High Expression of Programmed Death Ligand 1 and Programmed Death Ligand 2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors

To evaluate the expression of programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) in ocular adnexal sebaceous carcinoma (OASC), and to appraise these findings within the context of recent comparable studies. Retrospective case series. Twenty cases of primary OASC were immunostain...

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Veröffentlicht in:	American journal of ophthalmology 2020-12, Vol.220, p.128-139
Hauptverfasser:	Wolkow, Natalie, Jakobiec, Frederick A., Afrogheh, Amir H., Pai, Sara I., Faquin, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Sebaceous - genetics Adenocarcinoma, Sebaceous - metabolism Adenocarcinoma, Sebaceous - pathology Adolescent Adult Aged Aged, 80 and over Apoptosis B7-H1 Antigen - biosynthesis B7-H1 Antigen - genetics Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biopsy Child Child, Preschool Drugs Eye Neoplasms - genetics Eye Neoplasms - metabolism Eye Neoplasms - pathology Female Gene Expression Regulation, Neoplastic Hospitals Humans Ligands Lymphatic system Male Medical records Metastasis Middle Aged Monoclonal antibodies Patients Programmed Cell Death 1 Ligand 2 Protein - biosynthesis Programmed Cell Death 1 Ligand 2 Protein - genetics Retrospective Studies RNA, Neoplasm - genetics Sebaceous Gland Neoplasms - diagnosis Sebaceous Gland Neoplasms - genetics Sebaceous Gland Neoplasms - metabolism Surgery Tumors Young Adult
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