An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen

Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic. Here the development is reported of a vaccine based on the SARS-CoV-2 receptor-binding domain (RBD), produced in the yeast Pichia...

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Veröffentlicht in:	New biotechnology 2022-12, Vol.72, p.11-21
Hauptverfasser:	Limonta-Fernández, Miladys, Chinea-Santiago, Glay, Martín-Dunn, Alejandro Miguel, Gonzalez-Roche, Diamile, Bequet-Romero, Monica, Marquez-Perera, Gabriel, González-Moya, Isabel, Canaan-Haden-Ayala, Camila, Cabrales-Rico, Ania, Espinosa-Rodríguez, Luis Ariel, Ramos-Gómez, Yassel, Andujar-Martínez, Ivan, González-López, Luis Javier, de la Iglesia, Mariela Perez, Zamora-Sanchez, Jesus, Cruz-Sui, Otto, Lemos-Pérez, Gilda, Cabrera-Herrera, Gleysin, Valdes-Hernández, Jorge, Martinez-Diaz, Eduardo, Pimentel-Vazquez, Eulogio, Ayala-Avila, Marta, Guillén-Nieto, Gerardo
Format:	Artikel
Sprache:	eng
Schlagworte:	alum amino acids Animals antigens biotechnology circular dichroism spectroscopy COVID-19 COVID-19 - prevention & control COVID-19 infection COVID-19 Vaccines culture media fermentation fermenters HEK293 Cells Humans immunization interleukin-2 interleukin-4 interleukin-6 Komagataella pastoris lungs mass spectrometry methanol Mice neutralization P. pastoris Pandemics - prevention & control peptidyl-dipeptidase A Primates purification methods RBD recombinant proteins SARS-CoV-2 secretion Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus splenocytes Subunit vaccine vaccines yeasts
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