An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

Objective:Efforts to prevent depression, the leading cause of disability worldwide, have focused on a limited number of candidate factors. Using phenotypic and genomic data from over 100,000 UK Biobank participants, the authors sought to systematically screen and validate a wide range of potential m...

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Veröffentlicht in:	The American journal of psychiatry 2020-10, Vol.177 (10), p.944-954
Hauptverfasser:	Choi, Karmel W, Stein, Murray B, Nishimi, Kristen M, Ge, Tian, Coleman, Jonathan R.I, Chen, Chia-Yen, Ratanatharathorn, Andrew, Zheutlin, Amanda B, Dunn, Erin C, Breen, Gerome, Koenen, Karestan C, Smoller, Jordan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety Clinical significance Databases as Topic Depression - etiology Depression - genetics Depression - prevention & control Diet Exercise - psychology Female Humans Male Mendelian Randomization Analysis Mental depression Multifactorial Inheritance - genetics Risk Factors Screen Time Sleep Sleep Hygiene Social networks
Online-Zugang:	Volltext
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