Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus)
There is substantial evidence linking the prefrontal cortex (PFC) to a variety of cognitive abilities, with adolescence being a critical period in its development. In the current study, we investigated the neural basis of differences in learning in pre-adolescent common marmosets. At 8 months old, m...
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| Veröffentlicht in: | Behavioural brain research 2022-07, Vol.430, p.113920-113920, Article 113920 |
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| container_title | Behavioural brain research |
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| creator | Ash, Hayley Chang, Arnold Ortiz, Richard J. Kulkarni, Praveen Rauch, Beth Colman, Ricki Ferris, Craig F. Ziegler, Toni E. |
| description | There is substantial evidence linking the prefrontal cortex (PFC) to a variety of cognitive abilities, with adolescence being a critical period in its development. In the current study, we investigated the neural basis of differences in learning in pre-adolescent common marmosets. At 8 months old, marmosets were given anatomical and resting state MRI scans (n = 24). At 9 months old, association learning and inhibitory control was tested using a ‘go/no go’ visual discrimination (VD) task. Marmosets were grouped into ‘learners’ (n = 12) and “non-learners” (n = 12), and associations between cognitive performance and sub-regional PFC volumes, as well as PFC connectivity patterns, were investigated. “Learners” had significantly (p |
| doi_str_mv | 10.1016/j.bbr.2022.113920 |
| format | Article |
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•We investigated the neural basis of learning differences in pre-adolescent marmosets.•A visual discrimination task and brain imaging sessions were conducted.•Learning was associated with larger volumes of 4 prefrontal cortex sub-regions.•Learners also had more refined prefrontal cortex connectivity patterns.•Greater prefrontal development may aid cognitive control in young marmosets.</description><identifier>ISSN: 0166-4328</identifier><identifier>ISSN: 1872-7549</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2022.113920</identifier><identifier>PMID: 35595058</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Brain ; Brain volume ; Callithrix ; Development ; Learning ; Magnetic Resonance Imaging ; Marmoset ; Neural Pathways - physiology ; Prefrontal cortex ; Prefrontal Cortex - diagnostic imaging ; Resting state functional connectivity</subject><ispartof>Behavioural brain research, 2022-07, Vol.430, p.113920-113920, Article 113920</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-6b6b27b922eac5fd0422bf9b55f9ba6d1b76c1b59a39658f9406d319de76ba373</citedby><cites>FETCH-LOGICAL-c451t-6b6b27b922eac5fd0422bf9b55f9ba6d1b76c1b59a39658f9406d319de76ba373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2022.113920$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35595058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ash, Hayley</creatorcontrib><creatorcontrib>Chang, Arnold</creatorcontrib><creatorcontrib>Ortiz, Richard J.</creatorcontrib><creatorcontrib>Kulkarni, Praveen</creatorcontrib><creatorcontrib>Rauch, Beth</creatorcontrib><creatorcontrib>Colman, Ricki</creatorcontrib><creatorcontrib>Ferris, Craig F.</creatorcontrib><creatorcontrib>Ziegler, Toni E.</creatorcontrib><title>Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus)</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>There is substantial evidence linking the prefrontal cortex (PFC) to a variety of cognitive abilities, with adolescence being a critical period in its development. In the current study, we investigated the neural basis of differences in learning in pre-adolescent common marmosets. At 8 months old, marmosets were given anatomical and resting state MRI scans (n = 24). At 9 months old, association learning and inhibitory control was tested using a ‘go/no go’ visual discrimination (VD) task. Marmosets were grouped into ‘learners’ (n = 12) and “non-learners” (n = 12), and associations between cognitive performance and sub-regional PFC volumes, as well as PFC connectivity patterns, were investigated. “Learners” had significantly (p < 0.05) larger volumes of areas 11, 25, 47 and 32 than ‘non-learners’, although ‘non-learners’ had significantly larger volumes of areas 24a and 8 v than “learners”. There was also a significant correlation between average % correct responses to the ‘punished’ stimulus and volume of area 47. Further, ‘non-learners’ had significantly greater global PFC connections, as well as significantly greater numbers of connections between the PFC and basal ganglia, cerebellum and hippocampus, compared to ‘learners’. These results suggest that larger sub-regions of the orbitofrontal cortex and ventromedial PFC, as well more refined PFC connectivity patterns to other brain regions associated with learning, may be important in successful response inhibition. This study therefore offers new information on the neurodevelopment of individual differences in cognition during pre-adolescence in non-human primates.
•We investigated the neural basis of learning differences in pre-adolescent marmosets.•A visual discrimination task and brain imaging sessions were conducted.•Learning was associated with larger volumes of 4 prefrontal cortex sub-regions.•Learners also had more refined prefrontal cortex connectivity patterns.•Greater prefrontal development may aid cognitive control in young marmosets.</description><subject>Animals</subject><subject>Brain</subject><subject>Brain volume</subject><subject>Callithrix</subject><subject>Development</subject><subject>Learning</subject><subject>Magnetic Resonance Imaging</subject><subject>Marmoset</subject><subject>Neural Pathways - physiology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Resting state functional connectivity</subject><issn>0166-4328</issn><issn>1872-7549</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UUuLFDEYDKK44-oP8CI5rocek3Qn3UEQZPAFCx7Uc8jj650M3cmYpMf1b_iLTTProhcvefBVVSpVCD2nZEsJFa8OW2PSlhHGtpS2kpEHaEOHnjU97-RDtKkY0XQtGy7Qk5wPhJCOcPoYXbScS074sEG_vpS02LIkPWEdHB6XYIuPoV5POnm9njP2AZc94GOCMcVQ6tDGVOAW6wRY5xxtRYLDP3zZ4wl0Cj7crKzKaLSLE2QLoVTWPMeAZ53mmKFkfLXT01RJyd_ig7Z2v-SXT9GjUU8Znt3tl-jb-3dfdx-b688fPu3eXje247Q0wgjDeiMZA2356EjHmBml4bwuWjhqemGp4VK3UvBhlB0RrqXSQS-Mbvv2Er056x4XM4NbDdYU1DH56u-nitqrfyfB79VNPCnZCiZlVwWu7gRS_L5ALmr29Z_TpAPEJSsmRN8PopekQukZalPMucZ4_wwlau1SHVTtUq1dqnOXlfPib3_3jD_lVcDrMwBqSicPSWXrIVhwPoEtykX_H_nfrly0WQ</recordid><startdate>20220726</startdate><enddate>20220726</enddate><creator>Ash, Hayley</creator><creator>Chang, Arnold</creator><creator>Ortiz, Richard J.</creator><creator>Kulkarni, Praveen</creator><creator>Rauch, Beth</creator><creator>Colman, Ricki</creator><creator>Ferris, Craig F.</creator><creator>Ziegler, Toni E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220726</creationdate><title>Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus)</title><author>Ash, Hayley ; Chang, Arnold ; Ortiz, Richard J. ; Kulkarni, Praveen ; Rauch, Beth ; Colman, Ricki ; Ferris, Craig F. ; Ziegler, Toni E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-6b6b27b922eac5fd0422bf9b55f9ba6d1b76c1b59a39658f9406d319de76ba373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Brain</topic><topic>Brain volume</topic><topic>Callithrix</topic><topic>Development</topic><topic>Learning</topic><topic>Magnetic Resonance Imaging</topic><topic>Marmoset</topic><topic>Neural Pathways - physiology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Resting state functional connectivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ash, Hayley</creatorcontrib><creatorcontrib>Chang, Arnold</creatorcontrib><creatorcontrib>Ortiz, Richard J.</creatorcontrib><creatorcontrib>Kulkarni, Praveen</creatorcontrib><creatorcontrib>Rauch, Beth</creatorcontrib><creatorcontrib>Colman, Ricki</creatorcontrib><creatorcontrib>Ferris, Craig F.</creatorcontrib><creatorcontrib>Ziegler, Toni E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ash, Hayley</au><au>Chang, Arnold</au><au>Ortiz, Richard J.</au><au>Kulkarni, Praveen</au><au>Rauch, Beth</au><au>Colman, Ricki</au><au>Ferris, Craig F.</au><au>Ziegler, Toni E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus)</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2022-07-26</date><risdate>2022</risdate><volume>430</volume><spage>113920</spage><epage>113920</epage><pages>113920-113920</pages><artnum>113920</artnum><issn>0166-4328</issn><issn>1872-7549</issn><eissn>1872-7549</eissn><abstract>There is substantial evidence linking the prefrontal cortex (PFC) to a variety of cognitive abilities, with adolescence being a critical period in its development. In the current study, we investigated the neural basis of differences in learning in pre-adolescent common marmosets. At 8 months old, marmosets were given anatomical and resting state MRI scans (n = 24). At 9 months old, association learning and inhibitory control was tested using a ‘go/no go’ visual discrimination (VD) task. Marmosets were grouped into ‘learners’ (n = 12) and “non-learners” (n = 12), and associations between cognitive performance and sub-regional PFC volumes, as well as PFC connectivity patterns, were investigated. “Learners” had significantly (p < 0.05) larger volumes of areas 11, 25, 47 and 32 than ‘non-learners’, although ‘non-learners’ had significantly larger volumes of areas 24a and 8 v than “learners”. There was also a significant correlation between average % correct responses to the ‘punished’ stimulus and volume of area 47. Further, ‘non-learners’ had significantly greater global PFC connections, as well as significantly greater numbers of connections between the PFC and basal ganglia, cerebellum and hippocampus, compared to ‘learners’. These results suggest that larger sub-regions of the orbitofrontal cortex and ventromedial PFC, as well more refined PFC connectivity patterns to other brain regions associated with learning, may be important in successful response inhibition. This study therefore offers new information on the neurodevelopment of individual differences in cognition during pre-adolescence in non-human primates.
•We investigated the neural basis of learning differences in pre-adolescent marmosets.•A visual discrimination task and brain imaging sessions were conducted.•Learning was associated with larger volumes of 4 prefrontal cortex sub-regions.•Learners also had more refined prefrontal cortex connectivity patterns.•Greater prefrontal development may aid cognitive control in young marmosets.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35595058</pmid><doi>10.1016/j.bbr.2022.113920</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain Brain volume Callithrix Development Learning Magnetic Resonance Imaging Marmoset Neural Pathways - physiology Prefrontal cortex Prefrontal Cortex - diagnostic imaging Resting state functional connectivity |
| title | Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus) |
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