In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy of the bile ducts within the liver characterized by high levels of genetic heterogeneity. In the context of such genetic variability, determining which oncogenic mutations drive ICC growth has been difficult, and developing modes of p...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-04, Vol.82 (8), p.1548-1559
Hauptverfasser:	Younger, Nicholas T, Wilson, Mollie L, Martinez Lyons, Anabel, Jarman, Edward J, Meynert, Alison M, Grimes, Graeme R, Gournopanos, Konstantinos, Waddell, Scott H, Tennant, Peter A, Wilson, David H, Guest, Rachel V, Wigmore, Stephen J, Acosta, Juan Carlos, Kendall, Timothy J, Taylor, Martin S, Sproul, Duncan, Mill, Pleasantine, Boulter, Luke
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Genetic Heterogeneity Humans Molecular Cell Biology Phosphatidylinositol 3-Kinases - genetics
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