Adam J.</creatorcontrib><creatorcontrib>Ebert, Charles S.</creatorcontrib><creatorcontrib>Senior, Brent A.</creatorcontrib><creatorcontrib>Zanation, Adam M.</creatorcontrib><creatorcontrib>Thorp, Brian D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stepp, Wesley H.</au><au>Farzal, Zainab</au><au>Kimple, Adam J.</au><au>Ebert, Charles S.</au><au>Senior, Brent A.</au><au>Zanation, Adam M.</au><au>Thorp, Brian D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>11</volume><issue>10</issue><spage>1461</spage><epage>1471</epage><pages>1461-1471</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Objectives
: To date, there is still a significant debate on the role of human papilloma virus (HPV) infection in transformation of inverted papillomas (IPs) to squamous cell carcinoma (SCC). This study was designed to determine if the presence of HPV in a sinonasal IP increases the risk of malignant transformation to IPSCC.
Methods
: Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, 19 high‐quality case‐control and cohort studies with tissue‐diagnosed IP or IPSCC and HPV diagnosis were analyzed. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the Mantel–Haenszel method with correction for random effects. Subgroup, publication bias and a sensitivity analyses were also performed.
Results
: Nineteen studies with minimal bias met the inclusion criteria for quality and identified HPV infection in an IP. The pooled data revealed a strong association with progression to malignancy with an unweighted, pooled OR of 2.38 (CI95 1.47 to 3.83) and a weighted OR of 2.80 (CI95 1.42 to 5.51). Sensitivity analysis revealed that no single study contributed significantly to our pooled OR calculations (ORs 2.52 to 3.57). Subgroup analyses stratified by publication date, nucleic acid target, HPV detection method and type, sample size, and region all demonstrated a positive association of HPV with IPSCC.
Conclusions
: There appears to be a significant association between HPV infection and malignant transformation of IPs. While HPV testing is not currently the standard of care for IPs, these data suggest a link between the two and suggest further studies should be performed to identify a link between the virus and malignant transformation.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33956402</pmid><doi>10.1002/alr.22810</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2213-1872</orcidid><orcidid>https://orcid.org/0000-0003-1670-8401</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International forum of allergy & rhinology, 2021-10, Vol.11 (10), p.1461-1471 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Carcinoma, Squamous Cell Head & neck cancer head and neck cancer HPV human papilloma virus Human papillomavirus Humans Infections inverted papilloma Malignancy Meta-analysis Nose Neoplasms Papilloma, Inverted Papillomavirus Infections - epidemiology Paranasal Sinus Neoplasms - epidemiology Sensitivity analysis sinonasal tumors skull base cancer Squamous cell carcinoma |
| title | HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis |
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